{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:40Z","timestamp":1791354100812,"version":"4.3.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0125203","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T17:30:04Z","timestamp":1434130204000},"page":"e0125203","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma"],"prefix":"10.1371","volume":"10","author":[{"given":"Ana M.","family":"Mart\u00edn-Moreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Roncador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Maestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scherezade","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Mart\u00ednez-Torrecuadrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Reyes-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 F.","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Est\u00e9vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Pulford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Piris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.184.4.1495","article-title":"Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells","volume":"184","author":"H Kanzler","year":"1996","journal-title":"J Exp Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1200\/JCO.2010.32.8401","article-title":"Molecular Pathogenesis of Hodgkin's Lymphoma: Increasing Evidence of the Importance of the Microenvironment","volume":"29","author":"C Steidl","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1182\/blood-2002-01-0099","article-title":"The role of cytokines in classical Hodgkin lymphoma","volume":"99","author":"BF Skinnider","year":"2002","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1158\/1078-0432.CCR-04-1869","article-title":"Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells","volume":"11","author":"T Alvaro","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.humpath.2009.03.025","article-title":"Increased programmed death-1+ tumor-infiltrating lymphocytes in classical Hodgkin lymphoma substantiate reduced overall survival","volume":"40","author":"S Muenst","year":"2009","journal-title":"Hum Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3324\/haematol.11702","article-title":"Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma","volume":"93","author":"A Tzankov","year":"2008","journal-title":"Haematologica"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1182\/blood-2005-12-5125","article-title":"Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma","volume":"108","author":"A Sanchez-Aguilera","year":"2006","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1182\/blood-2008-07-168096","article-title":"Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome","volume":"113","author":"B Chetaille","year":"2009","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1038\/sj.onc.1205418","article-title":"Gene expression profiling defines molecular subtypes of classical Hodgkin's disease","volume":"21","author":"E Devilard","year":"2002","journal-title":"Oncogene"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa0905680","article-title":"Tumor-associated macrophages and survival in classic Hodgkin's lymphoma","volume":"362","author":"C Steidl","year":"2010","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3109\/10428194.2011.580026","article-title":"The prognostic relevance of tumor associated macrophages in advanced stage classical Hodgkin lymphoma","volume":"52","author":"LR Jakovic","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3324\/haematol.2010.031542","article-title":"Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma","volume":"96","author":"P Kamper","year":"2011","journal-title":"Haematologica"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3324\/haematol.2011.055459","article-title":"Immunohistochemical markers for tumor associated macrophages and survival in advanced classical Hodgkin's lymphoma","volume":"97","author":"B S\u00e1nchez-Espiridi\u00f3n","year":"2012","journal-title":"Haematologica"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/annonc\/mdr157","article-title":"Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma","volume":"23","author":"D Azambuja","year":"2012","journal-title":"Ann Oncol"},{"key":"ref15","first-page":"153","article-title":"The prognostic value of biologic markers in classical hodgkin lymphoma (CHL) patients","volume":"22","author":"C Agostinelli","year":"2011","journal-title":"Ann Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10555-006-9001-7","article-title":"Role of tumor-associated macrophages in tumor progression and invasion","volume":"25","author":"A Mantovani","year":"2006","journal-title":"Cancer metastasis rev"},{"key":"ref17","first-page":"1605","article-title":"The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma","volume":"91","author":"T Alvaro","year":"2006","journal-title":"Haematologica"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1182\/blood-2005-04-1565","article-title":"Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)","volume":"106","author":"P Farinha","year":"2005","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa041869","article-title":"Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells","volume":"351","author":"SS Dave","year":"2004","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1200\/JCO.2007.12.8298","article-title":"High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial","volume":"26","author":"D Canioni","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jcb.240500403","article-title":"M-CSF (monocyte colony stimulating factor) and M-CSF receptor expression by breast tumour cells: M-CSF mediated recruitment of tumour infiltrating monocytes?","volume":"50","author":"R Tang","year":"1992","journal-title":"J Cell Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","article-title":"CSF-1 regulation of the wandering macrophage: complexity in action","volume":"14","author":"FJ Pixley","year":"2004","journal-title":"Trends Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1182\/blood-2012-06-439570","article-title":"Gene expression profiling of microdissected Hodgkin Reed Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma","volume":"120","author":"C Steidl","year":"2012","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nm.2129","article-title":"Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma","volume":"16","author":"B Lamprecht","year":"2010","journal-title":"Nat Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2141.2011.08685.x","article-title":"BAY 43-9006\/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines","volume":"155","author":"K Ullrich","year":"2011","journal-title":"Br J Haematol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.4049\/jimmunol.1200675","article-title":"SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis","volume":"189","author":"B Madan","year":"2012","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.4049\/jimmunol.1000475","article-title":"Dendritic cell-specific ICAM-3-grabbing nonintegrin expression on M2-polarized and tumor-associated macrophages is macrophage-CSF dependent and enhanced by tumor-derived IL-6 and IL-10","volume":"186","author":"A Dom\u00ednguez-Soto","year":"2011","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/blood-2012-04-421057","article-title":"Tumor-associated macrophages predict inferior outcomes in classical Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial","volume":"120","author":"KL Tan","year":"2012","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1158\/0008-5472.CAN-12-3981","article-title":"CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer","volume":"73","author":"J Xu","year":"2013","journal-title":"Cancer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1182\/blood-2012-04-422758","article-title":"Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages","volume":"120","author":"H He","year":"2012","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri2528","article-title":"Trophic macrophages in development and disease","volume":"9","author":"JW Pollard","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"BZ Qian","year":"2010","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1189\/jlb.1105656","article-title":"Dual role of macrophages in tumor growth and angiogenesis","volume":"80","author":"C Lamagna","year":"2006","journal-title":"J Leukoc Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"DF Quail","year":"2013","journal-title":"Nat Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/path.4192","article-title":"Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response","volume":"230","author":"M Sielska","year":"2013","journal-title":"J Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.ajpath.2011.06.021","article-title":"CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis","volume":"179","author":"I Espinosa","year":"2011","journal-title":"Am J Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.2353\/ajpath.2009.081037","article-title":"Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma","volume":"174","author":"I Espinosa","year":"2009","journal-title":"Am J Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1189\/jlb.1209822","article-title":"Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells","volume":"88","author":"S Wei","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-05-4005","article-title":"Distinct role of macrophages in different tumor microenvironments","volume":"66","author":"CE Lewis","year":"2006","journal-title":"Cancer Res"},{"key":"ref40","first-page":"315","article-title":"Expression of macrophage colony-stimulating factor (M-CSF) in two Hodgkin's Reed-Sternberg (H-RS) cell lines, HDLM-1 and KM-H2, and in H-RS cells in tissues","volume":"54","author":"PL Hsu","year":"1991","journal-title":"Int J Hematol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1309\/AJCPR92TDDFARISU","article-title":"CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma","volume":"141","author":"YW Koh","year":"2014","journal-title":"Am J Clin Pathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1182\/blood-2010-02-266296","article-title":"An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation","volume":"116","author":"KP MacDonald","year":"2010","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1158\/0008-5472.CAN-04-1449","article-title":"A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors","volume":"64","author":"J Wyckoff","year":"2004","journal-title":"Cancer Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/0008-5472.CAN-12-2731","article-title":"Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses","volume":"73","author":"JB Mitchem","year":"2013","journal-title":"Cancer Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1158\/1535-7163.MCT-09-0255","article-title":"JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor\/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia","volume":"8","author":"CL Manthey","year":"2009","journal-title":"Mol Cancer Ther"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ccr.2014.05.016","article-title":"Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy","volume":"25","author":"CH Ries","year":"2014","journal-title":"Cancer Cell"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0125203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T22:40:49Z","timestamp":1540334449000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0125203"}},"subtitle":[],"editor":[{"given":"Pankaj K","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0125203","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]}}}