{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:14:05Z","timestamp":1787696045629,"version":"build-2784847793"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0125231","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T18:00:56Z","timestamp":1434045656000},"page":"e0125231","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma"],"prefix":"10.1371","volume":"10","author":[{"given":"Tomoki","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuno","family":"Nishibuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kenjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohji","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.510260117","article-title":"Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: Activation of hepatic stellate cells as an early event","volume":"26","author":"C Sempoux","year":"1997","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1016\/j.ijrobp.2011.04.011","article-title":"Stereotactic body radiotherapy for primary hepatocellular carcinoma","volume":"81","author":"DL Andolino","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1872-034X.2007.00084.x","article-title":"Hypofractionated stereotactic radiotherapy with and without transarterial chemoembolization for small hepatocellular carcinoma not eligible for other ablation therapies: Preliminary results for efficacy and toxicity","volume":"38","author":"A Takeda","year":"2008","journal-title":"Hepatol Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.ijrobp.2008.10.073","article-title":"A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma","volume":"74","author":"N Fukumitsu","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ijrobp.2004.01.032","article-title":"Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis","volume":"59","author":"H Kato","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0360-3016(03)00586-8","article-title":"Assessment of focal liver reaction by multiphasic CR after stereortactic single-dose radiotherapy of liver tumors","volume":"57","author":"KK Herfarth","year":"2003","journal-title":"Int. J. Radiation Oncology Biol. Phys"},{"key":"ref7","first-page":"39","article-title":"Stereotactic Body Radiation Therapy","author":"J Wulf","year":"2005"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1259\/bjr\/74105551","article-title":"CT evaluations of focal liver reactions following stereotactic body radiotherapy for small hepatocellular carcinoma with cirrhosis: relationship between imaging appearance and baseline liver function","volume":"83","author":"N Sanuki-Fujimoto","year":"2010","journal-title":"BJR"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/hepr.12007","article-title":"Dynamic Computed Tomography Appearance of Tumor Response after Stereotactic Body Radiation Therapy for hepatocellular Carcinoma-How should we evaluate treatment effects?-","volume":"43","author":"T Kimura","year":"2013","journal-title":"Hepatol Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.ijrobp.2004.07.718","article-title":"Reproducibility of organ position using voluntary breath-hold with spirometer for extracranial stereotactic radiotherapy","volume":"60","author":"T Kimura","year":"2004","journal-title":"Int. J. Radiation Oncology Biol. Phys"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1259\/bjr.73.869.10884753","article-title":"Acute radiation-induced hepatic injury: evaluation by triphasic contrast enhanced helical CT","volume":"73","author":"S Willemart","year":"2000","journal-title":"BJR"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00004728-198703000-00013","article-title":"CT and MR imaging of radiation hepatitis","volume":"11","author":"EC Unger","year":"1987","journal-title":"J Comput Assist Tomogr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00004728-199409000-00025","article-title":"Focused radiation hepatitis after bragg-peak proton therapy for hepatocellular carcinoma: CT findings","volume":"18","author":"T Okumura","year":"1994","journal-title":"J Comput Assist Tomogr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.semradonc.2011.05.003","article-title":"Hepatic radiation toxicity: Avoidance and amelioration","volume":"21","author":"C Guha","year":"2011","journal-title":"Seminars in Radiation Oncology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ijrobp.2008.07.032","article-title":"Microscopic and macroscopic tumor and parenchymal effects of liver stereotactic body radiotherapy","volume":"73","author":"CC Olsen","year":"2009","journal-title":"Int. J. Radiation Oncology Biol. Phys"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/gut.34.4.554","article-title":"Hepatic perfusion changes in patients with liver metastases: comparison with those patients with cirrhosis","volume":"34","author":"E Leen","year":"1993","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1172\/JCI113828","article-title":"Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis","volume":"82","author":"J Reichen","year":"1988","journal-title":"J Clin Invest"},{"key":"ref18","first-page":"677","article-title":"Assessment of the severity of liver disease and fibrotic change: the usefulness of hepatic CT perfusion imaging","volume":"16","author":"K Hashimoto","year":"2006","journal-title":"Oncol Rep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jmri.21956","article-title":"Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: Which biological markers of the liver function affect the enhancement?","volume":"30","author":"U Motosugi","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijrobp.2013.10.045","article-title":"Threshold Doses for Focal Liver Reaction After Stereotactic Ablative Body Radiation Therapy for Small Hepatocellular Carcinoma Depend on Liver Function: Evaluation on Magnetic Resonance Imaging With Gd-EOB-DTPA","volume":"88","author":"N Sanuki","year":"2014","journal-title":"Int. J. Radiation Oncology Biol. Phys"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0125231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T22:35:35Z","timestamp":1540247735000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0125231"}},"subtitle":[],"editor":[{"given":"Taro","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,11]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0125231","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,11]]}}}