{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:02:38Z","timestamp":1791547358650,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124027","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T18:00:34Z","timestamp":1431540034000},"page":"e0124027","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Aberrant Function of Learning and Cognitive Control Networks Underlie Inefficient Cognitive Flexibility in Anorexia Nervosa: A Cross-Sectional fMRI Study"],"prefix":"10.1371","volume":"10","author":[{"given":"Nick P.","family":"Lao-Kaim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Fonville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Giampietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C. R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Tchanturia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.biopsych.2006.03.040","article-title":"The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication","volume":"61","author":"JI Hudson","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1192\/bjp.173.1.11","article-title":"Excess mortality of mental disorder","volume":"173","author":"EC Harris","year":"1998","journal-title":"Br J Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1348\/014466505X53902","article-title":"Anorexia nervosa: valued and visible. A cognitive-interpersonal maintenance model and its implications for research and practice","volume":"45","author":"U Schmidt","year":"2006","journal-title":"Br J Clin Psychol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e28331","DOI":"10.1371\/journal.pone.0028331","article-title":"Poor Cognitive Flexibility in Eating Disorders: Examining the Evidence using the Wisconsin Card Sorting Task","volume":"7","author":"K Tchanturia","year":"2012","journal-title":"Plos One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jpsychires.2010.03.001","article-title":"Exploring the neurocognitive signature of poor set-shifting in anorexia and bulimia nervosa","volume":"44","author":"ME Roberts","year":"2010","journal-title":"Journal of Psychiatric Research"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3109\/15622975.2010.483250","article-title":"Set-shifting abilities, central coherence, and handedness in anorexia nervosa patients, their unaffected siblings and healthy controls: Exploring putative endophenotypes","volume":"11","author":"E Tenconi","year":"2010","journal-title":"World Journal of Biological Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e20462","DOI":"10.1371\/journal.pone.0020462","article-title":"Cognitive flexibility and clinical severity in eating disorders","volume":"6","author":"K Tchanturia","year":"2011","journal-title":"Plos One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1176\/appi.ajp.162.12.2269","article-title":"Is impaired set-shifting an endophenotype of anorexia nervosa?","volume":"162","author":"J Holliday","year":"2005","journal-title":"Am J Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1017\/S0033291712002188","article-title":"The neuropsychological profile of children at high risk of developing an eating disorder","volume":"43","author":"R Kothari","year":"2013","journal-title":"Psychological Medicine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1176\/appi.ajp.160.2.242","article-title":"Childhood obsessive-compulsive personality traits in adult women with eating disorders: defining a broader eating disorder phenotype","volume":"160","author":"MB Anderluh","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1176\/appi.ajp.2008.08050775","article-title":"Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa","volume":"166","author":"A Zastrow","year":"2009","journal-title":"Am J Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-244X-13-110","article-title":"Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies","volume":"13","author":"OE Titova","year":"2013","journal-title":"Bmc Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1176\/appi.ajp.2007.06111861","article-title":"Gray matter decrease of the anterior cingulate cortex in anorexia nervosa","volume":"164","author":"M Muhlau","year":"2007","journal-title":"Am J Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9582","DOI":"10.1523\/JNEUROSCI.0909-12.2012","article-title":"Dopamine supports coupling of attention-related networks","volume":"32","author":"LC Dang","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuroimage.2010.06.016","article-title":"Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition","volume":"53","author":"RN Spreng","year":"2010","journal-title":"Neuroimage"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e61108","DOI":"10.1371\/journal.pone.0061108","article-title":"Neural Basis of Impaired Cognitive Flexibility in Patients with Anorexia Nervosa","volume":"8","author":"Y Sato","year":"2013","journal-title":"Plos One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/jnnp.2004.039818","article-title":"The cerebral correlates of different types of perseveration in the Wisconsin Card Sorting Test","volume":"76","author":"Y Nagahama","year":"2005","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pneurobio.2008.09.004","article-title":"The cognitive functions of the caudate nucleus","volume":"86","author":"JA Grahn","year":"2008","journal-title":"Prog Neurobiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1176\/appi.ajp.2007.07040575","article-title":"Altered reward processing in women recovered from anorexia nervosa","volume":"164","author":"A Wagner","year":"2007","journal-title":"Am J Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1037\/a0026771","article-title":"Altered implicit category learning in anorexia nervosa","volume":"26","author":"ME Shott","year":"2012","journal-title":"Neuropsychology"},{"key":"ref21","author":"M First","year":"1997"},{"key":"ref22","article-title":"The revised National Adult Reading Test (NART): Test Manual","author":"HE Nelson","year":"1991"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/1098-108X(199412)16:4<363::AID-EAT2260160405>3.0.CO;2-#","article-title":"Assessment of Eating Disorders\u2014Interview or Self-Report Questionnaire","volume":"16","author":"CG Fairburn","year":"1994","journal-title":"International Journal of Eating Disorders"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"AS Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2466\/pr0.1995.76.2.623","article-title":"A New Measure of Cognitive Flexibility","volume":"76","author":"MM Martin","year":"1995","journal-title":"Psychological Reports"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0028-3932(01)00110-5","article-title":"Both random and perseverative errors underlie WCST deficits in prefrontal patients","volume":"40","author":"F Barcelo","year":"2002","journal-title":"Neuropsychologia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1274::AID-MRM27>3.0.CO;2-1","article-title":"Quality control for functional magnetic resonance imaging using automated data analysis and Shewhart charting","volume":"41","author":"A Simmons","year":"1999","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref28","article-title":"SPSS Statistics for Windows, Version 20.0","year":"2011"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/(SICI)1097-0193(1999)7:1<38::AID-HBM4>3.0.CO;2-Q","article-title":"Methods for diagnosis and treatment of stimulus-correlated motion in generic brain activation studies using fMRI","volume":"7","author":"ET Bullmore","year":"1999","journal-title":"Hum Brain Mapp"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1053-8119(03)00077-6","article-title":"Adaptive analysis of fMRI data","volume":"19","author":"O Friman","year":"2003","journal-title":"Neuroimage"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/1097-0193(200102)12:2<61::AID-HBM1004>3.0.CO;2-W","article-title":"Colored noise and computational inference in neurophysiological (fMRI) time series analysis: Resampling methods in time and wavelet domains","volume":"12","author":"E Bullmore","year":"2001","journal-title":"Hum Brain Mapp"},{"key":"ref32","author":"J Talairach","year":"1988"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0730-725X(97)00135-5","article-title":"Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach","volume":"15","author":"MJ Brammer","year":"1997","journal-title":"Magn Reson Imaging"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1109\/42.750253","article-title":"Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain","volume":"18","author":"ET Bullmore","year":"1999","journal-title":"Ieee Transactions on Medical Imaging"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using the false discovery rate","volume":"15","author":"CR Genovese","year":"2002","journal-title":"Neuroimage"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.biopsych.2011.05.028","article-title":"Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa","volume":"70","author":"FA Cowdrey","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1523\/JNEUROSCI.1521-08.2008","article-title":"Lesions of the Medial Striatum in Monkeys Produce Perseverative Impairments during Reversal Learning Similar to Those Produced by Lesions of the Orbitofrontal Cortex","volume":"28","author":"HF Clarke","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"20069","DOI":"10.1073\/pnas.0905314106","article-title":"Precuneus shares intrinsic functional architecture in humans and monkeys","volume":"106","author":"DS Margulies","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/cercor\/bhh189","article-title":"Cognitive control involved in overcoming prepotent response tendencies and switching between tasks","volume":"15","author":"AD Barber","year":"2005","journal-title":"Cerebral Cortex"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.neuropsychologia.2008.06.006","article-title":"Shifting set about task switching: behavioral and neural evidence for distinct forms of cognitive flexibility","volume":"46","author":"SM Ravizza","year":"2008","journal-title":"Neuropsychologia"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/cne.903320204","article-title":"Striatal connections of the parietal association cortices in rhesus monkeys","volume":"332","author":"EH Yeterian","year":"1993","journal-title":"J Comp Neurol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2012.04.010","article-title":"Selective role for striatal and prefrontal regions in processing first trial feedback during single-trial associative learning","volume":"1458","author":"JC Eliassen","year":"2012","journal-title":"Brain Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1162\/jocn_a_00281","article-title":"Intrinsic Architecture Underlying the Relations among the Default, Dorsal Attention, and Frontoparietal Control Networks of the Human Brain","volume":"25","author":"RN Spreng","year":"2013","journal-title":"Journal of Cognitive Neuroscience"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.neuroimage.2005.10.031","article-title":"Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test","volume":"30","author":"CH Lie","year":"2006","journal-title":"Neuroimage"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/01.psy.0000221254.77675.f5","article-title":"Psychiatric comorbidities of female inpatients with eating disorders","volume":"68","author":"BJ Blinder","year":"2006","journal-title":"Psychosom Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T02:07:46Z","timestamp":1651975666000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124027"}},"subtitle":[],"editor":[{"given":"J Bruce","family":"Morton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124027","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}