{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:48:23Z","timestamp":1773211703597,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124087","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T17:49:58Z","timestamp":1429724998000},"page":"e0124087","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Pathogenesis of Human Cervical Epithelium Cells Induced by Interacting with Trichomonas vaginalis"],"prefix":"10.1371","volume":"10","author":[{"given":"Wei-Chen","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ting","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuey-Yu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Wei","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"issue":"4","key":"ref1","first-page":"794","article-title":"Trichomoniasis. Clinical microbiology reviews","volume":"17","author":"JR Schwebke","year":"2004","journal-title":"Trichomoniasis. Clinical microbiology reviews"},{"issue":"4","key":"ref2","first-page":"352","article-title":"Innate immunity and allergic diseases","volume":"51","author":"S Akira","year":"2002","journal-title":"Arerugi = [Allergy]"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1017\/S0950268804003127","article-title":"Seroepidemiology of Trichomonas vaginalis in rural women in Zimbabwe and patterns of association with HIV infection","volume":"133","author":"PR Mason","year":"2005","journal-title":"Epidemiology and infection"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/OLQ.0b013e3181cfcc4b","article-title":"Epidemiological synergy of Trichomonas vaginalis and HIV in Zimbabwean and South African women","volume":"37","author":"SN Mavedzenge","year":"2010","journal-title":"Sexually transmitted diseases"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1086\/511278","article-title":"Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition","volume":"195","author":"RS McClelland","year":"2007","journal-title":"The Journal of infectious diseases"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1086\/526496","article-title":"Trichomonas vaginalis infection and human immunodeficiency virus acquisition in African women","volume":"197","author":"B Van Der Pol","year":"2008","journal-title":"The Journal of infectious diseases"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/IAI.50.3.778-786.1985","article-title":"Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis","volume":"50","author":"JN Krieger","year":"1985","journal-title":"Infection and immunity"},{"issue":"1","key":"ref8","first-page":"35","article-title":"Contact-independent cytotoxicity of Trichomonas vaginalis","volume":"69","author":"FF Pindak","year":"1993","journal-title":"Genitourinary medicine"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/mpat.1996.0010","article-title":"Trichomonas vaginalis haemolysis: pH regulates a contact-independent mechanism based on pore-forming proteins","volume":"20","author":"PL Fiori","year":"1996","journal-title":"Microbial pathogenesis"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1128\/IAI.65.12.5142-5148.1997","article-title":"Contact-dependent disruption of the host cell membrane skeleton induced by Trichomonas vaginalis","volume":"65","author":"PL Fiori","year":"1997","journal-title":"Infection and immunity"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1128\/IAI.01244-12","article-title":"Trichomonas vaginalis contact-dependent cytolysis of epithelial cells","volume":"81","author":"G Lustig","year":"2013","journal-title":"Infection and immunity"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2958.1992.tb01536.x","article-title":"Molecular basis of host epithelial cell recognition by Trichomonas vaginalis","volume":"6","author":"R Arroyo","year":"1992","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/mpat.1999.0336","article-title":"A novel cysteine proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity","volume":"28","author":"ME Alvarez-Sanchez","year":"2000","journal-title":"Microbial pathogenesis"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1128\/IAI.73.10.6472-6478.2005","article-title":"Adherence to human vaginal epithelial cells signals for increased expression of Trichomonas vaginalis genes","volume":"73","author":"AS Kucknoor","year":"2005","journal-title":"Infection and immunity"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2199-6-5","article-title":"Heterologous expression in Tritrichomonas foetus of functional Trichomonas vaginalis AP65 adhesin","volume":"6","author":"AS Kucknoor","year":"2005","journal-title":"BMC molecular biology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2180-7-116","article-title":"Characterization of the Trichomonas vaginalis surface-associated AP65 and binding domain interacting with trichomonads and host cells","volume":"7","author":"AF Garcia","year":"2007","journal-title":"BMC microbiology"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1111\/j.1462-5822.2007.00979.x","article-title":"The proteins secreted by Trichomonas vaginalis and vaginal epithelial cell response to secreted and episomally expressed AP65","volume":"9","author":"AS Kucknoor","year":"2007","journal-title":"Cellular microbiology"},{"issue":"Pt 10","key":"ref18","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1099\/00221287-145-10-2835","article-title":"Trichomonas vaginalis interactions with fibronectin and laminin","volume":"145","author":"ML Crouch","year":"1999","journal-title":"Microbiology"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/expr.1998.4227","article-title":"YIGSR is the preferential laminin-1 residing adhesion sequence for Trichomonas vaginalis","volume":"88","author":"FC Silva Filho","year":"1998","journal-title":"Experimental parasitology"},{"issue":"1","key":"ref20","first-page":"39","article-title":"Fibronectin- and laminin-mediated endocytic activity in the parasitic protozoa Trichomonas vaginalis and Tritrichomonas foetus","volume":"22","author":"M Benchimol","year":"1990","journal-title":"Journal of submicroscopic cytology and pathology"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1111\/j.1462-5822.2008.01190.x","article-title":"Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis","volume":"10","author":"CY Okumura","year":"2008","journal-title":"Cellular microbiology"},{"issue":"2","key":"ref22","first-page":"106","article-title":"Behaviour and pathogenicity of Trichomonas vaginalis in epithelial cell cultures: a study by light and scanning electron microscopy","volume":"57","author":"JP Heath","year":"1981","journal-title":"The British journal of venereal diseases"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1128\/IAI.72.3.1326-1332.2004","article-title":"Production of interleukin-8 by human neutrophils stimulated with Trichomonas vaginalis","volume":"72","author":"JS Ryu","year":"2004","journal-title":"Infection and immunity"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3347\/kjp.2011.49.3.291","article-title":"NF-kappaB and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products","volume":"49","author":"YH Nam","year":"2011","journal-title":"The Korean journal of parasitology"},{"issue":"14\u201315","key":"ref25","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.micinf.2011.07.006","article-title":"Leukotriene B4 receptor BLT-mediated phosphorylation of NF-kappaB and CREB is involved in IL-8 production in human mast cells induced by Trichomonas vaginalis-derived secretory products","volume":"13","author":"YH Nam","year":"2011","journal-title":"Microbes and infection \/ Institut Pasteur"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-3024.1995.tb01014.x","article-title":"Influence of humoral immunity on leukotriene B4 production by neutrophils in response to Trichomonas vaginalis stimulation","volume":"17","author":"MF Shaio","year":"1995","journal-title":"Parasite immunology"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1128\/IAI.60.11.4475-4482.1992","article-title":"A novel neutrophil-activating factor released by Trichomonas vaginalis","volume":"60","author":"MF Shaio","year":"1992","journal-title":"Infection and immunity"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1550-7408.1995.tb01579.x","article-title":"YI-S, a casein-free medium for axenic cultivation of Entamoeba histolytica, related Entamoeba, Giardia intestinalis and Trichomonas vaginalis","volume":"42","author":"LS Diamond","year":"1995","journal-title":"The Journal of eukaryotic microbiology"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ygeno.2009.01.004","article-title":"Identification of microRNA in the protist Trichomonas vaginalis","volume":"93","author":"WC Lin","year":"2009","journal-title":"Genomics"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1128\/JCM.36.11.3205-3210.1998","article-title":"Diagnosis of Trichomonas vaginalis infection by PCR using vaginal swab samples","volume":"36","author":"G Madico","year":"1998","journal-title":"Journal of clinical microbiology"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1128\/EC.5.2.391-399.2006","article-title":"Multifarious transcriptional regulation of adhesion protein gene ap65-1 by a novel Myb1 protein in the protozoan parasite Trichomonas vaginalis","volume":"5","author":"SJ Ong","year":"2006","journal-title":"Eukaryotic cell"},{"issue":"5809","key":"ref32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.1132894","article-title":"Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis","volume":"315","author":"JM Carlton","year":"2007","journal-title":"Science"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0736-4679(94)00112-X","article-title":"Neonatal Trichomonas vaginalis infection","volume":"13","author":"IS Danesh","year":"1995","journal-title":"The Journal of emergency medicine"},{"issue":"33","key":"ref34","first-page":"1821","article-title":"Neonatal respiratory insufficiency caused by maternal infection with trichomonas vaginalis","volume":"141","author":"A Kerekes","year":"2000","journal-title":"Orvosi hetilap"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1258\/ijsa.2010.010174","article-title":"Neonatal Trichomonas vaginalis infection: a case report and review of literature","volume":"21","author":"J Trintis","year":"2010","journal-title":"International journal of STD & AIDS"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1128\/IAI.00631-06","article-title":"Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells","volume":"74","author":"RN Fichorova","year":"2006","journal-title":"Infection and immunity"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1462-5822.2005.00522.x","article-title":"Trichomonas vaginalis adherence mediates differential gene expression in human vaginal epithelial cells","volume":"7","author":"A Kucknoor","year":"2005","journal-title":"Cellular microbiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1749-6632.2009.04025.x","article-title":"Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions","volume":"1165","author":"S Koch","year":"2009","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1128\/IAI.73.7.4155-4160.2005","article-title":"Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1","volume":"73","author":"PC Guenthner","year":"2005","journal-title":"Infection and immunity"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/infdis\/170.6.1638","article-title":"Monocyte-derived interleukin-8 involved in the recruitment of neutrophils induced by Trichomonas vaginalis infection","volume":"170","author":"MF Shaio","year":"1994","journal-title":"The Journal of infectious diseases"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/IAI.63.10.3864-3870.1995","article-title":"Generation of interleukin-8 from human monocytes in response to Trichomonas vaginalis stimulation","volume":"63","author":"MF Shaio","year":"1995","journal-title":"Infection and immunity"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"e1003482","DOI":"10.1371\/journal.ppat.1003482","article-title":"Trichomonas vaginalis exosomes deliver cargo to host cells and mediate hostratioparasite interactions","volume":"9","author":"O Twu","year":"2013","journal-title":"PLoS pathogens"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1172\/JCI118161","article-title":"Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha","volume":"96","author":"L Eckmann","year":"1995","journal-title":"The Journal of clinical investigation"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1beta causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"RM Al-Sadi","year":"2007","journal-title":"Journal of immunology"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/j.gastro.2003.10.067","article-title":"Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon","volume":"126","author":"JC Hardwick","year":"2004","journal-title":"Gastroenterology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T20:48:59Z","timestamp":1651783739000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124087"}},"subtitle":[],"editor":[{"given":"Xuefeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,22]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124087","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,22]]}}}