{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:43:10Z","timestamp":1791207790644,"version":"4.1.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0124977","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T17:52:31Z","timestamp":1430157151000},"page":"e0124977","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["Tracking the Elusive Function of Bacillus subtilis Hfq"],"prefix":"10.1371","volume":"10","author":[{"given":"Tatiana","family":"Rochat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Delumeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara","family":"Figueroa-Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Noirot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionello","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Dervyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bouloc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mib.2007.03.015","article-title":"Hfq structure, function and ligand binding","volume":"10","author":"RG Brennan","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1365-2958.2003.03935.x","article-title":"The bacterial Sm-like protein Hfq: a key player in RNA transactions","volume":"51","author":"P Valentin-Hansen","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nrmicro2615","article-title":"Hfq and its constellation of RNA","volume":"9","author":"J Vogel","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0021-9258(19)45681-0","article-title":"Bacterial proteins required for replication of phage Q ribonucleic acid. Purification and properties of host factor I, a ribonucleic acid-binding protein","volume":"247","author":"MT Franze de Fernandez","year":"1972","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2958.1994.tb00400.x","article-title":"Characterization of broadly pleiotropic phenotypes caused by an <italic>hfq<\/italic> insertion mutation in <italic>Escherichia coli<\/italic> K-12","volume":"13","author":"HC Tsui","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.molcel.2011.08.022","article-title":"Regulation by small RNAs in bacteria: expanding frontiers","volume":"43","author":"G Storz","year":"2011","journal-title":"Mol Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.mib.2007.03.010","article-title":"Mechanism of RNA silencing by Hfq-binding small RNAs","volume":"10","author":"H Aiba","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.biochi.2008.06.001","article-title":"Porin biogenesis activates the sigma(E) response in <italic>Salmonella hfq<\/italic> mutants","volume":"90","author":"L Bossi","year":"2008","journal-title":"Biochimie"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1093\/nar\/gkf508","article-title":"Predicted structure and phyletic distribution of the RNA-binding protein Hfq","volume":"30","author":"X Sun","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1093\/emboj\/cdf322","article-title":"Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein","volume":"21","author":"MA Schumacher","year":"2002","journal-title":"EMBO J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2180-7-10","article-title":"No detectable effect of RNA-binding protein Hfq absence in <italic>Staphylococcus aureus<\/italic>","volume":"7","author":"C Bohn","year":"2007","journal-title":"BMC Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/j.1365-2958.2006.05292.x","article-title":"Inhibition of <italic>rot<\/italic> translation by RNAIII, a key feature of <italic>agr<\/italic> function","volume":"61","author":"E Geisinger","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref13","article-title":"Hfq is a global regulator that controls the pathogenicity of <italic>Staphylococcus aureus<\/italic>","volume":"5","author":"Y Liu","year":"2010","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1101\/gad.423507","article-title":"<italic>Staphylococcus aureus<\/italic> RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism","volume":"21","author":"S Boisset","year":"2007","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1093\/nar\/gkp668","article-title":"A search for small noncoding RNAs in <italic>Staphylococcus aureus<\/italic> reveals a conserved sequence motif for regulation","volume":"37","author":"T Geissmann","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1000927","DOI":"10.1371\/journal.ppat.1000927","article-title":"A <italic>Staphylococcus aureus<\/italic> small RNA is required for bacterial virulence and regulates the expression of an immune-evasion molecule","volume":"6","author":"S Chabelskaya","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.biochi.2012.01.016","article-title":"Lack of interchangeability of Hfq-like proteins","volume":"94","author":"T Rochat","year":"2012","journal-title":"Biochimie"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1128\/JB.186.11.3355-3362.2004","article-title":"The RNA-binding protein Hfq of <italic>Listeria monocytogenes<\/italic>: role in stress tolerance and virulence","volume":"186","author":"JK Christiansen","year":"2004","journal-title":"J Bacteriol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1261\/rna.49706","article-title":"Identification of small Hfq-binding RNAs in <italic>Listeria monocytogenes<\/italic>","volume":"12","author":"JK Christiansen","year":"2006","journal-title":"RNA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/nar\/gkp1081","article-title":"Defining a role for Hfq in Gram-positive bacteria: evidence for Hfq-dependent antisense regulation in Listeria monocytogenes","volume":"38","author":"JS Nielsen","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e19019","DOI":"10.1371\/journal.pone.0019019","article-title":"A small RNA controls expression of the chitinase ChiA in <italic>Listeria monocytogenes<\/italic>","volume":"6","author":"JS Nielsen","year":"2011","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/nar\/gkl1096","article-title":"Identification of new noncoding RNAs in <italic>Listeria monocytogenes<\/italic> and prediction of mRNA targets","volume":"35","author":"P Mandin","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nature08080","article-title":"The <italic>Listeria<\/italic> transcriptional landscape from saprophytism to virulence","volume":"459","author":"A Toledo-Arana","year":"2009","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1261\/rna.044032.113","article-title":"Recognition of U-rich RNA by Hfq from the Gram-positive pathogen <italic>Listeria monocytogenes<\/italic>","volume":"20","author":"AR Kovach","year":"2014","journal-title":"RNA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1093\/nar\/gkt1171","article-title":"Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching","volume":"42","author":"KE Robinson","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1128\/JB.187.19.6641-6650.2005","article-title":"Small untranslated RNA antitoxin in <italic>Bacillus subtilis<\/italic>","volume":"187","author":"JM Silvaggi","year":"2005","journal-title":"J Bacteriol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e98661","DOI":"10.1371\/journal.pone.0098661","article-title":"Impact of Hfq on the <italic>Bacillus subtilis<\/italic> transcriptome","volume":"9","author":"H Hammerle","year":"2014","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055156","article-title":"Association of RNAs with <italic>Bacillus subtilis<\/italic> Hfq","volume":"8","author":"M Dambach","year":"2013","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2958.2006.05384.x","article-title":"The small untranslated RNA SR1 from the <italic>Bacillus subtilis<\/italic> genome is involved in the regulation of arginine catabolism","volume":"62","author":"N Heidrich","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1093\/nar\/gkm439","article-title":"<italic>In vitro<\/italic> analysis of the interaction between the small RNA SR1 and its primary target ahrC mRNA","volume":"35","author":"N Heidrich","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"11927","DOI":"10.1073\/pnas.0711752105","article-title":"The <italic>Bacillus subtilis<\/italic> iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins","volume":"105","author":"A Gaballa","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1004957","DOI":"10.1371\/journal.pgen.1004957","article-title":"A Nitric Oxide Regulated Small RNA Controls Expression of Genes Involved in Redox Homeostasis in <italic>Bacillus subtilis<\/italic>","volume":"11","author":"S Durand","year":"2015","journal-title":"PLoS Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1128\/JB.184.17.4881-4890.2002","article-title":"Genome-wide analysis of the stationary-phase sigma factor (sigma-H) regulon of <italic>Bacillus subtilis<\/italic>","volume":"184","author":"RA Britton","year":"2002","journal-title":"J Bacteriol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1126\/science.1206848","article-title":"Condition-dependent transcriptome reveals high-level regulatory architecture in <italic>Bacillus subtilis<\/italic>","volume":"335","author":"P Nicolas","year":"2012","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1574-6976.2008.00149.x","article-title":"Global phenotypic characterization of bacteria","volume":"33","author":"BR Bochner","year":"2009","journal-title":"FEMS Microbiol Rev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00018-002-8431-9","article-title":"<italic>Bacillus subtilis<\/italic> sporulation and stationary phase gene expression","volume":"59","author":"ZE Phillips","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"11621","DOI":"10.1073\/pnas.191384198","article-title":"Fruiting body formation by <italic>Bacillus subtilis<\/italic>","volume":"98","author":"SS Branda","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1365-2958.2009.06830.x","article-title":"The transcriptionally active regions in the genome of <italic>Bacillus subtilis<\/italic>","volume":"73","author":"S Rasmussen","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1093\/nar\/gkq454","article-title":"Identification of regulatory RNAs in Bacillus subtilis","volume":"38","author":"I Irnov","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1093\/nar\/gkq462","article-title":"Experimental discovery of small RNAs in <italic>Staphylococcus aureus<\/italic> reveals a riboregulator of central metabolism","volume":"38","author":"C Bohn","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1128\/JB.187.4.1357-1368.2005","article-title":"High- and low-threshold genes in the Spo0A regulon of <italic>Bacillus subtilis<\/italic>","volume":"187","author":"M Fujita","year":"2005","journal-title":"J Bacteriol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1128\/JB.00534-10","article-title":"Small genes under sporulation control in the <italic>Bacillus subtilis<\/italic> genome","volume":"192","author":"M Schmalisch","year":"2010","journal-title":"J Bacteriol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1574-6976.2010.00253.x","article-title":"Cannibalism: a social behavior in sporulating <italic>Bacillus subtilis<\/italic>","volume":"35","author":"JE Gonzalez-Pastor","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1101\/gad.541609","article-title":"Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target","volume":"23","author":"N Figueroa-Bossi","year":"2009","journal-title":"Genes Dev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1365-2958.2011.07751.x","article-title":"Pervasive post-transcriptional control of genes involved in amino acid metabolism by the Hfq-dependent GcvB small RNA","volume":"81","author":"CM Sharma","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"12253","DOI":"10.1074\/jbc.M600819200","article-title":"Down-regulation of porins by a small RNA bypasses the essentiality of the regulated intramembrane proteolysis protease RseP in <italic>Escherichia coli<\/italic>","volume":"281","author":"V Douchin","year":"2006","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1365-2958.2006.05413.x","article-title":"Loss of Hfq activates the sigmaE-dependent envelope stress response in <italic>Salmonella enterica<\/italic>","volume":"62","author":"N Figueroa-Bossi","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1128\/JB.01243-06","article-title":"Hfq modulates the sigmaE-mediated envelope stress response and the sigma32-mediated cytoplasmic stress response in <italic>Escherichia coli<\/italic>","volume":"189","author":"E Guisbert","year":"2007","journal-title":"J Bacteriol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/j.1365-2958.2006.05524.x","article-title":"SigmaE-dependent small RNAs of <italic>Salmonella<\/italic> respond to membrane stress by accelerating global omp mRNA decay","volume":"62","author":"K Papenfort","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1128\/JB.01923-14","article-title":"Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen <italic>Clostridium difficile<\/italic>","volume":"196","author":"P Boudry","year":"2014","journal-title":"J Bacteriol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1261\/rna.043372.113","article-title":"<italic>Clostridium difficile<\/italic> Hfq can replace Escherichia coli Hfq for most of its function","volume":"20","author":"J Caillet","year":"2014","journal-title":"RNA"},{"issue":"Pt 11","key":"ref52","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1099\/00221287-144-11-3097","article-title":"A vector for systematic gene inactivation in <italic>Bacillus subtilis<\/italic>","volume":"144","author":"V Vagner","year":"1998","journal-title":"Microbiology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1365-2958.1994.tb01042.x","article-title":"Frequency of deletion formation decreases exponentially with distance between short direct repeats","volume":"12","author":"F Chedin","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-1119(94)90358-1","article-title":"Plasmids designed to alter the antibiotic resistance expressed by insertion mutations in <italic>Bacillus subtilis<\/italic>, through <italic>in vivo<\/italic> recombination","volume":"142","author":"M Steinmetz","year":"1994","journal-title":"Gene"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/molbev\/msg219","article-title":"Genome engineering reveals large dispensable regions in <italic>Bacillus subtilis<\/italic>","volume":"20","author":"H Westers","year":"2003","journal-title":"Mol Biol Evol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/nar\/gks963","article-title":"Building the repertoire of dispensable chromosome regions in <italic>Bacillus subtilis<\/italic> entails major refinement of cognate large-scale metabolic model","volume":"41","author":"K Tanaka","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref57","article-title":"Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in <italic>Bacillus subtilis<\/italic>","author":"T Rochat","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/pr034084x","article-title":"Sequential Peptide Affinity (SPA) system for the identification of mammalian and bacterial protein complexes","volume":"3","author":"M Zeghouf","year":"2004","journal-title":"J Proteome Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1038\/sj.emboj.7601848","article-title":"Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks","volume":"26","author":"F Lecointe","year":"2007","journal-title":"EMBO J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2958.1997.4451807.x","article-title":"Unsuspected prophage-like elements in <italic>Salmonella typhimurium<\/italic>","volume":"25","author":"N Figueroa-Bossi","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0076-6879(06)21016-4","article-title":"\u03bb-Red genetic engineering in <italic>Salmonella enterica<\/italic> serovar Typhimurium","author":"JE Karlinsey","year":"2007","journal-title":"Methods Enzymol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"15264","DOI":"10.1073\/pnas.261348198","article-title":"Epitope tagging of chromosomal genes in Salmonella","volume":"98","author":"S Uzzau","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1365-2958.2007.05829.x","article-title":"A small RNA downregulates LamB maltoporin in <italic>Salmonella<\/italic>","volume":"65","author":"L Bossi","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1365-2958.2012.08144.x","article-title":"RNase Y of <italic>Staphylococcus aureus<\/italic> and its role in the activation of virulence genes","volume":"85","author":"G Marincola","year":"2012","journal-title":"Mol Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1128\/JB.186.12.3970-3979.2004","article-title":"Genes involved in formation of structured multicellular communities by <italic>Bacillus subtilis<\/italic>","volume":"186","author":"SS Branda","year":"2004","journal-title":"J Bacteriol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"R Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref68","first-page":"466","article-title":"Experiments in molecular genetics","volume":"xvi","author":"JH Miller","year":"1972"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0124977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T05:14:26Z","timestamp":1651814066000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0124977"}},"subtitle":[],"editor":[{"given":"Lennart","family":"Randau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0124977","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,27]]}}}