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Tropical"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1465-9921-8-42","article-title":"AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid","volume":"8","author":"KC Jambo","year":"2007","journal-title":"Respiratory research"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2249.1995.tb03656.x","article-title":"The level of the serum opsonin, mannan-binding protein in HIV-1 antibody-positive patients","volume":"100","author":"SL Nielsen","year":"1995","journal-title":"Clinical and experimental immunology"},{"issue":"6","key":"ref83","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1744-313X.2010.00946.x","article-title":"A clinical case-control study on the association between mannose-binding lectin and susceptibility to HIV-1 infection among northern Han Chinese population","volume":"37","author":"A Sheng","year":"2010","journal-title":"International journal of immunogenetics"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.molimm.2009.08.020","article-title":"Association between mannose-binding lectin and HIV infection and progression in a Chinese population","volume":"47","author":"Y Tan","year":"2009","journal-title":"Molecular immunology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1203\/00006450-199904010-00002","article-title":"Mannose-binding protein B allele confers protection against tuberculous meningitis","volume":"45","author":"EG Hoal-Van Helden","year":"1999","journal-title":"Pediatric research"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/infdis\/162.6.1227","article-title":"Activation of the complement system in human immunodeficiency virus infection: relevance of the classical pathway to pathogenesis and disease severity","volume":"62","author":"G Senaldi","year":"1990","journal-title":"The Journal of infectious diseases"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/00002030-199310000-00002","article-title":"Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins","volume":"7","author":"JS Haurum","year":"1993","journal-title":"AIDS"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1042\/bst0181145","article-title":"Interaction of C1q, and other proteins containing collagen-like domains, with the C1q receptor","volume":"18","author":"R Malhotra","year":"1990","journal-title":"Biochemical Society transactions"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1084\/jem.169.1.185","article-title":"A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus","volume":"169","author":"RA Ezekowitz","year":"1989","journal-title":"The Journal of experimental medicine"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.molimm.2006.01.008","article-title":"Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population","volume":"43","author":"MI Garcia-Laorden","year":"2006","journal-title":"Molecular immunology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/aid.1998.14.695","article-title":"Contribution of the CCR5 and MBL genes to susceptibility to HIV type 1 infection in the Finnish population","volume":"14","author":"T Pastinen","year":"1998","journal-title":"AIDS research and human retroviruses"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1086\/588712","article-title":"Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations","volume":"198","author":"G Catano","year":"2008","journal-title":"The Journal of infectious diseases"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1590\/S0074-02762008000700003","article-title":"Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects","volume":"103","author":"AC Vallinoto","year":"2008","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/QAD.0b013e328342fef1","article-title":"The role of mannose-binding lectin gene polymorphisms in susceptibility to HIV-1 infection in Southern Brazilian patients","volume":"25","author":"GK da Silva","year":"2011","journal-title":"AIDS"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/sj.gene.6363685","article-title":"Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression","volume":"1","author":"M Boniotto","year":"2000","journal-title":"Genes and immunity"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2217\/17460794.3.3.225","article-title":"Mannose-binding lectin in HIV infection","volume":"3","author":"S Eisen","year":"2008","journal-title":"Future virology"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0165-2478(97)00084-9","article-title":"Mannan-binding lectin serum concentrations in HIV-infected patients are influenced by the stage of disease","volume":"58","author":"Z Prohaszka","year":"1997","journal-title":"Immunology letters"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00126334-200304010-00002","article-title":"Mannose-binding lectin in HIV infection: relation to disease progression and highly active antiretroviral therapy","volume":"32","author":"L Heggelund","year":"2003","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1097\/00002030-199817000-00008","article-title":"Presence of the variant mannose-binding lectin alleles associated with slower progression to AIDS. Amsterdam Cohort Study","volume":"12","author":"J Maas","year":"1998","journal-title":"AIDS"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1086\/590498","article-title":"Detrimental effects of mannose-binding lectin (MBL2) promoter genotype XA\/XA on HIV-1 vertical transmission and AIDS progression","volume":"198","author":"A Mangano","year":"2008","journal-title":"The Journal of infectious diseases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T03:54:26Z","timestamp":1691553266000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122659"}},"subtitle":[],"editor":[{"given":"Cordula M.","family":"Stover","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,1]]},"references-count":100,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122659","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,1]]}}}