{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:57:26Z","timestamp":1778853446400,"version":"3.51.4"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124368","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T18:39:00Z","timestamp":1429123140000},"page":"e0124368","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Sintered Indium-Tin Oxide Particles Induce Pro-Inflammatory Responses In Vitro, in Part through Inflammasome Activation"],"prefix":"10.1371","volume":"10","author":[{"given":"Melissa A.","family":"Badding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Schwegler-Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Hyeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie R.","family":"Fix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin J.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen S.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,4,13]]},"reference":[{"issue":"1\u20132","key":"ref1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0167-577X(01)00377-9","article-title":"Rapid rate sintering of nanocrystalline indium tin oxide ceramics: Particle size effect","volume":"52","author":"B-C Kim","year":"2002","journal-title":"Mater Lett"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1151-2916.2001.tb00645.x","article-title":"Fabrication of low-porosity indium tin oxide ceramics in air from hydrothermally prepared powder","volume":"84","author":"CP Udawatte","year":"2001","journal-title":"J Am Ceramic Soc"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1539\/joh.45.137","article-title":"Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide","volume":"45","author":"T Homma","year":"2003","journal-title":"J Occup Health"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1183\/09031936.00020306","article-title":"Interstitial pulmonary disorders in indium-processing workers","volume":"29","author":"T Chonan","year":"2007","journal-title":"Eur Respir J"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/oem.2006.029124","article-title":"Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage","volume":"65","author":"T Hamaguchi","year":"2008","journal-title":"Occup Environ Med"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1539\/joh.L9077","article-title":"Causal relationship between indium compound inhalation and effects on the lungs","volume":"51","author":"M Nakano","year":"2009","journal-title":"J Occup Health"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ajim.22125","article-title":"Serial evaluations at an indium-tin oxide production facility","volume":"56","author":"KJ Cummings","year":"2013","journal-title":"Am J Ind Med"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1378\/chest.11-1880","article-title":"Indium lung disease","volume":"141","author":"KJ Cummings","year":"2012","journal-title":"Chest"},{"issue":"20","key":"ref9","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/15287394.2014.920757","article-title":"Cytotoxicity and characterization of particles collected from an indium\u2013tin oxide production facility","volume":"77","author":"MA Badding","year":"2014","journal-title":"J Toxicol Environ Health A"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/toxsci\/kfp014","article-title":"Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity","volume":"108","author":"D Lison","year":"2009","journal-title":"Toxicol Sci"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/toxsci\/kft154","article-title":"Macrophage solubilization and cytotoxicity of indium-containing particles in vitro","volume":"135","author":"WM Gwinn","year":"2013","journal-title":"Toxicol Sci"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1539\/joh.L10128","article-title":"Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats","volume":"53","author":"K Nagano","year":"2011","journal-title":"J Occup Health"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1539\/joh.10-0053-BR","article-title":"Pulmonary toxicity in mice by 2- and 13-week inhalation exposures to indium-tin oxide and indium oxide aerosols","volume":"53","author":"K Nagano","year":"2011","journal-title":"J Occup Health"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1539\/joh.L9097","article-title":"Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters","volume":"52","author":"A Tanaka","year":"2010","journal-title":"J Occup Health"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/105707","article-title":"Potential role of the inflammasome-derived inflammatory cytokines in pulmonary fibrosis","volume":"2011","author":"R Biswas","year":"2011","journal-title":"Pulm Med"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"L Franchi","year":"2009","journal-title":"Nat Immunol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1164\/rccm.201003-0359OC","article-title":"Extracellular ATP is a Danger signal activating P2X7 receptor in lung inflammation and fibrosis","volume":"182","author":"N Riteau","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"7293","key":"ref18","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"P Duewell","year":"2010","journal-title":"Nature"},{"issue":"7081","key":"ref19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"F Martinon","year":"2006","journal-title":"Nature"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-\u03b2","volume":"9","author":"A Halle","year":"2008","journal-title":"Nat Immunol"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"V Hornung","year":"2008","journal-title":"Nat Immunol"},{"issue":"26","key":"ref22","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1073\/pnas.0803933105","article-title":"The Nalp3 inflammasome is essential for the development of silicosis","volume":"105","author":"SL Cassel","year":"2008","journal-title":"PNAS"},{"issue":"5876","key":"ref23","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"C Dostert","year":"2008","journal-title":"Science"},{"key":"ref24","unstructured":"National Institute for Occupational Safety and Health (NIOSH). 2012. Hazard evaluation and technical assistance report: An evaluation of preventive measures at an indium-tin oxide production facility. Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention. Publication No. HETA 2009-0214-3153."},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-8977-9-32","article-title":"Comparison of non-crystalline silica nanoparticles in IL-1beta release from macrophages","volume":"9","author":"W Sandberg","year":"2012","journal-title":"Part Fibre Toxicol"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2672.2009.04433.x","article-title":"Metalworking fluids biodiversity characterization","volume":"108","author":"Y Gilbert","year":"2010","journal-title":"J Appl Microbiol"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0013-9351(05)80081-7","article-title":"Environmental endotoxin measurement: the kinetic <italic>Limulus<\/italic> assay with resistant-parallel-line estimation","volume":"57","author":"DK Milton","year":"1992","journal-title":"Environ Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-8977-7-32","article-title":"Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species","volume":"7","author":"SS Leonard","year":"2010","journal-title":"Part Fibre Toxicol"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"e101310","DOI":"10.1371\/journal.pone.0101310","article-title":"A comparison of cytotoxicity and oxidative stress from welding fumes generated with a new nickel-, copper-based consumable versus mild and stainless steel-based welding in RAW 264.7 mouse macrophages","volume":"9","author":"MA Badding","year":"2014","journal-title":"PLoS ONE"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.coi.2009.12.004","article-title":"The inflammasomes: mechanisms of activation and function","volume":"22","author":"E Latz","year":"2010","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200903124","article-title":"Glyburide inhibits the Cryopyrin\/Nalp3 inflammasome","volume":"187","author":"M Lamkanfi","year":"2009","journal-title":"J Cell Biol"},{"issue":"6372","key":"ref32","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1\u03b2 processing in monocytes","volume":"356","author":"NA Thornberry","year":"1992","journal-title":"Nature"},{"issue":"21","key":"ref33","doi-asserted-by":"crossref","first-page":"15195","DOI":"10.1016\/S0021-9258(17)36591-2","article-title":"Interleukin-1 beta maturation and release in response to ATP and nigericin: Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity","volume":"269","author":"D Perregaux","year":"1994","journal-title":"J Biol Chem"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"V Petrilli","year":"2007","journal-title":"Cell Death Differ"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1539\/joh.11-0233-OA","article-title":"Assessment of workplace air concentrations of indium dust in an indium-recycling plant","volume":"54","author":"H Miyauchi","year":"2012","journal-title":"J Occup Health"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1164\/rccm.200907-1022CR","article-title":"Pulmonary alveolar proteinosis in workers at an indium processing facility","volume":"181","author":"KJ Cummings","year":"2010","journal-title":"Am J Resp Crit Care Med"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-\u03baB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"FG Bauernfeind","year":"2009","journal-title":"J Immunol"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"e6510","DOI":"10.1371\/journal.pone.0006510","article-title":"Malarial hemozoin is a Nalp3 inflammasome activating danger signal","volume":"4","author":"C Dostert","year":"2009","journal-title":"PLoS ONE"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4049\/jimmunol.1202737","article-title":"TLR agonists stimulate nlrp3-dependent IL-1\u03b2 production independently of the purinergic P2X7 receptor in dendritic cells and in vivo","volume":"190","author":"Y He","year":"2013","journal-title":"J Immunol"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1\u03b2 in monocytes and macrophages","volume":"113","author":"MG Netea","year":"2009","journal-title":"Blood"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The inflammasome NLRs in immunity, inflammation, and associated diseases","volume":"29","author":"BK Davis","year":"2011","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1021\/nn200595c","article-title":"Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism","volume":"5","author":"J Palom\u00e4ki","year":"2011","journal-title":"ACS Nano"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.nano.2011.11.004","article-title":"Double-walled carbon nanotubes trigger IL-1\u03b2 release in human monocytes through Nlrp3 inflammasome activation","volume":"8","author":"E Meunier","year":"2012","journal-title":"Nanomed-Nanotechnol"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jor.20826","article-title":"Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity","volume":"27","author":"MS Caicedo","year":"2009","journal-title":"J Orthop Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T04:18:15Z","timestamp":1651724295000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124368"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,13]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124368","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,13]]}}}