{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:28:43Z","timestamp":1790029723889,"version":"4.0.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124002","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T14:09:58Z","timestamp":1428934198000},"page":"e0124002","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Decrease of Functional Activated T and B Cells and Treatment of Glomerulonephitis in Lupus-Prone Mice Using a Natural Flavonoid Astilbin"],"prefix":"10.1371","volume":"10","author":[{"given":"Lele","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2174\/092986712803414312","article-title":"Novel and emerging drugs for systemic lupus erythematosus: mechanism of action and therapeutic activity","volume":"19","author":"E Robak","year":"2012","journal-title":"Curr Med Chem"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molmed.2009.12.005","article-title":"Pathogenesis of human systemic lupus erythematosus: recent advances","volume":"16","author":"JC Crispin","year":"2010","journal-title":"Trends Mol Med"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1615\/CritRevImmunol.v25.i2.30","article-title":"T- and B-cell abnormalities in systemic lupus erythematosus","volume":"25","author":"G Nagy","year":"2005","journal-title":"Crit Rev Immunol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1177\/0961203313499417","article-title":"Targeted therapies in systemic lupus erythematosus","volume":"22","author":"P Grech","year":"2013","journal-title":"Lupus"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1517\/14728214.2014.894018","article-title":"Emerging biological therapies for systemic lupus erythematosus","volume":"19","author":"CC Mok","year":"2014","journal-title":"Expert Opin Emerg Drugs"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1517\/14712598.2014.895810","article-title":"Update on B-cell targeted therapies for systemic lupus erythematosus","volume":"14","author":"CC Mok","year":"2014","journal-title":"Expert Opin Biol Ther"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1681\/ASN.2010050472","article-title":"Updates on the treatment of lupus nephritis","volume":"21","author":"AS Bomback","year":"2010","journal-title":"J Am Soc Nephrol: JASN"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2165\/11535420-000000000-00000","article-title":"B cell-targeted therapies for systemic lupus erythematosus: an update on clinical trial data","volume":"70","author":"RJ Looney","year":"2010","journal-title":"Drugs"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/art.10856","article-title":"A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis","volume":"48","author":"DT Boumpas","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1002\/art.27601","article-title":"The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial","volume":"62","author":"JT Merrill","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/s-1999-13963","article-title":"A new flavanone isolated from rhizoma smilacis glabrae and the structural requirements of its derivatives for preventing immunological hepatocyte damage","volume":"65","author":"T Chen","year":"1999","journal-title":"Planta Med"},{"issue":"7","key":"ref12","first-page":"382","article-title":"The in vitro inhibitory effect of flavonoid astilbin on 3-hydroxy-3-methylglutaryl coenzyme A reductase on Vero cells","volume":"64","author":"TH Chen","year":"2001","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1271\/bbb.60.945","article-title":"Protection against oxidative damage by dihydroflavonols in Engelhardtia chrysolepis","volume":"60","author":"H Haraguchi","year":"1996","journal-title":"Biosci Biotechnol Biochem"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.jaci.2005.08.032","article-title":"Astilbin inhibits contact hypersensitivity through negative cytokine regulation distinct from cyclosporin A","volume":"116","author":"M Fei","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1211\/0022357023033","article-title":"Astilbin prevents concanavalin A-induced liver injury by reducing TNF-alpha production and T lymphocytes adhesion","volume":"56","author":"J Wang","year":"2004","journal-title":"J Pharm Pharmacol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(99)00401-X","article-title":"Astilbin selectively induces dysfunction of liver-infiltrating cells\u2014novel protection from liver damage","volume":"377","author":"Q Xu","year":"1999","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/phrs.2001.0838","article-title":"Astilbin selectively facilitates the apoptosis of interleukin-2-dependent phytohemagglutinin-activated Jurkat cells","volume":"44","author":"R Yan","year":"2001","journal-title":"Pharmacol Res"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.intimp.2008.06.006","article-title":"Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-alpha and its associated MMP-9 activity and CD44 expression","volume":"8","author":"HW Yi","year":"2008","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbrc.2014.02.136","article-title":"Induction of TGF-beta and IL-10 production in dendritic cells using astilbin to inhibit dextran sulfate sodium-induced colitis","volume":"446","author":"Y Ding","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1016\/j.transproceed.2010.06.031","article-title":"Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice","volume":"42","author":"S Zou","year":"2010","journal-title":"Transplant Proc"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00011-003-1179-3","article-title":"Astilbin suppresses collagen-induced arthritis via the dysfunction of lymphocytes","volume":"52","author":"Y Cai","year":"2003","journal-title":"Inflamm Res"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1373\/clinchem.2006.077297","article-title":"Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis","volume":"53","author":"J Guo","year":"2007","journal-title":"Clin Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jchromb.2013.04.018","article-title":"Metabolite profiling of astilbin in rat sera using UPLC\/MS(E) and impact of its metabolites on immunosuppressive activity","volume":"929","author":"J Tang","year":"2013","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.4049\/jimmunol.1101228","article-title":"Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2","volume":"187","author":"LD Lu","year":"2011","journal-title":"J Immunol"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1002\/art.30392","article-title":"Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL\/lpr mice by inhibiting Th1 and Th17 cell responses","volume":"63","author":"LF Hou","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref26","first-page":"S82","article-title":"New drugs in systemic lupus erythematosus: when to start and when to stop","volume":"31","author":"M Mosca","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","article-title":"Murine models of systemic lupus erythematosus","volume":"37","author":"AN Theofilopoulos","year":"1985","journal-title":"Adv Immunol"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"e48798","DOI":"10.1371\/journal.pone.0048798","article-title":"Fas-independent T-cell apoptosis by dendritic cells controls autoimmune arthritis in MRL\/lpr mice","volume":"7","author":"T Izawa","year":"2012","journal-title":"PloS one"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10875-007-9104-0","article-title":"Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus","volume":"27","author":"HY Chun","year":"2007","journal-title":"J Clin Immunol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/art.30085","article-title":"Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium\/calmodulin-dependent protein kinase type IV","volume":"63","author":"K Ichinose","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1186\/ar4277","article-title":"Clinical associations of serum interleukin-17 in systemic lupus erythematosus","volume":"15","author":"FB Vincent","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1182\/blood-2009-12-259457","article-title":"Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow","volume":"116","author":"O Winter","year":"2010","journal-title":"Blood"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.4049\/jimmunol.1300152","article-title":"Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice","volume":"191","author":"NV Giltiay","year":"2013","journal-title":"J Immunol"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11926-012-0258-2","article-title":"The rationale for BAFF inhibition in systemic lupus erythematosus","volume":"14","author":"A Davidson","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.4049\/jimmunol.157.7.2924","article-title":"B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells","volume":"157","author":"R Roth","year":"1996","journal-title":"J Immunol"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.4049\/jimmunol.165.6.3436","article-title":"Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL\/lpr lupus","volume":"165","author":"B Liang","year":"2000","journal-title":"J Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T08:08:46Z","timestamp":1691568526000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124002"}},"subtitle":[],"editor":[{"given":"Johan","family":"van der Vlag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,13]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124002","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,13]]}}}