{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:03:50Z","timestamp":1789913030144,"version":"4.0.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0123965","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T19:29:30Z","timestamp":1428694170000},"page":"e0123965","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Requirement of DLG1 for Cardiovascular Development and Tissue Elongation during Cochlear, Enteric, and Skeletal Development: Possible Role in Convergent Extension"],"prefix":"10.1371","volume":"10","author":[{"given":"Akiko","family":"Iizuka-Kogo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Senda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shimomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Sawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.genet.42.110807.091432","article-title":"Planar cell polarity signaling: from fly development to human disease","volume":"42","author":"M Simons","year":"2008","journal-title":"Annu Rev Genet"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"e8999","DOI":"10.1371\/journal.pone.0008999","article-title":"Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis","volume":"5","author":"D Antic","year":"2010","journal-title":"PloS one"},{"issue":"6936","key":"ref3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature01618","article-title":"Identification of Vangl2 and Scrb1 as planar polarity genes in mammals","volume":"423","author":"M Montcouquiol","year":"2003","journal-title":"Nature"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/ng1622","article-title":"Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway","volume":"37","author":"J Wang","year":"2005","journal-title":"Nat Genet"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1242\/dev.02772","article-title":"Tissue\/planar cell polarity in vertebrates: new insights and new questions","volume":"134","author":"Y Wang","year":"2007","journal-title":"Development"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/hh1301.092497","article-title":"Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant","volume":"89","author":"DJ Henderson","year":"2001","journal-title":"Circ Res"},{"issue":"6995","key":"ref7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature02677","article-title":"PTK7\/CCK-4 is a novel regulator of planar cell polarity in vertebrates","volume":"430","author":"X Lu","year":"2004","journal-title":"Nature"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/heart.89.7.806","article-title":"Development of the heart: (1) formation of the cardiac chambers and arterial trunks","volume":"89","author":"A Moorman","year":"2003","journal-title":"Heart"},{"issue":"16","key":"ref9","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.128.16.3179","article-title":"Conotruncal myocardium arises from a secondary heart field","volume":"128","author":"KL Waldo","year":"2001","journal-title":"Development"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/dbio.1998.8860","article-title":"Cardiac neural crest cells provide new insight into septation of the cardiac outflow tract: aortic sac to ventricular septal closure","volume":"196","author":"K Waldo","year":"1998","journal-title":"Dev Biol"},{"issue":"14","key":"ref11","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1242\/dev.01214","article-title":"Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells","volume":"131","author":"V Kaartinen","year":"2004","journal-title":"Development"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/dvdy.23833","article-title":"Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept","volume":"241","author":"RW Scherptong","year":"2012","journal-title":"Dev Dyn"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/dev.02408","article-title":"Fgf8 is required for anterior heart field development","volume":"133","author":"R Ilagan","year":"2006","journal-title":"Development"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ydbio.2012.07.023","article-title":"Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis","volume":"370","author":"T Sinha","year":"2012","journal-title":"Dev Biol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1203\/pdr.0b013e3180323810","article-title":"Wnt5a is required for cardiac outflow tract septation in mice","volume":"61","author":"JR Schleiffarth","year":"2007","journal-title":"Pediatric research"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/CIRCRESAHA.106.142406","article-title":"Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization","volume":"101","author":"HM Phillips","year":"2007","journal-title":"Circ Res"},{"issue":"24","key":"ref17","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1242\/dev.00164","article-title":"Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure","volume":"129","author":"NS Hamblet","year":"2002","journal-title":"Development"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"e1000259","DOI":"10.1371\/journal.pgen.1000259","article-title":"Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development","volume":"4","author":"SL Etheridge","year":"2008","journal-title":"PLoS Genet"},{"issue":"21","key":"ref19","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1242\/dev.052001","article-title":"Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes","volume":"137","author":"H Yu","year":"2010","journal-title":"Development"},{"issue":"23","key":"ref20","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1242\/dev.083352","article-title":"Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes","volume":"139","author":"H Yu","year":"2012","journal-title":"Development"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1083\/jcb.134.6.1469","article-title":"Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia","volume":"134","author":"DF Woods","year":"1996","journal-title":"J Cell Biol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(81)90009-X","article-title":"The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions","volume":"66","author":"DF Woods","year":"1991","journal-title":"Cell"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.tcb.2006.10.005","article-title":"The Scribble and Par complexes in polarity and migration: friends or foes?","volume":"16","author":"PO Humbert","year":"2006","journal-title":"Trends in cell biology"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.cell.2005.09.043","article-title":"Microtubule-induced Pins\/Galphai cortical polarity in Drosophila neuroblasts","volume":"123","author":"SE Siegrist","year":"2005","journal-title":"Cell"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"e29611","DOI":"10.1371\/journal.pone.0029611","article-title":"Inscuteable regulates the Pins-Mud spindle orientation pathway","volume":"7","author":"JF Mauser","year":"2012","journal-title":"PloS one"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1128\/MCB.21.5.1475-1483.2001","article-title":"Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene","volume":"21","author":"G Caruana","year":"2001","journal-title":"Mol Cell Biol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00418-004-0729-2","article-title":"Colocalization of APC and DLG at the tips of cellular protrusions in cultured epithelial cells and its dependency on cytoskeletons","volume":"123","author":"A Iizuka-Kogo","year":"2005","journal-title":"Histochem Cell Biol"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1242\/dev.02830","article-title":"Abnormal development of urogenital organs in Dlgh1-deficient mice","volume":"134","author":"A Iizuka-Kogo","year":"2007","journal-title":"Development"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1523-1755.2005.00489.x","article-title":"Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney","volume":"68","author":"E Naim","year":"2005","journal-title":"Kidney Int"},{"issue":"52","key":"ref30","doi-asserted-by":"crossref","first-page":"19872","DOI":"10.1073\/pnas.0609326103","article-title":"Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter","volume":"103","author":"ZX Mahoney","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2535\/ofaj.81.25","article-title":"Fine structure of the anal tonsilliar epithelium in the laboratory shrew (Suncus murinus)","volume":"81","author":"K Sakai","year":"2004","journal-title":"Okajimas folia anatomica Japonica"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-213X-11-68","article-title":"Novel migrating mouse neural crest cell assay system utilizing P0-Cre\/EGFP fluorescent time-lapse imaging","volume":"11","author":"M Kawakami","year":"2011","journal-title":"BMC Dev Biol"},{"issue":"5264","key":"ref33","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1126\/science.272.5264.1020","article-title":"Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein","volume":"272","author":"A Matsumine","year":"1996","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Parker M, Brugeaud A, Edge AS. Primary culture and plasmid electroporation of the murine organ of Corti. Journal of visualized experiments: JoVE. 2010;(36).","DOI":"10.3791\/1685"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1242\/dev.126.8.1581","article-title":"p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti","volume":"126","author":"P Chen","year":"1999","journal-title":"Development"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/dbio.1999.9323","article-title":"A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice","volume":"212","author":"Y Yamauchi","year":"1999","journal-title":"Dev Biol"},{"issue":"18","key":"ref37","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1242\/dev.063495","article-title":"Partitioning the heart: mechanisms of cardiac septation and valve development","volume":"139","author":"CJ Lin","year":"2012","journal-title":"Development"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/63.1.39","article-title":"Sensory organ development in the inner ear: molecular and cellular mechanisms","volume":"63","author":"J Bryant","year":"2002","journal-title":"Br Med Bull"},{"issue":"19","key":"ref39","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/dev.02002","article-title":"The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear","volume":"132","author":"AE Kiernan","year":"2005","journal-title":"Development"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/bdrc.20013","article-title":"The neural crest: basic biology and clinical relationships in the craniofacial and enteric nervous systems","volume":"72","author":"PG Farlie","year":"2004","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ydbio.2008.11.020","article-title":"Wnt5a is essential for intestinal elongation in mice","volume":"326","author":"S Cervantes","year":"2009","journal-title":"Dev Biol"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/ar.22814","article-title":"Decreased apoptosis and persistence of the common nephric duct during the development of an aberrant vesicoureteral junction in Dlg1 gene-targeted mice","volume":"296","author":"A Iizuka-Kogo","year":"2013","journal-title":"Anatomical record"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/bdrc.10002","article-title":"Neural crest and cardiovascular development: a 20-year perspective","volume":"69","author":"MR Hutson","year":"2003","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2005.05.003","article-title":"Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia","volume":"284","author":"C Ward","year":"2005","journal-title":"Dev Biol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.devcel.2011.06.011","article-title":"Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity","volume":"21","author":"RS Gray","year":"2011","journal-title":"Dev Cell"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1242\/dev.00448","article-title":"Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea","volume":"130","author":"A Dabdoub","year":"2003","journal-title":"Development"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrm3723","article-title":"Cell intercalation from top to bottom","volume":"15","author":"E Walck-Shannon","year":"2014","journal-title":"Nature reviews Molecular cell biology"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.RES.0000154912.08695.88","article-title":"Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract","volume":"96","author":"HM Phillips","year":"2005","journal-title":"Circ Res"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1242\/dev.065326","article-title":"Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin","volume":"139","author":"MF Chacon-Heszele","year":"2012","journal-title":"Development"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/dvdy.22212","article-title":"Ror2 is required for midgut elongation during mouse development","volume":"239","author":"M Yamada","year":"2010","journal-title":"Dev Dyn"},{"issue":"20","key":"ref51","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1242\/dev.040592","article-title":"Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins","volume":"136","author":"MJ Ahrens","year":"2009","journal-title":"Development"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/6804","article-title":"Notch signalling pathway mediates hair cell development in mammalian cochlea","volume":"21","author":"PJ Lanford","year":"1999","journal-title":"Nat Genet"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pgen.0020004","article-title":"The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear","volume":"2","author":"AE Kiernan","year":"2006","journal-title":"PLoS Genet"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"e54410","DOI":"10.1371\/journal.pone.0054410","article-title":"Requirement for Dlgh-1 in Planar Cell Polarity and Skeletogenesis during Vertebrate Development","volume":"8","author":"C Rivera","year":"2013","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0123965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T17:04:08Z","timestamp":1651683848000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0123965"}},"subtitle":[],"editor":[{"given":"Ben","family":"Hogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,10]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0123965","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,10]]}}}