{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:57:18Z","timestamp":1774987038646,"version":"3.50.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0125420","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T18:11:00Z","timestamp":1430503860000},"page":"e0125420","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epstein\u2013Barr Virus Genetic Variation in Lymphoblastoid Cell Lines Derived from Kenyan Pediatric Population"],"prefix":"10.1371","volume":"10","author":[{"given":"Kenneth O.","family":"Simbiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Otieno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric E. M.","family":"Wohlford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim I.","family":"Daud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumba P.","family":"Odada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Rochford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pathol.1.110304.100209","article-title":"Spectrum of Epstein-Barr virus-associated diseases","volume":"1","author":"JL Kutok","year":"2006","journal-title":"Annu Rev Pathol"},{"issue":"1408","key":"ref2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1098\/rstb.2000.0775","article-title":"Molecular evolution of the gamma-Herpesvirinae","volume":"356","author":"DJ McGeoch","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2006.10.009","article-title":"Lineage structures in the genome sequences of three Epstein-Barr virus strains","volume":"359","author":"DJ McGeoch","year":"2007","journal-title":"Virology"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1128\/JVI.64.9.4084-4092.1990","article-title":"Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes","volume":"64","author":"J Sample","year":"1990","journal-title":"J Virol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/viro.1999.9855","article-title":"Signature amino acid changes in latent membrane protein 1 distinguish Epstein-Barr virus strains","volume":"261","author":"RH Edwards","year":"1999","journal-title":"Virology"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/JVI.78.2.868-881.2004","article-title":"Potential selection of LMP1 variants in nasopharyngeal carcinoma","volume":"78","author":"RH Edwards","year":"2004","journal-title":"J Virol"},{"issue":"Pt 10","key":"ref7","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1099\/vir.0.021881-0","article-title":"Widespread sequence variation in the Epstein-Barr virus latent membrane protein 2A gene among northern Chinese isolates","volume":"91","author":"X Wang","year":"2010","journal-title":"J Gen Virol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jinf.2006.04.015","article-title":"Characterization of variants in the promoter of EBV gene BZLF1 in normal donors, HIV-positive patients and in AIDS-related lymphomas","volume":"54","author":"M Martini","year":"2007","journal-title":"J Infect"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/jmv.21871","article-title":"EBNA1 sequences in Argentinean pediatric acute and latent Epstein-Barr virus infection reflect circulation of novel South American variants","volume":"82","author":"MA Lorenzetti","year":"2010","journal-title":"J Med Virol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/JVI.73.2.965-975.1999","article-title":"Epstein-barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt&apos;s lymphoma reflect virus strains prevalent in different geographic areas","volume":"73","author":"G Habeshaw","year":"1999","journal-title":"J Virol"},{"issue":"Pt 1","key":"ref11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1099\/0022-1317-75-1-95","article-title":"Heterogeneity within the Epstein-Barr virus nuclear antigen 2 gene in different strains of Epstein-Barr virus","volume":"75","author":"C Aitken","year":"1994","journal-title":"J Gen Virol"},{"issue":"1\u20132","key":"ref12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virusres.2005.11.020","article-title":"Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes","volume":"118","author":"I G\u00f6rzer","year":"2006","journal-title":"Virus Res"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.virusres.2009.07.005","article-title":"The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: a need for reappraisal","volume":"143","author":"CM Chang","year":"2009","journal-title":"Virus Res"},{"issue":"Pt 5","key":"ref14","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1099\/vir.0.030023-0","article-title":"Epstein-Barr virus latent gene sequences as geographical markers of viral origin: unique EBNA3 gene signatures identify Japanese viruses as distinct members of the Asian virus family","volume":"92","author":"A Sawada","year":"2011","journal-title":"J Gen Virol"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1128\/JVI.70.8.4895-4903.1996","article-title":"Isolation of intertypic recombinants of Epstein-Barr virus from T-cell-immunocompromised individuals","volume":"70","author":"QY Yao","year":"1996","journal-title":"J Virol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/JVI.02517-12","article-title":"Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains","volume":"87","author":"Z Lin","year":"2013","journal-title":"J Virol"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"e36939","DOI":"10.1371\/journal.pone.0036939","article-title":"Genomic sequencing and comparative analysis of Epstein-Barr virus genome isolated from primary nasopharyngeal carcinoma biopsy","volume":"7","author":"H Kwok","year":"2012","journal-title":"PLoS One"},{"issue":"18","key":"ref18","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1128\/JVI.01665-14","article-title":"Genomic diversity of Epstein-Barr virus genomes isolated from primary nasopharyngeal carcinoma biopsies","volume":"88","author":"H Kwok","year":"2014","journal-title":"J Virol"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/infdis\/jir872","article-title":"Early age at time of primary Epstein-Barr virus infection results in poorly controlled viral infection in infants from Western Kenya: clues to the etiology of endemic Burkitt lymphoma","volume":"205","author":"E Piriou","year":"2012","journal-title":"J Infect Dis"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/pathogens1020156","article-title":"Epstein-Barr Virus Sequence Variation-Biology and Disease","volume":"1","author":"S Tzellos","year":"2012","journal-title":"Pathogens"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0042-6822(85)90253-3","article-title":"A putative transforming gene of Jijoye virus differs from that of Epstein-Barr virus prototypes","volume":"141","author":"HK Adldinger","year":"1985","journal-title":"Virology"},{"issue":"12","key":"ref22","first-page":"3372","article-title":"Precision of genotyping of Epstein-Barr virus by polymerase chain reaction using three gene loci (EBNA-2, EBNA-3C, and EBER): predominance of type A virus associated with Hodgkin&apos;s disease","volume":"81","author":"JC Lin","year":"1993","journal-title":"Blood"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.4049\/jimmunol.169.3.1593","article-title":"Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt&apos;s lymphoma cells","volume":"169","author":"C Paludan","year":"2002","journal-title":"J Immunol"},{"issue":"16","key":"ref24","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1128\/JVI.00400-06","article-title":"CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes","volume":"80","author":"CW Tsang","year":"2006","journal-title":"J Virol"},{"issue":"21","key":"ref25","doi-asserted-by":"crossref","first-page":"10142","DOI":"10.1128\/JVI.74.21.10142-10152.2000","article-title":"Infectious Epstein-Barr virus lacking major glycoprotein BLLF1 (gp350\/220) demonstrates the existence of additional viral ligands","volume":"74","author":"A Janz","year":"2000","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/JVI.61.5.1416-1420.1987","article-title":"Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV\/C3d receptor of B cells: sequence homology of gp350 and C3 complement fragment C3d","volume":"61","author":"G R Nemerow","year":"1987","journal-title":"J Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1128\/JVI.43.2.730-736.1982","article-title":"Identification and isolation of the main component (gp350-gp220) of Epstein-Barr virus responsible for generating neutralizing antibodies in vivo","volume":"43","author":"D A Thorley-Lawson","year":"1982","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)81363-X","article-title":"Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF\/NGF receptor family","volume":"87","author":"R Montgomery","year":"1996","journal-title":"Cell"},{"issue":"46","key":"ref29","doi-asserted-by":"crossref","first-page":"16286","DOI":"10.1073\/pnas.0407320101","article-title":"Proteins of purified Epstein-Barr virus","volume":"101","author":"E Johannsen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.virusres.2009.07.007","article-title":"Functional roles of the tegument proteins of herpes simplex virus type 1","volume":"145","author":"BJ Kelly","year":"2009","journal-title":"Virus Res"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1073\/pnas.0404521102","article-title":"Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis","volume":"102","author":"MJ Song","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"e53512","DOI":"10.1371\/journal.pone.0053512","article-title":"An RS motif within the Epstein-Barr virus BLRF2 tegument protein is phosphorylated by SRPK2 and is important for viral replication","volume":"8","author":"M Duarte","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/0042-6822(91)90574-U","article-title":"Early events in Epstein-Barr virus genome expression after activation: regulation by second messengers of B cell activation","volume":"185","author":"I Mellinghoff","year":"1991","journal-title":"Virology"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1128\/JVI.02020-12","article-title":"Epstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-\u03baB signaling during productive replication","volume":"87","author":"S Saito","year":"2013","journal-title":"J Virol"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1128\/JVI.02195-08","article-title":"The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity","volume":"83","author":"CB Whitehurst","year":"2009","journal-title":"J Virol"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1023\/B:VIRU.0000036387.39937.9b","article-title":"The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16","volume":"29","author":"S Schmaus","year":"2004","journal-title":"Virus Genes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1128\/JVI.02195-08","article-title":"The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity","volume":"83","author":"CB Whitehurst","year":"2009","journal-title":"J. Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ncb2035","article-title":"A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases","volume":"12","author":"S Gastaldello","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1128\/JVI.00588-12","article-title":"Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates Pol{square} recruitment to DNA damage sites","volume":"86","author":"CB Whitehurst","year":"2012","journal-title":"J. Virol"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0092-8674(00)81056-9","article-title":"Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA","volume":"84","author":"A Bochkarev","year":"1996","journal-title":"Cell"},{"issue":"24","key":"ref41","doi-asserted-by":"crossref","first-page":"15323","DOI":"10.1128\/JVI.79.24.15323-15330.2005","article-title":"Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient","volume":"79","author":"MS Zeng","year":"2005","journal-title":"J Virol"},{"issue":"21","key":"ref42","doi-asserted-by":"crossref","first-page":"11291","DOI":"10.1128\/JVI.00823-11","article-title":"Direct sequencing and characterization of a clinical isolate of Epstein-Barr virus from nasopharyngeal carcinoma tissue by using next-generation sequencing technology","volume":"85","author":"P Liu","year":"2011","journal-title":"J Virol"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1128\/JVI.02020-12","article-title":"Epstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-\u03baB signaling during productive replication","volume":"87","author":"S Saito","year":"2013","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0130229","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0125420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T17:59:48Z","timestamp":1598983188000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0125420"}},"subtitle":[],"editor":[{"given":"Qiliang","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,1]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0125420","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0130229","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,1]]}}}