{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:35:35Z","timestamp":1785893735858,"version":"3.56.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0123661","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T18:54:30Z","timestamp":1429124070000},"page":"e0123661","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues"],"prefix":"10.1371","volume":"10","author":[{"given":"Charlotte","family":"Welinder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Paw\u0142owski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yakovleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"J\u00f6nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ingvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Baldetorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Rezeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Laurell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fehniger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"D\u00f6me","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Malm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Wieslander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Marko-Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"issue":"36","key":"ref1","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"CM Balch","year":"2009","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.sder.2010.06.004","article-title":"Implications of the 2009 American Joint Committee on Cancer Melanoma Staging and Classification on dermatologists and their patients","volume":"29","author":"MA Nading","year":"2010","journal-title":"Seminars in cutaneous medicine and surgery"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00000658-197011000-00017","article-title":"Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma","volume":"172","author":"A Breslow","year":"1970","journal-title":"Annals of surgery"},{"key":"ref4","first-page":"647684","article-title":"Metastatic behavior in melanoma: timing, pattern, survival, and influencing factors","volume":"2012","author":"F Tas","year":"2012","journal-title":"Journal of oncology"},{"issue":"17\u201318","key":"ref5","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/pmic.201300476","article-title":"A new look at drugs targeting malignant melanoma-An application for mass spectrometry imaging","volume":"14","author":"Y Sugihara","year":"2014","journal-title":"Proteomics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1479-5876-10-85","article-title":"The role of BRAF V600 mutation in melanoma","volume":"10","author":"PA Ascierto","year":"2012","journal-title":"Journal of translational medicine"},{"issue":"26","key":"ref7","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","article-title":"Improved survival with vemurafenib in melanoma with BRAF V600E mutation","volume":"364","author":"PB Chapman","year":"2011","journal-title":"The New England journal of medicine"},{"issue":"7315","key":"ref8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature09454","article-title":"Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma","volume":"467","author":"G Bollag","year":"2010","journal-title":"Nature"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with ipilimumab in patients with metastatic melanoma","volume":"363","author":"FS Hodi","year":"2010","journal-title":"The New England journal of medicine"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1158\/1078-0432.CCR-13-3122","article-title":"BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact","volume":"20","author":"H Rizos","year":"2014","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"7494","key":"ref11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature13121","article-title":"Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma","volume":"508","author":"C Sun","year":"2014","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"181890","DOI":"10.1155\/2011\/181890","article-title":"Proteomics in melanoma biomarker discovery: great potential, many obstacles","volume":"2011","author":"MS Sabel","year":"2011","journal-title":"International journal of proteomics"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/bjc.2014.169","article-title":"Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance","volume":"110","author":"A Azimi","year":"2014","journal-title":"British journal of cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-62703-727-3_11","article-title":"Current status of diagnostic and prognostic markers in melanoma","volume":"1102","author":"D Levine","year":"2014","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"issue":"13","key":"ref15","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1158\/1078-0432.CCR-09-2509","article-title":"Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome","volume":"16","author":"G Jonsson","year":"2010","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1755-148X.2008.00505.x","article-title":"Novel MITF targets identified using a two-step DNA microarray strategy","volume":"21","author":"KS Hoek","year":"2008","journal-title":"Pigment cell & melanoma research"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/jnci\/djj103","article-title":"Gene expression profiling of primary cutaneous melanoma and clinical outcome","volume":"98","author":"V Winnepenninckx","year":"2006","journal-title":"Journal of the National Cancer Institute"},{"issue":"17","key":"ref18","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1073\/pnas.0501564102","article-title":"The gene expression signatures of melanoma progression","volume":"102","author":"C Haqq","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1755-148X.2012.00986.x","article-title":"Systematic classification of melanoma cells by phenotype-specific gene expression mapping","volume":"25","author":"DS Widmer","year":"2012","journal-title":"Pigment cell & melanoma research"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/clinchem\/47.10.1901","article-title":"Proteomics in early detection of cancer","volume":"47","author":"PR Srinivas","year":"2001","journal-title":"Clinical chemistry"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4172\/jpb.1000260","article-title":"Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma","volume":"6","author":"SD Byrum","year":"2013","journal-title":"Journal of proteomics & bioinformatics"},{"key":"ref22","unstructured":"Baldetorp B. PROFILE: Malignant melanoma initiative in southern Sweden. PUBLIC SERVICE REVIEW. 2013(25)."},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2001-1326-2-7","article-title":"Establishing a Southern Swedish Malignant Melanoma OMICS and biobank clinical capability","volume":"2","author":"C Welinder","year":"2013","journal-title":"Clinical and translational medicine"},{"issue":"23","key":"ref24","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1021\/ac010617e","article-title":"An automated multidimensional protein identification technology for shotgun proteomics","volume":"73","author":"DA Wolters","year":"2001","journal-title":"Analytical chemistry"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/path.4318","article-title":"Molecular and genetic diversity in the metastatic process of melanoma","volume":"233","author":"K Harbst","year":"2014","journal-title":"The Journal of pathology"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Cirenajwis H, Ekedahl H, Martin Lauss M, Harbst K, Carneiro A, Enoksson J, et al. Molecular stratification of metastatic melanoma using gene expression profiling\u2014prediction of survival outcome and benefit from molecular targeted therapy. (submitted). 2015.","DOI":"10.18632\/oncotarget.3655"},{"key":"ref27","article-title":"Histopathologic technic and practical histochemistry","author":"RD Lillie","year":"1965"},{"key":"ref28","article-title":"Histochemical Uses Of Haematoxylin","volume":"1","author":"G Avwioro","year":"2011","journal-title":"J Pharmacy and Clinical Sciences"},{"issue":"3","key":"ref29","first-page":"223","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"JA Vizcaino","year":"2014","journal-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nature protocols"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn\u2014a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"T Hulsen","year":"2008","journal-title":"BMC genomics"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jchromb.2003.07.015","article-title":"Automated multi-dimensional liquid chromatography: sample preparation and identification of peptides from human blood filtrate","volume":"803","author":"E Machtejevas","year":"2004","journal-title":"Journal of chromatography B, Analytical technologies in the biomedical and life sciences"},{"issue":"13","key":"ref33","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/jssc.200900058","article-title":"Profiling of endogenous peptides by multidimensional liquid chromatography: On-line automated sample cleanup for biomarker discovery in human urine","volume":"32","author":"E Machtejevas","year":"2009","journal-title":"Journal of separation science"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1021\/ac010627f","article-title":"An automated on-line multidimensional HPLC system for protein and peptide mapping with integrated sample preparation","volume":"74","author":"K Wagner","year":"2002","journal-title":"Analytical chemistry"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1021\/la104720n","article-title":"Protein adsorption at charged surfaces: the role of electrostatic interactions and interfacial charge regulation","volume":"27","author":"RA Hartvig","year":"2011","journal-title":"Langmuir: the ACS journal of surfaces and colloids"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1021\/pr300375d","article-title":"Combinatorial use of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) and strong cation exchange (SCX) chromatography for in-depth phosphoproteome analysis","volume":"11","author":"M Zarei","year":"2012","journal-title":"Journal of proteome research"},{"issue":"15","key":"ref37","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1158\/1078-0432.CCR-12-0343","article-title":"Molecular profiling reveals low- and high-grade forms of primary melanoma","volume":"18","author":"K Harbst","year":"2012","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"e10481","DOI":"10.1371\/journal.pone.0010481","article-title":"Parkinson&apos;s disease-related protein, alpha-synuclein, in malignant melanoma","volume":"5","author":"Y Matsuo","year":"2010","journal-title":"PloS one"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"e110804","DOI":"10.1371\/journal.pone.0110804","article-title":"Analysis of Alpha-Synuclein in Malignant Melanoma\u2014Development of a SRM Quantification Assay","volume":"9","author":"C Welinder","year":"2014","journal-title":"PloS one"},{"key":"ref40","article-title":"Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients","author":"S Mactier","year":"2014","journal-title":"Pigment cell & melanoma research"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1021\/pr9006365","article-title":"Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry","volume":"9","author":"DL Tabb","year":"2010","journal-title":"Journal of proteome research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0123661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T22:53:48Z","timestamp":1598914428000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0123661"}},"subtitle":[],"editor":[{"given":"Yiqun G.","family":"Shellman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,13]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0123661","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,13]]}}}