{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:16:16Z","timestamp":1790302576024,"version":"4.1.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0122662","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T20:22:57Z","timestamp":1427228577000},"page":"e0122662","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Molecular Characterization of Melanoma Cases in Denmark Suspected of Genetic Predisposition"],"prefix":"10.1371","volume":"10","author":[{"given":"Karin A. W.","family":"Wadt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G.","family":"Aoude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Krogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Sunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bojesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Gr\u00f8nskov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nine","family":"Wartacz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Tolstrup-Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Klarskov-Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Borg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Heegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens F.","family":"Kiilgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V. O.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerenaftali","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"J\u00f6nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof T.","family":"Drzewiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Dun\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K.","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"ref1","unstructured":"Danish Cancerregistry. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ssi.dk\/Sundhedsdataogit\/Registre\/Cancerregisteret.aspx\" xlink:type=\"simple\">http:\/\/www.ssi.dk\/Sundhedsdataogit\/Registre\/Cancerregisteret.aspx<\/ext-link>. Accessed 15 October 2014."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1038\/jid.2009.48","article-title":"A population-based study of Australian twins with melanoma suggests a strong genetic contribution to liability","volume":"129","author":"SN Shekar","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.ejca.2013.12.023","article-title":"Familial melanoma by histology and age: joint data from five Nordic countries","volume":"50","author":"M Fallah","year":"2014","journal-title":"Eur J Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejca.2004.10.015","article-title":"Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi","volume":"41","author":"S Gandini","year":"2005","journal-title":"Eur J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejca.2004.10.016","article-title":"Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure","volume":"41","author":"S Gandini","year":"2005","journal-title":"Eur J Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.ejca.2005.03.034","article-title":"Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors","volume":"41","author":"S Gandini","year":"2005","journal-title":"Eur J Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1158\/1055-9965.EPI-09-1249","article-title":"Indoor tanning and risk of melanoma: a case-control study in a highly exposed population","volume":"19","author":"D Lazovich","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jaad.2013.11.050","article-title":"The association of indoor tanning and melanoma in adults: systematic review and meta-analysis","volume":"70","author":"S Colantonio","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/jmg.2006.043802","article-title":"Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents","volume":"44","author":"AM Goldstein","year":"2007","journal-title":"J Med Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.canlet.2004.12.033","article-title":"Cutaneous melanoma susceptibility and progression genes","volume":"230","author":"FA De Snoo","year":"2005","journal-title":"Cancer Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng0196-97","article-title":"Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma","volume":"12","author":"L Zuo","year":"1996","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng.910","article-title":"Germline mutations in BAP1 predispose to melanocytic tumors","volume":"43","author":"T Wiesner","year":"2011","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ng.2947","article-title":"POT1 loss-of-function variants predispose to familial melanoma","volume":"46","author":"CD Robles-Espinoza","year":"2014","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju408","article-title":"Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma","volume":"107","author":"L Aoude","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT Promoter Mutations in Familial and Sporadic Melanoma","volume":"339","author":"S Horn","year":"2013","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng.2941","article-title":"Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma","volume":"46","author":"J Shi","year":"2014","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/jmedgenet-2012-101455","article-title":"Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants","volume":"50","author":"HE Puntervoll","year":"2013","journal-title":"J Med Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/jmedgenet-2011-100281","article-title":"CDKN2A is the main susceptibility gene in Italian pancreatic cancer families","volume":"49","author":"P Ghiorzo","year":"2012","journal-title":"J Med Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/humu.9247","article-title":"Familial melanoma, pancreatic cancer and germline CDKN2A mutations","volume":"23","author":"AM Goldstein","year":"2004","journal-title":"Hum Mutat"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/ijc.23396","article-title":"MC1R variants, melanoma and red hair color phenotype: a meta-analysis","volume":"122","author":"S Raimondi","year":"2008","journal-title":"Int J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1677\/joe.0.1370189","article-title":"Effects of melanocyte-stimulating hormone on tyrosinase expression and melanin synthesis in hair follicular melanocytes of the mouse","volume":"137","author":"SA Burchill","year":"1993","journal-title":"J Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1749-6632.2003.tb03199.x","article-title":"Genetic association and cellular function of MC1R variant alleles in human pigmentation","volume":"994","author":"RA Sturm","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/pcmr.12257","article-title":"MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation","volume":"27","author":"JC Garc\u00eda-Borr\u00f3n","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/pcmr.12199","article-title":"Red human hair pheomelanin is a potent pro-oxidant mediating UV-independent contributory mechanisms of melanomagenesis","volume":"27","author":"L Panzella","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature10630","article-title":"A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma","volume":"480","author":"S Yokoyama","year":"2011","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature10539","article-title":"A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma","volume":"480","author":"C Bertolotto","year":"2011","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ng.161","article-title":"ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma","volume":"40","author":"DF Gudbjartsson","year":"2008","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1755-148X.2010.00730.x","article-title":"Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysis","volume":"23","author":"MR Gerstenblith","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/ng.959","article-title":"Genome-wide association study identifies three new melanoma susceptibility loci","volume":"43","author":"JH Barrett","year":"2011","journal-title":"Nat Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.hoc.2012.08.004","article-title":"Epidemiology and management of uveal melanoma","volume":"26","author":"Y Yonekawa","year":"2012","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.ophtha.2007.01.032","article-title":"Incidence of uveal melanoma in Europe","volume":"114","author":"G Virgili","year":"2007","journal-title":"Ophthalmology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/archopht.124.1.54","article-title":"The association between host susceptibility factors and uveal melanoma: a meta-analysis","volume":"124","author":"E Weis","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"ref33","unstructured":"Wadt KAW, Aoude LG, Johansson P, Solinas A, Pritchard A, Crainic O, et al. A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clin Genet. 2014; (Epub ahead of print) Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25225168\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25225168<\/ext-link>"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/annonc\/mdt135","article-title":"Well-differentiated papillary mesothelioma: Clustering in a Portuguese family with a germline BAP1 mutation","volume":"24","author":"C Ribeiro","year":"2013","journal-title":"Ann Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrc3459","article-title":"BAP1 and cancer","volume":"13","author":"M Carbone","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/gcc.10286","article-title":"CDKN2A as a uveal and cutaneous melanoma susceptibility gene","volume":"38","author":"C Kannengiesser","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/CMR.0b013e328343eca2","article-title":"Melanoma candidate genes CDKN2A\/p16\/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition","volume":"21","author":"MH Abdel-Rahman","year":"2011","journal-title":"Melanoma Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1086\/513891","article-title":"Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12\u201313","volume":"61","author":"DF Easton","year":"1997","journal-title":"Am J Hum Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/(SICI)1097-0215(19990730)82:3<325::AID-IJC3>3.0.CO;2-G","article-title":"Germline brca2 sequence variants in patients with ocular melanoma","volume":"82","author":"OM Sinilnikova","year":"1999","journal-title":"Int J Cancer"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jdermsci.2007.08.006","article-title":"Germline CDKN2A\/p16 mutations are rare in multiple primary and familial malignant melanoma in German patients","volume":"49","author":"A Lukowsky","year":"2008","journal-title":"J Dermatol Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/CMR.0b013e3283608695","article-title":"Analysis of Latvian familial melanoma patients shows novel variants in the noncoding regions of CDKN2A and that the CDK4 mutation R24H is a founder mutation","volume":"23","author":"R Veinalde","year":"2013","journal-title":"Melanoma Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/humu.21019","article-title":"High-resolution melting analysis (HRMA): more than just sequence variant screening","volume":"30","author":"RHAM Vossen","year":"2009","journal-title":"Hum Mutat"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1038\/ncomms6348","article-title":"A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility","volume":"5","author":"C Christensen","year":"2014","journal-title":"Nat Commun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1038\/sj.onc.1208678","article-title":"A mutation hotspot at the p14ARF splice site","volume":"24","author":"M Harland","year":"2005","journal-title":"Oncogene"},{"key":"ref45","article-title":"CDKN2A-mutation in a family with hereditary malignant melanoma","volume":"176","author":"M Djursby","year":"2014","journal-title":"Ugeskr Laeger"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"E Hodis","year":"2012","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Scaini MC, Minervini G, Elefanti L, Ghiorzo P, Pastorino L, Tognazzo S, et al. CDKN2A Unclassified Variants in Familial Malignant Melanoma: Combining Functional and Computational Approaches for Their Assessment. Hum Mutat. 2014","DOI":"10.1002\/humu.22550"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ajhg.2013.11.005","article-title":"Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes","volume":"93","author":"KE Lohmueller","year":"2013","journal-title":"Am J Hum Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/jmedgenet-2014-102320","article-title":"High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families","volume":"51","author":"H Helgadottir","year":"2014","journal-title":"J Med Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/jnci\/91.5.446","article-title":"CDKN2A variants in a population-based sample of Queensland families with melanoma","volume":"91","author":"J Aitken","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/jnci\/94.12.894","article-title":"Geographical variation in the penetrance of CDKN2A mutations for melanoma","volume":"94","author":"DT Bishop","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e72144","DOI":"10.1371\/journal.pone.0072144","article-title":"A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers","volume":"8","author":"LG Aoude","year":"2013","journal-title":"PLoS One"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/pcmr.12006","article-title":"A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma","volume":"25","author":"K Wadt","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/jnci\/dji312","article-title":"Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample","volume":"97","author":"CB Begg","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/323412","article-title":"MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations","volume":"69","author":"NF Box","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1136\/jmedgenet-2011-100563","article-title":"Indication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas","volume":"49","author":"F Harinck","year":"2012","journal-title":"J Med Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/ejhg.2010.198","article-title":"Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling","volume":"19","author":"RR McWilliams","year":"2011","journal-title":"Eur J Hum Genet"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10689-010-9329-6","article-title":"Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families","volume":"9","author":"EP Slater","year":"2010","journal-title":"Fam Cancer"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e35295","DOI":"10.1371\/journal.pone.0035295","article-title":"Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families","volume":"7","author":"CNJ Njauw","year":"2012","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/ijc.25804","article-title":"Melanocortin 1 receptor and risk of cutaneous melanoma: a meta-analysis and estimates of population burden","volume":"129","author":"PF Williams","year":"2011","journal-title":"Int J Cancer"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Hu H-H, Benfodda M, Dumaz N, Gazal S, Descamps V, Bourillon A, et al. A large french case-control study emphasizes the role of rare Mc1R variants in melanoma risk. Biomed Res Int. 2014; 925716.","DOI":"10.1155\/2014\/925716"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/pcmr.12047","article-title":"Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history","volume":"26","author":"P Ghiorzo","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cancergen.2014.03.003","article-title":"Prevalence of the E318K and V320I MITF germline mutations in Polish cancer patients and multiorgan cancer risk-a population-based study","volume":"207","author":"T Gromowski","year":"2014","journal-title":"Cancer Genet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ejca.2010.01.027","article-title":"MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis","volume":"46","author":"MC Fargnoli","year":"2010","journal-title":"Eur J Cancer"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1600-0625.2012.01549.x","article-title":"MC1R variation and melanoma risk in relation to host\/clinical and environmental factors in CDKN2A positive and negative melanoma patients","volume":"21","author":"P Ghiorzo","year":"2012","journal-title":"Exp Dermatol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ajhg.2013.04.012","article-title":"Germline BAP1 mutations predispose to renal cell carcinomas","volume":"92","author":"T Popova","year":"2013","journal-title":"Am J Hum Genet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00008390-199608000-00006","article-title":"Accuracy of case-reported family history of melanoma in Queensland, Australia","volume":"6","author":"JF Aitken","year":"1996","journal-title":"Melanoma Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:28:30Z","timestamp":1566469710000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122662"}},"subtitle":[],"editor":[{"given":"Soheil S.","family":"Dadras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,24]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122662","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,24]]}}}