{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:23:35Z","timestamp":1788780215446,"version":"build-2803163510"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0123208","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T18:10:57Z","timestamp":1430158257000},"page":"e0123208","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bmi1 Essentially Mediates Podocalyxin-Enhanced Cisplatin Chemoresistance in Oral Tongue Squamous Cell Carcinoma"],"prefix":"10.1371","volume":"10","author":[{"given":"Yueying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baisheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Munnee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.yexcr.2013.05.014","article-title":"Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition","volume":"319","author":"Y Xing","year":"2013","journal-title":"Exp Cell Res"},{"key":"ref2","first-page":"1","article-title":"Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults","volume":"42","author":"KK Choi","year":"2009","journal-title":"Oral Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1726-4901(09)70312-0","article-title":"Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome","volume":"69","author":"HH Su","year":"2006","journal-title":"J Chin Med Assoc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3322\/caac.21149","article-title":"Cancer treatment and survivorship statistics, 2012","volume":"62","author":"R Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer","volume":"324","year":"1991","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11864-011-0176-y","article-title":"Current treatment options for metastatic head and neck cancer","volume":"13","author":"KA Price","year":"2012","journal-title":"Curr Treat Options Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3322\/canjclin.45.1.8","article-title":"Cancer statistics, 1995","volume":"45","author":"PA Wingo","year":"1995","journal-title":"CA Cancer J Clin"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.oraloncology.2010.02.002","article-title":"microRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines","volume":"46","author":"ZW Yu","year":"2010","journal-title":"Oral Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/16476","article-title":"The oncogene and polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus","volume":"397","author":"JJ Jacobs","year":"1999","journal-title":"Nature"},{"key":"ref10","article-title":"Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer","author":"Z Li","year":"2014","journal-title":"Lab Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1681\/ASN.2008070782","article-title":"The role of podocalyxin in health and disease","volume":"20","author":"JS Nielsen","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"218e25","DOI":"10.1016\/j.bcmd.2006.09.001","article-title":"Podocalyxin is expressed in normal and leukemic monocytes","volume":"37","author":"R Riccioni","year":"2006","journal-title":"Blood Cells Mol Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"134e42","DOI":"10.1309\/7BHLAHHU0N4MHT7Q","article-title":"Podocalyxin: a marker of blasts in acute leukemia","volume":"124","author":"TW Kelley","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1228e9","DOI":"10.1136\/jcp.2008.059956","article-title":"Podocalyxin expression in undifferentiated thyroid carcinomas","volume":"61","author":"H Yasuoka","year":"2008","journal-title":"J Clin Pathol"},{"key":"ref15","first-page":"3050e61","article-title":"Podocalyxin EBP50 ezrin molecular complex enhancesthe metastatic potential of renal cell carcinoma through recruiting Rac1 guanine nucleotide exchange factor ARHGEF7","volume":"176","author":"YH Hsu","year":"2010","journal-title":"Am J Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6183e91","DOI":"10.1158\/0008-5472.CAN-06-3575","article-title":"Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin","volume":"67","author":"S Sizemore","year":"2007","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5068e73","DOI":"10.1158\/0008-5472.CAN-04-0240","article-title":"Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression","volume":"64","author":"A Somasiri","year":"2004","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3892\/etm.2013.957","article-title":"Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide","volume":"5","author":"H Wu","year":"2013","journal-title":"Exp Ther Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1523\/JNEUROSCI.3102-07.2007","article-title":"Inflammation activates the interferon signaling pathways in taste bud cells","volume":"27","author":"H Wang","year":"2007","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3727\/096504011X13079697132790","article-title":"Combretastatin A4 phosphate induces programmed cell death in vascular endothelial cells","volume":"19","author":"X Ding","year":"2011","journal-title":"Oncol Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e37917","DOI":"10.1371\/journal.pone.0037917","article-title":"Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer&apos;s disease","volume":"7","author":"K Byun","year":"2012","journal-title":"PLoS ONE"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1021\/jm800483v","article-title":"A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth","volume":"51","author":"VM Golubovskaya","year":"2008","journal-title":"J Med Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/carcin\/bgu139","article-title":"Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1\/Cdc42\/cortactin signaling in breast cancer cells","volume":"35","author":"CW Lin","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3892\/ijo.2014.2427","article-title":"Podocalyxin-like 1 is associated with tumor aggressiveness and metastatic gene expression in human oral squamous cell carcinoma","volume":"45","author":"CW Lin","year":"2014","journal-title":"Int J Oncol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1600-0714.2008.00728.x","article-title":"Increased expression of focal adhesion kinase correlates with cellular proliferation and apoptosis during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis","volume":"38","author":"J Xia","year":"2009","journal-title":"J Oral Pathol Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.oraloncology.2012.05.019","article-title":"Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma","volume":"48","author":"N Kurio","year":"2012","journal-title":"Oral Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/222385a0","article-title":"Platinum Compounds: a New Class of Potent Antitumour Agents","volume":"222","author":"B Rosenberg","year":"1969","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.stem.2011.05.004","article-title":"Functional crosstalk between Bmi1 and MLL\/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells","volume":"8","author":"LL Smith","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1158\/0008-5472.CAN-07-5882","article-title":"The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma","volume":"68","author":"T Chiba","year":"2008","journal-title":"Cancer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijbs.10405","article-title":"Bmi1 Drives Stem-Like Properties and is Associated with Migration, Invasion, and Poor Prognosis in Tongue Squamous Cell Carcinoma","volume":"11","author":"Q He","year":"2015","journal-title":"Int J Biol Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0123208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T05:05:44Z","timestamp":1566623144000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0123208"}},"subtitle":[],"editor":[{"given":"Roger","family":"Chammas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0123208","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}