{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:43:15Z","timestamp":1792194195862,"version":"4.4.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124450","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T13:57:21Z","timestamp":1429711041000},"page":"e0124450","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Epididymal Region-Specific miRNA Expression and DNA Methylation and Their Roles in Controlling Gene Expression in Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"Chen","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanggang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengsong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wubin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1126\/science.1056545","article-title":"An antimicrobial peptide gene found in the male reproductive system of rats","volume":"291","author":"P Li","year":"2001","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e4106","DOI":"10.1371\/journal.pone.0004106","article-title":"An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility","volume":"3","author":"Y Zhou","year":"2008","journal-title":"PLoS One"},{"key":"ref3","first-page":"2074","article-title":"Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice","volume":"119","author":"E Chabory","year":"2009","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00018-010-0478-4","article-title":"The epididymis-specific antimicrobial peptide beta-defensin 15 is required for sperm motility and male fertility in the rat (Rattus norvegicus)","volume":"68","author":"Y Zhao","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1095\/biolreprod65.3.696","article-title":"Dynamic changes in gene expression along the rat epididymis","volume":"65","author":"KM Jervis","year":"2001","journal-title":"Biol Reprod"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1095\/biolreprod.103.021493","article-title":"DNA microarray analysis of region-specific gene expression in the mouse epididymis","volume":"70","author":"N Hsia","year":"2004","journal-title":"Biology of Reproduction"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1095\/biolreprod.103.026302","article-title":"Androgen-regulated genes in the murine epididymis","volume":"71","author":"TR Chauvin","year":"2004","journal-title":"Biol Reprod"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1210\/me.2010-0226","article-title":"Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis","volume":"24","author":"S Hu","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2164\/jandrol.111.014266","article-title":"Androgen action in the epididymis","volume":"32","author":"B Robaire","year":"2011","journal-title":"J Androl"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"A Bird","year":"2002","journal-title":"Genes Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"AM Deaton","year":"2011","journal-title":"Genes Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"DP Bartel","year":"2009","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.compbiomed.2013.12.007","article-title":"miRClassify: an advanced web server for miRNA family classification and annotation","volume":"45","author":"Q Zou","year":"2014","journal-title":"Comput Biol Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.4161\/cc.9.19.13385","article-title":"DNA methylation and epigenetic control of cellular differentiation","volume":"9","author":"DA Khavari","year":"2010","journal-title":"Cell Cycle"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1371\/journal.pbio.0060022","article-title":"A novel CpG island set identifies tissue-specific methylation at developmental gene loci","volume":"6","author":"R Illingworth","year":"2008","journal-title":"PLoS Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.stem.2010.06.012","article-title":"MicroRNAs as regulators of differentiation and cell fate decisions","volume":"7","author":"KN Ivey","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1096\/fj.09-152207","article-title":"miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells","volume":"24","author":"C Tarantino","year":"2010","journal-title":"FASEB J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature02625","article-title":"Epigenetics in human disease and prospects for epigenetic therapy","volume":"429","author":"G Egger","year":"2004","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1003250","DOI":"10.1371\/journal.pgen.1003250","article-title":"DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer","volume":"9","author":"C Grimm","year":"2013","journal-title":"PLoS Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"R214","DOI":"10.1186\/gb-2007-8-10-r214","article-title":"MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype","volume":"8","author":"C Blenkiron","year":"2007","journal-title":"Genome Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1210\/me.2011-1059","article-title":"DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis","volume":"26","author":"A Bhardwaj","year":"2012","journal-title":"Mol Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/abbs\/gmp116","article-title":"Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides","volume":"42","author":"J Zhang","year":"2010","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e38457","DOI":"10.1371\/journal.pone.0038457","article-title":"Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling","volume":"7","author":"I Bjorkgren","year":"2012","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1074\/jbc.M111.303636","article-title":"MicroRNA-29a Inhibited Epididymal Epithelial Cell Proliferation by Targeting Nuclear Autoantigenic Sperm Protein (NASP)","volume":"287","author":"W Ma","year":"2012","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/abbs\/gmr122","article-title":"MiR-200a is involved in rat epididymal development by targeting beta-catenin mRNA","volume":"44","author":"X Wu","year":"2012","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/abbs\/gmq073","article-title":"miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats","volume":"42","author":"J Wang","year":"2010","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbrc.2010.10.002","article-title":"miR-335 is involved in the rat epididymal development by targeting the mRNA of RASA1","volume":"402","author":"J Wang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1095\/biolreprod.113.110486","article-title":"Epididymosomes convey different repertoires of microRNAs throughout the bovine epididymis","volume":"89","author":"C Belleannee","year":"2013","journal-title":"Biol Reprod"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e34996","DOI":"10.1371\/journal.pone.0034996","article-title":"Role of microRNAs in controlling gene expression in different segments of the human epididymis","volume":"7","author":"C Belleannee","year":"2012","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1095\/biolreprod.106.057323","article-title":"The rat epididymal transcriptome: comparison of segmental gene expression in the rat and mouse epididymides","volume":"76","author":"SA Jelinsky","year":"2007","journal-title":"Biology of Reproduction"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1182\/blood-2014-04-566760","article-title":"Gray platelet syndrome: proinflammatory megakaryocytes and alpha-granule loss cause myelofibrosis and confer metastasis resistance in mice","volume":"124","author":"JA Guerrero","year":"2014","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"17266","DOI":"10.1073\/pnas.1419599111","article-title":"Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy","volume":"111","author":"S Zhang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0076-6879(06)11014-9","article-title":"Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays","volume":"411","author":"PC Scacheri","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk\u2014database: prediction of possible miRNA binding sites by &quot;walking&quot; the genes of three genomes","volume":"44","author":"H Dweep","year":"2011","journal-title":"J Biomed Inform"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"Suppl 14","key":"ref38","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2105-12-S14-S6","article-title":"iGepros: an integrated gene and protein annotation server for biological nature exploration","volume":"12","author":"G Zheng","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1","volume":"10","author":"PA Gregory","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1210\/en.2010-0023","article-title":"Identification of early response genes and pathway activated by androgens in the initial segment and caput regions of the regressed rat epididymis","volume":"151","author":"M Hamzeh","year":"2010","journal-title":"Endocrinology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1261\/rna.7240905","article-title":"Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes","volume":"11","author":"S Baskerville","year":"2005","journal-title":"RNA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4161\/epi.6.6.16196","article-title":"Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome","volume":"6","author":"J Sandoval","year":"2011","journal-title":"Epigenetics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1101\/gad.1640608","article-title":"The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2","volume":"22","author":"SM Park","year":"2008","journal-title":"Genes Dev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/embor.2008.74","article-title":"A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells","volume":"9","author":"U Burk","year":"2008","journal-title":"EMBO Rep"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.canlet.2013.11.004","article-title":"MiR-200, a new star miRNA in human cancer","volume":"344","author":"X Feng","year":"2014","journal-title":"Cancer Lett"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","article-title":"The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2","volume":"283","author":"M Korpal","year":"2008","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1172\/JCI39191","article-title":"Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice","volume":"120","author":"CP Corpe","year":"2010","journal-title":"J Clin Invest"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1242\/jcs.01560","article-title":"A role for the small GTPase Rab21 in the early endocytic pathway","volume":"117","author":"JC Simpson","year":"2004","journal-title":"J Cell Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.200509019","article-title":"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins","volume":"173","author":"T Pellinen","year":"2006","journal-title":"J Cell Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/366362a0","article-title":"Role for DNA methylation in genomic imprinting","volume":"366","author":"E Li","year":"1993","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1043-2760(00)00248-4","article-title":"DNA methylation and silencing of gene expression","volume":"11","author":"J Newell-Price","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrg3354","article-title":"DNA methylation: roles in mammalian development","volume":"14","author":"ZD Smith","year":"2013","journal-title":"Nat Rev Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:39:20Z","timestamp":1540309160000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124450"}},"subtitle":[],"editor":[{"given":"Jo\u00ebl R","family":"Drevet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,22]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124450","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,22]]}}}