{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:10:15Z","timestamp":1792113015603,"version":"4.4.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0123757","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T15:05:42Z","timestamp":1429110342000},"page":"e0123757","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Evidence for Chronic Low-Grade Systemic Inflammation in Individuals with Agoraphobia from a Population-Based Prospective Study"],"prefix":"10.1371","volume":"10","author":[{"given":"En-Young N.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan T.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Glaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L.","family":"Vandeleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Castelao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre F.","family":"Strippoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bbi.2006.01.001","article-title":"Inflammatory and hemostatic responses to repeated mental stress: individual stability and habituation over time","volume":"20","author":"M Hamer","year":"2006","journal-title":"Brain Behav Immun"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jpsychires.2006.06.009","article-title":"Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder","volume":"41","author":"R von K\u00e4nel","year":"2007","journal-title":"J Psychiatr Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1744-6163.2009.00229.x","article-title":"PTSD is associated with an excess of inflammatory immune activities","volume":"5","author":"JM Gill","year":"2009","journal-title":"Perspect Psychiatr Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbi.2010.10.003","article-title":"A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities","volume":"25","author":"TW Pace","year":"2011","journal-title":"Brain Behav Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbi.2012.08.015","article-title":"Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions","volume":"30","author":"M van Zuiden","year":"2013","journal-title":"Brain Behav Immun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1810","article-title":"Neural regulation of innate immunity: A coordinated nonspecific host response to pathogens","volume":"6","author":"EM Sternberg","year":"2006","journal-title":"Nature Reviews Immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.psyneuen.2007.07.001","article-title":"Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident","volume":"32","author":"P Pervanidou","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1176\/appi.ajp.160.9.1554","article-title":"When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders","volume":"160","author":"CL Raison","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000087104","article-title":"Cytokine dysregulation, inflammation and well-being","volume":"12","author":"IJ Elenkov","year":"2005","journal-title":"Neuroimmunomodulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: Central role of the brain","volume":"87","author":"BS McEwen","year":"2007","journal-title":"Physiological Reviews"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/jamapsychiatry.2013.4374","article-title":"Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk","volume":"71","author":"SA Eraly","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jts.20429","article-title":"The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands","volume":"22","author":"GJ de Vries","year":"2009","journal-title":"J Trauma Stress"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/da.20564","article-title":"Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder","volume":"26","author":"EA Hoge","year":"2009","journal-title":"Depress Anxiety"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1093\/eurheartj\/ehn326","article-title":"Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients","volume":"29","author":"B Bankier","year":"2008","journal-title":"Eur Heart J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1600-0447.2005.00684.x","article-title":"Functional disability of mental disorders and comparison with physical disorders: a study among the general population of six European countries","volume":"113","author":"MA Buist-Bouwman","year":"2006","journal-title":"Acta Psychiatr Scand"},{"key":"ref16","first-page":"77","article-title":"Stress-Induced and Fear Circuitry Disorders Refining the Research Agenda for DSM-V","author":"PMG Emmelkamp","year":"2009"},{"key":"ref17","article-title":"Diagnostic and Statistical Manual of Mental Disorders Text Revision","year":"2000"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/da.20646","article-title":"Agoraphobia: a review of the diagnostic classificatory position and criteria","volume":"27","author":"HU Wittchen","year":"2010","journal-title":"Depress Anxiety"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/0006-3223(86)90242-8","article-title":"Immunological response to stress in agoraphobia and panic attacks","volume":"21","author":"OS Surman","year":"1986","journal-title":"Biol Psychiatr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1038\/tp.2013.27","article-title":"Anxiety disorders and inflammation in a large adult cohort","volume":"3","author":"N Vogelzangs","year":"2013","journal-title":"Transl Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.metabol.2013.06.004","article-title":"Adipocytokines in relation to cardiovascular disease","volume":"62","author":"J Van de Voorde","year":"2013","journal-title":"Metabolism"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2261-8-6","article-title":"The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome","volume":"8","author":"M Firmann","year":"2008","journal-title":"BMC Cardiovasc Disord"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-244X-9-9","article-title":"The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors","volume":"9","author":"M Preisig","year":"2009","journal-title":"BMC Psychiatry"},{"key":"ref24","author":"DP Goldberg","year":"1972"},{"key":"ref25","article-title":"L'\u00e9valuation clinique standardis\u00e9e en psychiatrie Tome I","volume":"1","author":"W Bettschart","year":"1996"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archpsyc.1994.03950110009002","article-title":"Diagnostic interview for genetic studies. Rationale, unique features, and training","volume":"51","author":"JI Nurnberger Jr","year":"1994","journal-title":"NIMH Genetics Initiative. Arch Gen Psychiatry"},{"key":"ref27","author":"M Leboyer","year":"1995"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s004060050084","article-title":"Diagnostic interview for genetic studies (DIGS): interrater and test-retest reliability of the French version","volume":"249","author":"M Preisig","year":"1999","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0376-8716(01)00156-9","article-title":"Diagnostic interview for genetic studies (DIGS): interrater and test-retest reliability of alcohol and drug diagnoses","volume":"65","author":"A Berney","year":"2002","journal-title":"Drug Alcohol Depend"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.psychres.2006.04.022","article-title":"Inter-informant agreement on diagnoses and prevalence estimates of anxiety disorders: direct interview versus family history method","volume":"157","author":"A Rougemont-Buecking","year":"2008","journal-title":"Psychiatry Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1006\/cyto.2000.0764","article-title":"Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin","volume":"12","author":"L Flower","year":"2000","journal-title":"Cytokine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1515\/CCLM.2008.219","article-title":"Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations?","volume":"46","author":"M Skeppholm","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0022-1759(00)00238-6","article-title":"Multiplexed particle-based flow cytometric assays","volume":"243","author":"DA Vignali","year":"2000","journal-title":"J Immunol Methods"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jri.2005.03.005","article-title":"Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants","volume":"66","author":"NC Dupont","year":"2005","journal-title":"J Reprod Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ymeth.2005.11.010","article-title":"Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA","volume":"38","author":"MF Elshal","year":"2006","journal-title":"Methods"},{"key":"ref36","first-page":"i","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation","volume":"894","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"ref37","author":"AB Hollingshead","year":"1975"},{"key":"ref38","first-page":"5","article-title":"What is moderate drinking? Defining drinks and drinking levels","volume":"23","author":"MC Dufour","year":"1999","journal-title":"Alcohol Res Health"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/oxfordjournals.aje.a115960","article-title":"The assessment of alcohol consumption by a simple self-administered questionnaire","volume":"133","author":"E Giovannucci","year":"1991","journal-title":"Am J Epidemiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbi.2012.02.003","article-title":"Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study","volume":"26","author":"A O'Donovan","year":"2012","journal-title":"Brain Behav Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What\u2019s wrong with Bonferroni adjustments","volume":"316","author":"TV Perneger","year":"1998","journal-title":"BMJ"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"KJ Rothman","year":"1990","journal-title":"Epidemiology"},{"issue":"Suppl B","key":"ref43","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/S1550-8579(07)80057-X","article-title":"Anxiety disorders: sex differences in prevalence, degree, and background, but gender-neutral treatment","volume":"4","author":"MH Bekker","year":"2007","journal-title":"Gend Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jacc.2010.03.034","article-title":"Anxiety and risk of incident coronary heart disease: a meta-analysis","volume":"56","author":"AM Roest","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"S Kaptoge","year":"2010","journal-title":"Lancet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/eurheartj\/eht367","article-title":"Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis","volume":"35","author":"S Kaptoge","year":"2014","journal-title":"Eur Heart J"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/01.CIR.103.13.1718","article-title":"Inflammation and thrombosis: the clot thickens","volume":"103","author":"P Libby","year":"2001","journal-title":"Circulation"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"P Libby","year":"2002","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrcardio.2012.45","article-title":"Stress and cardiovascular disease","volume":"9","author":"A Steptoe","year":"2012","journal-title":"Nat Rev Cardiol"},{"key":"ref50","first-page":"w13502","article-title":"Psychosocial stress and cardiovascular risk: current opinion","volume":"142","author":"R von K\u00e4nel","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbi.2006.09.006","article-title":"Twenty years of research on cytokine-induced sickness behavior","volume":"21","author":"R Dantzer","year":"2007","journal-title":"Brain Behav Immun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0123757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:38:48Z","timestamp":1540309128000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0123757"}},"subtitle":[],"editor":[{"given":"Monica","family":"Uddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,13]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0123757","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,13]]}}}