{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:36:47Z","timestamp":1767706607390},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124301","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T19:18:42Z","timestamp":1429125522000},"page":"e0124301","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Attenuation of Progressive Hearing Loss in DBA\/2J Mice by Reagents that Affect Epigenetic Modifications Is Associated with Up-Regulation of the Zinc Importer Zip4"],"prefix":"10.1371","volume":"10","author":[{"given":"Hideki","family":"Mutai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyuki","family":"Miya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000106478","article-title":"The complexity of age-related hearing impairment: contributing environmental and genetic factors","volume":"12","author":"E Van Eyken","year":"2007","journal-title":"Audiol Neurootol"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Fujimoto C, Yamasoba T. Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss. Oxid Med Cell Longev. 2014: 582849.","DOI":"10.1155\/2014\/582849"},{"key":"ref3","first-page":"116","article-title":"Zinc and presbycusis","volume":"6","author":"GE Shambaugh Jr","year":"1985","journal-title":"Am J Otol"},{"key":"ref4","first-page":"156","article-title":"Zinc: the neglected nutrient","volume":"10","author":"GE Shambaugh Jr","year":"1989","journal-title":"Am J Otol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/WNR.0b013e328350235f","article-title":"Effects of a zinc-deficient diet on hearing in CBA mice","volume":"23","author":"WS Kang","year":"2012","journal-title":"Neuroreport"},{"key":"ref6","first-page":"915","article-title":"The serum zinc level in patients with tinnitus and the effect of zinc treatment","volume":"100","author":"K Ochi","year":"1997","journal-title":"Otolaryngol Jpn"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.amjoto.2014.11.001","article-title":"Effects of serum zinc level on tinnitus","volume":"36","author":"G Berkiten","year":"2015","journal-title":"Am J Otolaryngol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF00464266","article-title":"A clinical correlation between hypozincemia and tinnitus","volume":"244","author":"M Gersdorff","year":"1987","journal-title":"Arch Otorhinolaryngol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1177\/000348949110000809","article-title":"Zinc in the management of tinnitus. Placebo-controlled trial","volume":"100","author":"PB Paaske","year":"1991","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/lary.21291","article-title":"Zinc in the treatment of idiopathic sudden sensorineural hearing loss","volume":"121","author":"CH Yang","year":"2011","journal-title":"Laryngoscope"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"679S","DOI":"10.3945\/ajcn.110.005744","article-title":"Zinc: an essential but elusive nutrient","volume":"94","author":"JC King","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.mam.2012.05.011","article-title":"The SLC39 family of zinc transporters","volume":"34","author":"J Jeong","year":"2013","journal-title":"Mol Aspects Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.mam.2012.05.008","article-title":"The SLC30 family of zinc transporters\u2014a review of current understanding of their biological and pathophysiological roles","volume":"34","author":"L Huang","year":"2013","journal-title":"Mol Aspects Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/hmg\/ddm088","article-title":"The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency","volume":"16","author":"J Dufner-Beattie","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jnutbio.2009.12.009","article-title":"Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells","volume":"22","author":"IM Quesada","year":"2011","journal-title":"J Nutr Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ajcn\/69.3.564","article-title":"Age-related hearing loss, vitamin B-12, and folate in elderly women","volume":"69","author":"DK Houston","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.otohns.2010.08.031","article-title":"Age-related hearing loss, vitamin B12, and folate in the elderly","volume":"143","author":"AO Lasisi","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2217\/epi.10.44","article-title":"Molecular coupling of DNA methylation and histone methylation","volume":"2","author":"H Hashimoto","year":"2010","journal-title":"Epigenomics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1101\/lm.026575.112","article-title":"Epigenetic regulation of memory formation and maintenance","volume":"20","author":"IB Zovkic","year":"2013","journal-title":"Learn Mem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2007.07.002","article-title":"A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns","volume":"233","author":"MJ Provenzano","year":"2007","journal-title":"Hear Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/dneu.20746","article-title":"Expression of Pou3f3\/Brn-1 and its genomic methylation in developing auditory epithelium","volume":"69","author":"H Mutai","year":"2009","journal-title":"Dev Neurobiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e36066","DOI":"10.1371\/journal.pone.0036066","article-title":"Stemness of the organ of corti relates to the epigenetic status of sox2 enhancers","volume":"7","author":"J Waldhaus","year":"2012","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ng1262","article-title":"Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy","volume":"35","author":"PG van Overveld","year":"2003","journal-title":"Nat Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ng.830","article-title":"Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss","volume":"43","author":"CJ Klein","year":"2011","journal-title":"Nat Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-0042-1748517","article-title":"Otoacoustic emission findings in Rett syndrome","volume":"10","author":"S Nicholas","year":"1999","journal-title":"J Am Acad Audiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/00206090009073057","article-title":"Auditory brainstem responses in Rett syndrome: effects of hyperventilation, seizures, and tympanometric variables","volume":"39","author":"JP Pillion","year":"2000","journal-title":"Audiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1093\/hmg\/ddu002","article-title":"Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance","volume":"23","author":"FJ Kaiser","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"K Noben-Trauth","year":"2003","journal-title":"Nat Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.1541-10.2010","article-title":"The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA\/2J mice","volume":"30","author":"JB Shin","year":"2010","journal-title":"J Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(98)00029-X","article-title":"Genetics of age-related hearing loss in mice. IV. Cochlear pathology and hearing loss in 25 BXD recombinant inbred mouse strains","volume":"119","author":"JF Willott","year":"1998","journal-title":"Hear Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1254\/jphs.11227FP","article-title":"A novel animal model of hearing loss caused by acute endoplasmic reticulum stress in the cochlea","volume":"118","author":"Y Fujinami","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"BM Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J Roy Statist Soc Ser B"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"33474","DOI":"10.1074\/jbc.M305000200","article-title":"The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice","volume":"278","author":"J Dufner-Beattie","year":"2003","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/00016486509124579","article-title":"Development of hearing in the normal CBA-J mouse: Correlation of Physiological Observations with Behavioral Responses and with Cochlear Anatomy","volume":"59","author":"D Mikaelian","year":"1965","journal-title":"Acta Oto-Laryngologica"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1073\/pnas.262658999","article-title":"An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability","volume":"99","author":"L Tremolizzo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopsych.2004.11.046","article-title":"Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice","volume":"57","author":"L Tremolizzo","year":"2005","journal-title":"Biol Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1242\/dev.126.11.2335","article-title":"Otx1 and Otx2 activities are required for the normal development of the mouse inner ear","volume":"126","author":"H Morsli","year":"1999","journal-title":"Development"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF03654841","article-title":"Age related changes in gene expression within the cochlea of C57BL\/6J mice","volume":"24","author":"RJ Marano","year":"2012","journal-title":"Aging Clin Exp Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2008.03.031","article-title":"Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone","volume":"1212","author":"T Mikuriya","year":"2008","journal-title":"Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1080\/00016480600702118","article-title":"Gene expression changes during step-wise differentiation of embryonic stem cells along the inner ear hair cell pathway","volume":"126","author":"MG De Silva","year":"2006","journal-title":"Acta Otolaryngol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jneumeth.2008.02.022","article-title":"Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice","volume":"171","author":"M D'Souza","year":"2008","journal-title":"J Neurosci Methods"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"13748","DOI":"10.1016\/S0021-9258(17)36709-1","article-title":"DNA polymerase delta is involved in the cellular response to UV damage in human cells","volume":"269","author":"XR Zeng","year":"1994","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.neuroscience.2009.07.059","article-title":"Mitotic activity and specification of fibrocyte subtypes in the developing rat cochlear lateral wall","volume":"163","author":"H Mutai","year":"2009","journal-title":"Neuroscience"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3109\/00016489609137935","article-title":"Localization of Cu\/Zn-SOD and Mn-SOD in the rat cochlea","volume":"116","author":"KE Rarey","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/00016489409126037","article-title":"Immunolocalization of Na+, K(+)-ATPase, Ca(++)-ATPase, calcium-binding proteins, and carbonic anhydrase in the guinea pig inner ear","volume":"114","author":"I Ichimiya","year":"1994","journal-title":"Acta Otolaryngol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00176533","article-title":"Hearing loss related to zinc deficiency in rats","volume":"247","author":"LJ Hoeve","year":"1990","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2007.08.090","article-title":"Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA\/2J mice","volume":"1182","author":"S Someya","year":"2007","journal-title":"Brain Res"},{"key":"ref49","first-page":"731","article-title":"<sc>l<\/sc>- and <sc>d<\/sc>-methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity","volume":"20","author":"D Reser","year":"1999","journal-title":"Neurotoxicology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1471-4159.2009.05871.x","article-title":"Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea","volume":"108","author":"FQ Chen","year":"2009","journal-title":"J Neurochem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/01.mlg.0000197630.85208.36","article-title":"The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs","volume":"116","author":"M Drottar","year":"2006","journal-title":"Laryngoscope"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-146-1-200701020-00003","article-title":"Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial","volume":"146","author":"J Durga","year":"2007","journal-title":"Ann Intern Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications","volume":"82","author":"BN Singh","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijdevneu.2007.12.003","article-title":"Attenuation of senescence-induced oxidative exacerbations in aged rat brain by (-)-epigallocatechin-3-gallate","volume":"26","author":"R Srividhya","year":"2008","journal-title":"Int J Dev Neurosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.0908786106","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"106","author":"S Someya","year":"2009","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T12:08:15Z","timestamp":1717848495000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124301"}},"subtitle":[],"editor":[{"given":"Berta","family":"Alsina","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,14]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124301","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,14]]}}}