{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T21:10:15Z","timestamp":1717881015863},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124559","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T17:45:23Z","timestamp":1430847923000},"page":"e0124559","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["IL10 Variant g.5311A Is Associated with Visceral Leishmaniasis in Indian Population"],"prefix":"10.1371","volume":"10","author":[{"given":"Anshuman","family":"Mishra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh","family":"Nizamuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geethika","family":"Arekatla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satya","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemlata","family":"Dewangan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abishai","family":"Dominic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Digumarthi V. S.","family":"Sudhakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narasimha R.","family":"Parine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin C.","family":"Tupperwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumarasamy","family":"Thangaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"issue":"7","key":"ref1","first-page":"195","article-title":"Diagnosis and treatment of Indian visceral leishmaniasis","volume":"51","author":"S Sundar","year":"2003","journal-title":"J Assoc Physicians India"},{"issue":"5","key":"ref2","first-page":"417","article-title":"Leishmaniasis. Public health aspects and control","volume":"14","author":"P Desjeux","year":"1996","journal-title":"Clin Dermatol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"e2053","DOI":"10.1371\/journal.pntd.0002053","article-title":"Latent infection with Leishmania donovani in highly endemic villages in Bihar, India","volume":"7","author":"E Hasker","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"e859","DOI":"10.1371\/journal.pntd.0000859","article-title":"Insecticide susceptibility of Phlebotomus argentipes in visceral leishmaniasis endemic districts in India and Nepal","volume":"4","author":"DS Dinesh","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1086\/382077","article-title":"Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project","volume":"38","author":"PJ Hotez","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0035-9203(00)90255-4","article-title":"Socio-economics of visceral leishmaniasis in Bihar (India)","volume":"94","author":"CP Thakur","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"ref7","first-page":"62","article-title":"Epidemiology of visceral leishmaniasis in India","volume":"12","author":"D Bora","year":"1999","journal-title":"Natl Med J India"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ng.2518","article-title":"Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis","volume":"45","author":"M Fakiola","year":"2013","journal-title":"Nat Genet"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"KN Couper","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20061141","article-title":"Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis","volume":"204","author":"S Nylen","year":"2007","journal-title":"J Exp Med"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"M Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.it.2007.07.004","article-title":"Interleukin-10 and the pathogenesis of human visceral leishmaniasis","volume":"28","author":"S Nylen","year":"2007","journal-title":"Trends Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"DM Mosser","year":"2008","journal-title":"Immunol Rev"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"R Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"KW Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"294389","DOI":"10.1155\/2010\/294389","article-title":"Cytokines and their STATs in cutaneous and visceral leishmaniasis","volume":"2010","author":"HE Cummings","year":"2010","journal-title":"J Biomed Biotechnol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/eji.1830270409","article-title":"Interleukin-10 and interleukin-4 inhibit intracellular killing of Leishmania infantum and Leishmania major by human macrophages by decreasing nitric oxide generation","volume":"27","author":"I Vouldoukis","year":"1997","journal-title":"Eur J Immunol"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/j.1572-0241.2002.05926.x","article-title":"Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus","volume":"97","author":"S Miyazoe","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.meegid.2011.03.017","article-title":"Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis","volume":"11","author":"Abhimanyu","year":"2011","journal-title":"Infect Genet Evol"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/00365540110077218","article-title":"Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster","volume":"34","author":"M Haanpaa","year":"2002","journal-title":"Scand J Infect Dis"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.gene.6363726","article-title":"IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma","volume":"2","author":"WM Howell","year":"2001","journal-title":"Genes Immun"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1523-1747.2003.12016.x","article-title":"Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation","volume":"120","author":"E Alamartine","year":"2003","journal-title":"J Invest Dermatol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-0039.1999.540408.x","article-title":"Interleukin-10 (IL-10) genotypes in inflammatory bowel disease","volume":"54","author":"A Tagore","year":"1999","journal-title":"Tissue Antigens"},{"issue":"26","key":"ref24","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1073\/pnas.97.26.14467","article-title":"Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10","volume":"97","author":"HD Shin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/infdis\/jir516","article-title":"Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform","volume":"204","author":"S Aggarwal","year":"2011","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2334-13-215","article-title":"Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns","volume":"13","author":"AG Lokossou","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1473-3099(06)70577-1","article-title":"The two faces of interleukin 10 in human infectious diseases","volume":"6","author":"JL Mege","year":"2006","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4049\/jimmunol.0900257","article-title":"Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria\/malaria-coinfected population","volume":"183","author":"S Metenou","year":"2009","journal-title":"J Immunol"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/1529-0131(199906)42:6<1101::AID-ANR6>3.0.CO;2-Y","article-title":"Polymorphic haplotypes of the interleukin-10 5&apos; flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis","volume":"42","author":"E Crawley","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrg1155","article-title":"Mathematical multi-locus approaches to localizing complex human trait genes","volume":"4","author":"J Hoh","year":"2003","journal-title":"Nat Rev Genet"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.clim.2006.01.017","article-title":"Elevated levels of interferon-gamma, interleukin-10, and interleukin-6 during active disease in Indian kala azar","volume":"119","author":"NA Ansari","year":"2006","journal-title":"Clin Immunol"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/infdis\/jir461","article-title":"IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis","volume":"204","author":"S Gautam","year":"2011","journal-title":"J Infect Dis"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"e1874","DOI":"10.1371\/journal.pntd.0001874","article-title":"Cytokine responses to novel antigens in an Indian population living in an area endemic for visceral leishmaniasis","volume":"6","author":"OP Singh","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10753-013-9693-0","article-title":"Is the IL-10\u2013819 polymorphism associated with visceral leishmaniasis?","volume":"36","author":"M Hajilooi","year":"2013","journal-title":"Inflammation"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.4049\/jimmunol.180.9.6139","article-title":"Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis","volume":"180","author":"A Salhi","year":"2008","journal-title":"J Immunol"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000272457","article-title":"Interleukin 10 gene polymorphisms and development of post kala-azar dermal leishmaniasis in a selected sudanese population","volume":"13","author":"S Farouk","year":"2010","journal-title":"Public Health Genomics"},{"issue":"7263","key":"ref37","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nature08365","article-title":"Reconstructing Indian population history","volume":"461","author":"D Reich","year":"2009","journal-title":"Nature"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4269\/ajtmh.2006.75.505","article-title":"Knowledge, attitude, and practices related to Kala-azar in a rural area of Bihar state, India","volume":"75","author":"SP Singh","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-3156.2006.01647.x","article-title":"Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar, India","volume":"11","author":"SP Singh","year":"2006","journal-title":"Trop Med Int Health"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/j.1939-4640.2002.tb02338.x","article-title":"CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations","volume":"23","author":"K Thangaraj","year":"2002","journal-title":"J Androl"},{"key":"ref41","article-title":"R: a language and environment for statistical computing","year":"2009"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.gene.6363920","article-title":"Differential regulation of interleukin-10 production by genetic and environmental factors\u2014a twin study","volume":"3","author":"E Reuss","year":"2002","journal-title":"Genes Immun"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s10552-009-9427-7","article-title":"Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer","volume":"20","author":"KK Tsilidis","year":"2009","journal-title":"Cancer Causes Control"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.jaci.2012.10.043","article-title":"Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma\/wheeze in an urban tropical population in Brazil","volume":"131","author":"CA Figueiredo","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2045-3329-3-12","article-title":"Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations","volume":"3","author":"KM O'Brien","year":"2013","journal-title":"Clin Sarcoma Res"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.gene.6364188","article-title":"Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance","volume":"6","author":"TK Oleksyk","year":"2005","journal-title":"Genes Immun"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.4049\/jimmunol.166.6.3915","article-title":"Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus","volume":"166","author":"AW Gibson","year":"2001","journal-title":"J Immunol"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4049\/jimmunol.165.1.292","article-title":"Posttranscriptional regulation of IL-10 gene expression through sequences in the 3&apos;-untranslated region","volume":"165","author":"MJ Powell","year":"2000","journal-title":"J Immunol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/hmg\/ddm310","article-title":"Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation","volume":"17","author":"A Natividad","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.TP.0000055216.19866.9A","article-title":"Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms","volume":"75","author":"A Suarez","year":"2003","journal-title":"Transplantation"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.humimm.2013.11.009","article-title":"IL10 polymorphisms associated with Behcet&apos;s disease in Chinese Han","volume":"75","author":"Z Wu","year":"2014","journal-title":"Hum Immunol"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","article-title":"Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet&apos;s disease susceptibility loci","volume":"42","author":"N Mizuki","year":"2010","journal-title":"Nat Genet"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ajhg.2013.07.006","article-title":"Genetic evidence for recent population mixture in India","volume":"93","author":"P Moorjani","year":"2013","journal-title":"Am J Hum Genet"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"e48136","DOI":"10.1371\/journal.pone.0048136","article-title":"IL-4 haplotype -590T, -34T and intron-3 VNTR R2 is associated with reduced malaria risk among ancestral indian tribal populations","volume":"7","author":"AN Jha","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/IAI.01041-13","article-title":"MBL2 variations and malaria susceptibility in Indian populations","volume":"82","author":"AN Jha","year":"2014","journal-title":"Infect Immun"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"J Alvar","year":"2012","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref57","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jneuroim.2013.09.019","article-title":"MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"266","author":"J Zhang","year":"2014","journal-title":"J Neuroimmunol"},{"issue":"33\u201334","key":"ref58","first-page":"466","article-title":"MicroRNAs: critical mediators of differentiation, development and disease","volume":"139","author":"JM Friedman","year":"2009","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"A Krek","year":"2005","journal-title":"Nat Genet"},{"issue":"6 Suppl","key":"ref61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4269\/ajtmh.2007.77.69","article-title":"Burden of malaria in India: retrospective and prospective view","volume":"77","author":"A Kumar","year":"2007","journal-title":"Am J Trop Med Hyg"},{"issue":"36","key":"ref62","first-page":"389","article-title":"Leprosy update, 2011","volume":"86","year":"2011","journal-title":"Wkly Epidemiol Rec"},{"key":"ref63","unstructured":"WHO. National Filariasis Control Programme in India and New Strategies for Its Control. (Cited 2005 May14). Available from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int.india\/communicablediseasessurveillances\/filariasis.html\" xlink:type=\"simple\">http:\/\/www.who.int.india\/communicablediseasessurveillances\/filariasis.html<\/ext-link>"},{"key":"ref64","unstructured":"WHO Global tuberculosis report 2012. Geneva2012."},{"key":"ref65","unstructured":"ICMR. Prospects of eliminating lymphatic filariasis in India. ICMR, 2002."},{"key":"ref66","doi-asserted-by":"crossref","first-page":"250868","DOI":"10.1155\/2011\/250868","article-title":"Indian schistosomes: a need for further investigations","volume":"2011","author":"MC Agrawal","year":"2011","journal-title":"J Parasitol Res"},{"key":"ref67","doi-asserted-by":"crossref","DOI":"10.1007\/978-81-322-0539-5","article-title":"Schistosomes and Schistosomiasis in South Asia","author":"M Agrawal","year":"2012"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T20:40:35Z","timestamp":1717879235000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124559"}},"subtitle":[],"editor":[{"given":"Graham R.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,5]]},"references-count":67,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124559","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,5]]}}}