{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:38:03Z","timestamp":1788255483362,"version":"build-2803163510"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0123659","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T20:36:11Z","timestamp":1429302971000},"page":"e0123659","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunization with a Live Attenuated H7N9 Influenza Vaccine Protects Mice against Lethal Challenge"],"prefix":"10.1371","volume":"10","author":[{"given":"Xiaolan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqiang","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongpeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcai","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaogeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"issue":"7468","key":"ref1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature12391","article-title":"Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice","volume":"501","author":"JA Belser","year":"2013","journal-title":"Nature"},{"issue":"20","key":"ref2","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1304459","article-title":"Human infection with a novel avian-origin influenza A (H7N9) virus","volume":"368","author":"R Gao","year":"2013","journal-title":"The New England journal of medicine"},{"issue":"9","key":"ref3","first-page":"880","article-title":"Human infection with H7N9 virus","volume":"369","author":"Y Shu","year":"2013","journal-title":"The New England journal of medicine"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4161\/hv.8.1.18859","article-title":"New technologies for influenza vaccines","volume":"8","author":"PR Dormitzer","year":"2012","journal-title":"Human vaccines & immunotherapeutics"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.vaccine.2010.11.026","article-title":"Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets","volume":"29","author":"P Yang","year":"2011","journal-title":"Vaccine"},{"issue":"44","key":"ref6","doi-asserted-by":"crossref","first-page":"7849","DOI":"10.1016\/j.vaccine.2011.07.093","article-title":"Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses","volume":"29","author":"PA Lanthier","year":"2011","journal-title":"Vaccine"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.vaccine.2012.12.072","article-title":"Cold-adapted X-31 live attenuated 2009 pandemic H1N1 influenza vaccine elicits protective immune responses in mice and ferrets","volume":"31","author":"YH Jang","year":"2013","journal-title":"Vaccine"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00705-010-0719-8","article-title":"Master donor viruses A\/Leningrad\/134\/17\/57 (H2N2) and B\/USSR\/60\/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model","volume":"155","author":"JT Voeten","year":"2010","journal-title":"Archives of virology"},{"issue":"13","key":"ref9","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1073\/pnas.90.13.6032","article-title":"Molecular and biological changes in the cold-adapted "master strain" A\/AA\/6\/60 (H2N2) influenza virus","volume":"90","author":"ML Herlocher","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"24","key":"ref10","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1305584","article-title":"Clinical findings in 111 cases of influenza A (H7N9) virus infection","volume":"368","author":"HN Gao","year":"2013","journal-title":"The New England journal of medicine"},{"key":"ref11","first-page":"99","article-title":"Reverse genetics of the avian influenza virus","volume":"436","author":"CW Lee","year":"2008","journal-title":"Methods in molecular biology"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1371\/journal.pmed.0030360","article-title":"Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets","volume":"3","author":"AL Suguitan Jr","year":"2006","journal-title":"PLoS medicine"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/cmi.2009.116","article-title":"Response of BALB\/c mice to a monovalent influenza A (H1N1) 2009 split vaccine","volume":"7","author":"P Yang","year":"2010","journal-title":"Cellular & molecular immunology"},{"issue":"17\u201318","key":"ref14","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/S0264-410X(02)00809-5","article-title":"Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate","volume":"21","author":"H Chen","year":"2003","journal-title":"Vaccine"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/viro.2002.1742","article-title":"Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics","volume":"305","author":"K Subbarao","year":"2003","journal-title":"Virology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/JVI.01775-08","article-title":"Evaluation of live attenuated influenza a virus h6 vaccines in mice and ferrets","volume":"83","author":"Z Chen","year":"2009","journal-title":"J Virol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1128\/JVI.00100-14","article-title":"Development of a high-yield live attenuated H7N9 influenza virus vaccine that provides protection against homologous and heterologous H7 wild-type viruses in ferrets","volume":"88","author":"Z Chen","year":"2014","journal-title":"J Virol"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1128\/CVI.00272-14","article-title":"An H7N1 influenza virus vaccine induces broadly reactive antibody responses against H7N9 in humans","volume":"21","author":"F Krammer","year":"2014","journal-title":"Clinical and vaccine immunology: CVI"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1128\/JVI.03095-13","article-title":"Divergent H7 immunogens offer protection from H7N9 virus challenge","volume":"88","author":"F Krammer","year":"2014","journal-title":"J Virol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.virol.2008.05.021","article-title":"A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets","volume":"378","author":"T Joseph","year":"2008","journal-title":"Virology"},{"issue":"28","key":"ref21","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1016\/j.vaccine.2009.03.082","article-title":"A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults","volume":"27","author":"KR Talaat","year":"2009","journal-title":"Vaccine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0123659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T02:27:36Z","timestamp":1540348056000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0123659"}},"subtitle":[],"editor":[{"given":"Matthias Johannes","family":"Schnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,17]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0123659","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,17]]}}}