{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:01:55Z","timestamp":1792555315935,"version":"4.5.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124881","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T20:18:09Z","timestamp":1430425089000},"page":"e0124881","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Sodium Thiosulfate Ameliorates Oxidative Stress and Preserves Renal Function in Hyperoxaluric Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"Rakesh K.","family":"Bijarnia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bachtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash G.","family":"Chandak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"ref1","first-page":"398","article-title":"Primary hyperoxaluria","volume":"34","author":"V Lorenzo","year":"2014","journal-title":"Nephrologia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/bju.12642","article-title":"Oxalate at physiological urine concentrations induces oxidative injury in renal epithelial cells: Effect of \u03b1-tocopherol and ascorbic acid","volume":"114","author":"V Thamilselvan","year":"2014","journal-title":"BJU Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/ki.2010.458","article-title":"1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model","volume":"79","author":"HJ Lee","year":"2011","journal-title":"Kidney Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1442-2042.2009.02410.x","article-title":"Renal tubular epithelial cell injury and oxidative stress induce calcium oxalate crystal formation in mouse kidney","volume":"17","author":"M Hirose","year":"2010","journal-title":"Int J Urol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.juro.2007.11.039","article-title":"Reduction of oxidative stress in cultured renal tubular cells and preventive effects on renal stone formation by the bioflavonoid quercetin","volume":"179","author":"HK Park","year":"2008","journal-title":"J Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1365-2230.2012.04350.x","article-title":"Calciphylaxis with normal renal function: treated with intravenous sodium thiosulfate","volume":"37","author":"VM Smith","year":"2012","journal-title":"Clin Exp Dermatol"},{"key":"ref7","first-page":"63","article-title":"Successful sodium thiosulphate treatment for recurrent calcium urolithiasis","volume":"23","author":"H Yatzidis","year":"1985","journal-title":"Clin Nephrol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000092290","article-title":"Sodium thiosulphate as a promising therapeutic option to treat calciphylaxis","volume":"212","author":"M Meissner","year":"2006","journal-title":"Dermatology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/ki.2008.455","article-title":"Sodium thiosulfate prevents vascular calcifications in uremic rats","volume":"74","author":"A Pasch","year":"2008","journal-title":"Kidney Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1681\/ASN.2008070754","article-title":"Thiosulfate reduces calcium phosphate nephrolithiasis","volume":"20","author":"JR Asplin","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2840-4-4","article-title":"Vascular ossification\u2013calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis\u2013calcific uremic arteriolopathy: the emerging role of sodium thiosulfate","volume":"4","author":"MR Hayden","year":"2005","journal-title":"Cardiovasc Diabetol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/end.2008.0204","article-title":"The effect of sodium thiosulfate administration on nephrocalcinosis in a rat model","volume":"23","author":"CA LaGrange","year":"2009","journal-title":"J Endourol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1464-410X.2005.05579.x","article-title":"Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status","volume":"96","author":"S Thamilselvan","year":"2005","journal-title":"BJU Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/path.2698","article-title":"Heparin binding epidermal growth factor in renal ischaemia\/reperfusion injury","volume":"221","author":"GM Mulder","year":"2010","journal-title":"J Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1089-8603(02)00120-9","article-title":"Effect of N acetyl-l-cysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosis","volume":"7","author":"P Failli","year":"2002","journal-title":"Nitric oxide"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2215\/CJN.10241110","article-title":"Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers","volume":"6","author":"S Farese","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/j.1523-1755.2005.00566.x","article-title":"Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells","volume":"68","author":"MS Schepers","year":"2005","journal-title":"Kidney Int"},{"key":"ref18","first-page":"466","article-title":"A polyherbal formulation attenuates hyperoxaluria-induced oxidative stress and prevents subsequent deposition of calcium oxalate crystals and renal cell injury in rat kidneys","volume":"11","author":"KS Bodakhe","year":"2013","journal-title":"Chin J Nat Med"},{"key":"ref19","first-page":"56","article-title":"Severe oxalosis with systemic manifestations","volume":"4","author":"MM Samarneh","year":"2012","journal-title":"J Clin Med Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.juro.2012.05.078","article-title":"Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations","volume":"189","author":"SR Khan","year":"2013","journal-title":"J Urol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1172\/JCI63679","article-title":"Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1\u03b2 secretion","volume":"123","author":"SR Mulay","year":"2013","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00240-011-0388-4","article-title":"Hyperoxaluria-induced tubular ischemia: the effects of verapamil and vitamin E on apoptotic changes with an emphasis on renal papilla in rat model","volume":"40","author":"O Tanriverdi","year":"2012","journal-title":"Urol Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.5301\/ijao.5000309","article-title":"First impressions of cardiovascular calcification treatment in hemodialysis patients with a new dialysis fluid containing sodium thiosulphate (STS)","volume":"37","author":"D Yonova","year":"2014","journal-title":"Int J Artif Organs"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/rheumatology\/ket388","article-title":"Sodium thiosulphate treatment of uraemic tumoral calcinosis","volume":"53","author":"S Malbos","year":"2014","journal-title":"Rheumatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000323550","article-title":"Effects of sodium thiosulfate on vascular calcification in end-stage renal disease: a pilot study of feasibility, safety and efficacy","volume":"33","author":"SJ Mathews","year":"2011","journal-title":"Am J Nephrol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jsb.2013.11.009","article-title":"Mineralisation of soft and hard tissues and the stability of biofluids","volume":"185","author":"C Holt","year":"2014","journal-title":"J Struct Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2010.10.076","article-title":"Antiurolithic effect of berberine is mediated through multiple pathways","volume":"651","author":"S Bashir","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00584263","article-title":"Bidirectional active transport of thiosulfate in the proximal convolution of the rat kidney","volume":"387","author":"K Ullrich","year":"1980","journal-title":"Pflugers Arch"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.bios.2009.12.013","article-title":"Effect of calcium oxalate on renal cells as revealed by real-time measurement of extracellular oxidative burst","volume":"25","author":"S G\u00e1sp\u00e1r","year":"2010","journal-title":"Biosens Bioelectron"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"F1399","DOI":"10.1152\/ajprenal.00051.2009","article-title":"Oxalate-induced activation of PKC-\u03b1 and-\u03b4 regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells","volume":"297","author":"V Thamilselvan","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1093\/ndt\/gfr035","article-title":"Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague\u2013Dawley rats","volume":"26","author":"J Zuo","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00240-001-0228-z","article-title":"Calcium oxalate stone disease: role of lipid peroxidation and antioxidants","volume":"30","author":"R Selvam","year":"2002","journal-title":"Urol Res"},{"key":"ref33","first-page":"62","article-title":"Effect of renal ischaemia reperfusion on calcium oxalate retention","volume":"111","author":"R Selvam","year":"2000","journal-title":"Indian J Med Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.freeradbiomed.2005.02.020","article-title":"Crystal and microparticle effects on MDCK cell superoxide production: oxalate-specific mitochondrial membrane potential changes","volume":"38","author":"E Meimaridou","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"18515","DOI":"10.1074\/jbc.272.30.18515","article-title":"Superoxide Anion Radical (O2<sup>-<\/sup>), Superoxide Dismutases, and Related Matters","volume":"272","author":"I Fridovich","year":"1997","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.enzmictec.2008.10.012","article-title":"Liposome membrane can act like molecular and metal chaperones for oxidized and fragmented superoxide dismutase","volume":"44","author":"LQ Tuan","year":"2009","journal-title":"Enzyme Mocrob Technol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3866\/PKU.WHXB20040722","article-title":"Dependence of the H<sub>2<\/sub>O<sub>2<\/sub>-Na<sub>2<\/sub> S<sub>2<\/sub>O<sub>3<\/sub> Reaction on pH and [H<sub>2<\/sub>O<sub>2<\/sub>]\/ [Na<sub>2<\/sub> S<sub>2<\/sub>O<sub>3<\/sub>]","volume":"20","author":"KY Xue","year":"2004","journal-title":"Acta Phys Chim Sin"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.fct.2008.03.007","article-title":"Modulatory effects of N-acetylcysteine on hyperoxaluric manifestations in rat kidney","volume":"46","author":"RK Bijarnia","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1152\/ajprenal.90309.2008","article-title":"Low-vitamin E diet exacerbates calcium oxalate crystal formation via enhanced oxidative stress in rat hyperoxaluric kidney","volume":"296","author":"HS Huang","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0002-9343(00)00612-4","article-title":"Reactive oxygen species and acute renal failure","volume":"109","author":"KA Nath","year":"2010","journal-title":"Am J Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00240-009-0197-1","article-title":"Taurine protected kidney from oxidative injury through mitochondrial-linked pathway in a rat model of nephrolithiasis","volume":"37","author":"CY Li","year":"2009","journal-title":"Urol Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.M800021200","article-title":"Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling","volume":"283","author":"CH Byon","year":"2008","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.2013050497","article-title":"Urinary Sulfur Metabolites are Associated with a Favorable Cardiovascular Risk Profile and Survival Benefit in Renal Transplant Recipients","volume":"25","author":"E van den Berg","year":"2014","journal-title":"J Am Soc Nephrol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T17:10:59Z","timestamp":1598980259000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124881"}},"subtitle":[],"editor":[{"given":"Utpal","family":"Sen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124881","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,30]]}}}