{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:24:20Z","timestamp":1792081460317,"version":"4.4.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124034","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T14:00:59Z","timestamp":1429711259000},"page":"e0124034","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":158,"title":["Plasma Free Hemoglobin Is an Independent Predictor of Mortality among Patients on Extracorporeal Membrane Oxygenation Support"],"prefix":"10.1371","volume":"10","author":[{"given":"Hesham R.","family":"Omar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mirsaeidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Socias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Sprenker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiano","family":"Caldeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico M.","family":"Camporesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanand","family":"Mangar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"issue":"9698","key":"ref1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0140-6736(09)61069-2","article-title":"Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial","volume":"374","author":"GJ Peek","year":"2009","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/01.MAT.0000151922.67540.E9","article-title":"Extracorporeal Life Support registry report 2004","volume":"51","author":"SA Conrad","year":"2005","journal-title":"ASAIO J"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.athoracsur.2007.05.045","article-title":"Evaluation of outcome scoring systems for patients on extracorporeal membrane oxygenation","volume":"84","author":"CY Lin","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/ndt\/gfl326","article-title":"RIFLE classification is predictive of short-term prognosis in critically ill patients with acute renal failure supported by extracorporeal membrane oxygenation","volume":"21","author":"CY Lin","year":"2006","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.athoracsur.2010.08.063","article-title":"Prognosis of patients on extracorporeal membrane oxygenation: the impact of acute kidney injury on mortality","volume":"91","author":"YC Chen","year":"2011","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jtcvs.2009.10.043","article-title":"Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock","volume":"139","author":"AJ Rastan","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1186\/cc12681","article-title":"Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study","volume":"17","author":"C Aubron","year":"2013","journal-title":"Crit Care"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/ndt\/gfs398","article-title":"Renal function and survival in 200 patients undergoing ECMO therapy","volume":"28","author":"JT Kielstein","year":"2013","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0267659112457969","article-title":"Red blood cell transfusion volume among patients receiving extracorporeal membrane oxygenation","volume":"28","author":"A Smith","year":"2013","journal-title":"Perfusion"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/00002480-200211000-00010","article-title":"Hemolytic characteristics of oxygenators during clinical extracorporeal membrane oxygenation","volume":"48","author":"S Kawahito","year":"2002","journal-title":"ASAIO J"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1097\/PCC.0b013e31823c98ef","article-title":"Hemolytic and thrombocytopathic characteristics of extracorporeal membrane oxygenation systems at simulated flow rate for neonates","volume":"13","author":"AD Meyer","year":"2012","journal-title":"Pediatr Crit Care Med"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0267659110396015","article-title":"Hemolysis and ECMO pumps in the 21st Century","volume":"26","author":"JM Toomasian","year":"2011","journal-title":"Perfusion"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00467-008-1047-z","article-title":"Significance of hemolysis on extracorporeal life support after cardiac surgery in children","volume":"24","author":"R Gbadegesin","year":"2009","journal-title":"Pediatr Nephrol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","article-title":"The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease","volume":"293","author":"RP Rother","year":"2005","journal-title":"J Am Med Assoc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtcvs.2011.02.012","article-title":"Cardiovascular surgery and organ damage: time to reconsider the role of hemolysis","volume":"142","author":"IC Vermeulen Windsant","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/jat\/26.2.67","article-title":"Determination of methemoglobin and total hemoglobin in toxicological studies by derivative spectrophotometry","volume":"26","author":"A Cruz-Landeira","year":"2002","journal-title":"J Anal Toxicol"},{"key":"ref17"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0735-1097(02)02716-X","article-title":"Analysis and results of prolonged resuscitation in cardiac arrest patients rescued by extracorporeal membrane oxygenation","volume":"41","author":"YS Chen","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.resuscitation.2008.05.002","article-title":"Impact of preexisting organ dysfunction on extracorporeal life support for non-postcardiotomy cardiopulmonary failure","volume":"79","author":"MY Wu","year":"2008","journal-title":"Resuscitation"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1051\/ject\/200840257","article-title":"Hemolysis in cardiac surgery patients undergoing cardiopulmonary bypass: a review in search of a treatment algorithm","volume":"40","author":"L Vercaemst","year":"2008","journal-title":"J Extra Corpor Technol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.freeradbiomed.2006.08.017","article-title":"Computation of plasma hemoglobin nitric oxide scavenging in haemolytic anaemias","volume":"41","author":"A Jeffers","year":"2006","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0925-4439(01)00070-9","article-title":"Risk of iron overload is decreased in beating heart coronary artery surgery compared to conventional bypass","volume":"1537","author":"S Mumby","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1681\/ASN.V10112396","article-title":"Acute renal failure after CPB is related to decreased serum ferritin levels","volume":"10","author":"C Davis","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"41","key":"ref24","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.3748\/wjg.v12.i41.6722","article-title":"Hyperbilirubinemia after extracorporeal circulation surgery: a recent and prospective study","volume":"12","author":"Y An","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1525-1594.2007.00392.x","article-title":"Deformability of red blood cells and its relation to blood trauma in rotary blood pumps","volume":"31","author":"N Watanabe","year":"2007","journal-title":"Artif Organs"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1191\/0267659104pf729oa","article-title":"Pump-induced haemolysis: a comparison of short-term ventricular assist devices","volume":"19","author":"M Bennett","year":"2004","journal-title":"Perfusion"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/0267659113509000","article-title":"comparison study of haemolysis production in three contemporary centrifugal pumps","volume":"29","author":"S Bottrell","year":"2014","journal-title":"Perfusion"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/01.PCC.0000163282.63992.13","article-title":"Hemolytic characteristics of three commercially available centrifugal blood pumps","volume":"6","author":"DS Lawson","year":"2005","journal-title":"Pediatr Crit Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T14:17:30Z","timestamp":1691590650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124034"}},"subtitle":[],"editor":[{"given":"Giacomo","family":"Frati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,22]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124034","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,22]]}}}