{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:09:20Z","timestamp":1759774160761},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0125807","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T18:02:03Z","timestamp":1431021723000},"page":"e0125807","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Local Application of Ibandronate\/Gelatin Sponge Improves Osteotomy Healing in Rabbits"],"prefix":"10.1371","volume":"10","author":[{"given":"Zongyou","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhidao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Peggrem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Triffitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-002276","article-title":"The relative incidence of fracture non-union in the Scottish population (5.17 million): a 5-year epidemiological study","volume":"3","author":"LA Mills","year":"2013","journal-title":"BMJ open"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11300","article-title":"Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review","volume":"11","author":"KR Garrison","year":"2007","journal-title":"Health technology assessment"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.injury.2013.08.003","article-title":"Fracture non-union: who is at risk?","volume":"44","author":"C Copuroglu","year":"2013","journal-title":"Injury"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s004020000252","article-title":"The influence of fracture etiology and type on fracture healing: a review of 104 consecutive tibial shaft fractures","volume":"121","author":"AH Karladani","year":"2001","journal-title":"Archives of orthopaedic and trauma surgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.injury.2011.04.003","article-title":"Predictive factors for functional outcome and failure in angular stable osteosynthesis of the proximal humerus","volume":"43","author":"F Hardeman","year":"2012","journal-title":"Injury"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.injury.2012.03.035","article-title":"Judet osteoperiosteal decortication for treatment of non-union: the Cornwall experience","volume":"43","author":"P Guyver","year":"2012","journal-title":"Injury"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.blo.0000163836.66906.74","article-title":"Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures","volume":"438","author":"L Audige","year":"2005","journal-title":"Clinical orthopaedics and related research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"SL Teitelbaum","year":"2000","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1359\/JBMR.050712","article-title":"Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. Journal of bone and mineral research: the official journal of the","volume":"20","author":"DG Little","year":"2005","journal-title":"American Society for Bone and Mineral Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1302\/0301-620X.89B4.18301","article-title":"The anabolic and catabolic responses in bone repair","volume":"89","author":"D Little","year":"2007","journal-title":"Journal of Bone & Joint Surgery, British Volume"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.orthres.2005.03.004","article-title":"A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair","volume":"23","author":"N Amanat","year":"2005","journal-title":"Journal of orthopaedic research: official publication of the Orthopaedic Research Society"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1359\/jbmr.070318","article-title":"Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair","volume":"22","author":"N Amanat","year":"2007","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa011807","article-title":"Intravenous zoledronic acid in postmenopausal women with low bone mineral density","volume":"346","author":"IR Reid","year":"2002","journal-title":"The New England journal of medicine"},{"issue":"Suppl 2","key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1081\/CNV-120014886","article-title":"The new bisphosphonate, Zometa (zoledronic acid), decreases skeletal complications in both osteolytic and osteoblastic lesions: a comparison to pamidronate","volume":"20","author":"A Lipton","year":"2002","journal-title":"Cancer investigation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-001-1135-6","article-title":"Medical management of hypercalcemia","volume":"74","author":"SH Ralston","year":"2004","journal-title":"Calcified tissue international"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1172\/JCI24281","article-title":"Paget disease of bone","volume":"115","author":"GD Roodman","year":"2005","journal-title":"The Journal of clinical investigation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","article-title":"Bisphosphonates: the first 40 years","volume":"49","author":"RG Russell","year":"2011","journal-title":"Bone"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/jbmr.5650091206","article-title":"Structural requirements for bisphosphonate actions in vitro","volume":"9","author":"E van Beek","year":"1994","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6222s","DOI":"10.1158\/1078-0432.CCR-06-0843","article-title":"Molecular mechanisms of action of bisphosphonates: current status","volume":"12","author":"AJ Roelofs","year":"2006","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00223-009-9323-x","article-title":"Gastric and esophagus events before and during treatment of osteoporosis","volume":"86","author":"P Vestergaard","year":"2010","journal-title":"Calcified tissue international"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2165\/00002018-200629120-00005","article-title":"Tolerability of different dosing regimens of bisphosphonates for the treatment of osteoporosis and malignant bone disease","volume":"29","author":"RS Bobba","year":"2006","journal-title":"Drug safety: an international journal of medical toxicology and drug experience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10157-008-0078-x","article-title":"Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a patient with focal segmental glomerulosclerosis","volume":"13","author":"N Miura","year":"2009","journal-title":"Clinical and experimental nephrology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4158\/EP.12.1.48","article-title":"Bisphosphonate-induced hypocalcemia: report of 3 cases and review of literature","volume":"12","author":"NM Maalouf","year":"2006","journal-title":"Endocrine practice: official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/cncr.11701","article-title":"Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial","volume":"98","author":"LS Rosen","year":"2003","journal-title":"Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00520-008-0553-7","article-title":"Risk of renal impairment after treatment with ibandronate versus zoledronic acid: a retrospective medical records review","volume":"17","author":"IJ Diel","year":"2009","journal-title":"Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1445-5994.2007.01580.x","article-title":"Risk factors for symptomatic hypocalcaemia complicating treatment with zoledronic acid","volume":"38","author":"S Chennuru","year":"2008","journal-title":"Internal medicine journal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJMc076132","article-title":"Alendronate and atrial fibrillation","volume":"356","author":"SR Cummings","year":"2007","journal-title":"The New England journal of medicine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"RE Marx","year":"2003","journal-title":"Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"SL Ruggiero","year":"2004","journal-title":"Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/1078155207080806","article-title":"Significance and impact of bisphosphonate-induced acute phase responses","volume":"13","author":"K Olson","year":"2007","journal-title":"Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners"},{"key":"ref31","first-page":"S53","article-title":"Use of a bisphosphonate (pamidronate) to modulate fracture repair in ovine bone","volume":"5","author":"AE Goodship","year":"1994","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology \/ ESMO"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/8756-3282(94)00035-X","article-title":"Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models","volume":"16","author":"Y Azuma","year":"1995","journal-title":"Bone"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/jor.1100140113","article-title":"Effect of alendronate on fracture healing and bone remodeling in dogs","volume":"14","author":"CP Peter","year":"1996","journal-title":"Journal of orthopaedic research: official publication of the Orthopaedic Research Society"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tripleo.2006.06.004","article-title":"Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management","volume":"102","author":"SL Ruggiero","year":"2006","journal-title":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1177\/0091270007301801","article-title":"Renal safety and pharmacokinetics of ibandronate in multiple myeloma patients with or without impaired renal function","volume":"47","author":"R Bergner","year":"2007","journal-title":"Journal of clinical pharmacology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10067-007-0824-6","article-title":"Monthly oral ibandronate is effective and well tolerated after 3 years: the MOBILE long-term extension","volume":"27","author":"JA Stakkestad","year":"2008","journal-title":"Clinical rheumatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10067-007-0827-3","article-title":"Persistence of weekly alendronate: a real-world study in Croatia","volume":"27","author":"S Grazio","year":"2008","journal-title":"Clinical rheumatology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00223-011-9563-4","article-title":"Effect of Dosing Interval Duration of Intermittent Ibandronate Treatment on the Healing Process of Femoral Osteotomy in a Rat Fracture Model","volume":"90","author":"T Manabe","year":"2012","journal-title":"Calcified tissue international"},{"key":"ref39","first-page":"2647","article-title":"Use of BMPs and bisphosphonates in improving bone fracture healing","volume":"4","author":"NY Yu","year":"2012","journal-title":"Frontiers in bioscience"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.22203\/eCM.v025a14","article-title":"Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation","volume":"25","author":"NY Yu","year":"2013","journal-title":"European cells & materials"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: The cellular picture","volume":"19","author":"A Schindeler","year":"2008","journal-title":"Seminars in cell & developmental biology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1172\/JCI115539","article-title":"Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure","volume":"88","author":"M Sato","year":"1991","journal-title":"The Journal of clinical investigation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jhsa.2008.12.011","article-title":"Comparison of radiographic fracture healing in the distal radius for patients on and off bisphosphonate therapy","volume":"34","author":"TD Rozental","year":"2009","journal-title":"The Journal of hand surgery"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0125807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:53:46Z","timestamp":1589036026000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0125807"}},"subtitle":[],"editor":[{"given":"James","family":"Cray","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0125807","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}