{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:19:03Z","timestamp":1790198343960,"version":"4.1.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0125980","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T18:08:25Z","timestamp":1431022105000},"page":"e0125980","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["A Post-Developmental Genetic Screen for Zebrafish Models of Inherited Liver Disease"],"prefix":"10.1371","volume":"10","author":[{"given":"Seok-Hyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-In","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Gamse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Ess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Hardiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua H.","family":"Lipschutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naji N.","family":"Abumrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don C.","family":"Rockey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/hep.23157","article-title":"New school in liver development: lessons from zebrafish","volume":"50","author":"J Chu","year":"2009","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4161\/cc.5.6.2550","article-title":"Modeling liver cancer using zebrafish: a comparative oncogenomics approach","volume":"5","author":"SH Lam","year":"2006","journal-title":"Cell Cycle"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1073\/pnas.1010210108","article-title":"The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish","volume":"108","author":"YU van der Velden","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/dmm.005587","article-title":"Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin","volume":"4","author":"SH Kim","year":"2011","journal-title":"Dis Model Mech"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/hep.24349","article-title":"Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish","volume":"54","author":"PC Thakur","year":"2011","journal-title":"Hepatology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1242\/dev.01918","article-title":"A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease","volume":"132","author":"KC Sadler","year":"2005","journal-title":"Development"},{"key":"ref7","first-page":"1","article-title":"Zebrafish issue of Development Development","volume":"123","author":"P Haffter","year":"1996"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1101\/gr.135541.111","article-title":"Mutation mapping and identification by whole-genome sequencing","volume":"22","author":"I Leshchiner","year":"2012","journal-title":"Genome Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1003563","DOI":"10.1371\/journal.pgen.1003563","article-title":"Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency","volume":"9","author":"SH Kim","year":"2013","journal-title":"PLoS Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jhep.2011.04.010","article-title":"NASH animal models: are we there yet","volume":"55","author":"R Kohli","year":"2011","journal-title":"J Hepatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-2001-12932","article-title":"Animal models of steatosis","volume":"21","author":"A Koteish","year":"2001","journal-title":"Semin Liver Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1440-1746.2008.05543.x","article-title":"Animal models of NASH: getting both pathology and metabolic context right","volume":"23","author":"CZ Larter","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000282097","article-title":"Animal models of non-alcoholic steatohepatitis: of mice and man","volume":"28","author":"JM Schattenberg","year":"2010","journal-title":"Dig Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/hep.27356","article-title":"Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting","volume":"60","author":"Q Gu","year":"2014","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/hep.27285","article-title":"Antagonistic interaction between Wnt and Notch activity modulates the regenerative capacity of a zebrafish fibrotic liver model","volume":"60","author":"M Huang","year":"2014","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/hep.27284","article-title":"Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition","volume":"60","author":"V Sapp","year":"2014","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1242\/dev.123.1.293","article-title":"Mutations affecting the cardiovascular system and other internal organs in zebrafish","volume":"123","author":"JN Chen","year":"1996","journal-title":"Development"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.123.1.1","article-title":"The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio","volume":"123","author":"P Haffter","year":"1996","journal-title":"Development"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1111\/cas.12025","article-title":"Novel roles of Vmp1: inhibition metastasis and proliferation of hepatocellular carcinoma","volume":"103","author":"L Guo","year":"2012","journal-title":"Cancer Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/srep01055","article-title":"The VMP1-Beclin 1 interaction regulates autophagy induction","volume":"3","author":"MI Molejon","year":"2013","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"120179","DOI":"10.1155\/2014\/120179","article-title":"Autophagy and non-alcoholic fatty liver disease","volume":"2014","author":"VJ Lavallard","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/MOH.0b013e3282f2bcce","article-title":"Chediak-Higashi syndrome","volume":"15","author":"J Kaplan","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/sj.jid.5700899","article-title":"Cellular defects in Chediak-Higashi syndrome correlate with the molecular genotype and clinical phenotype","volume":"127","author":"W Westbroek","year":"2007","journal-title":"J Invest Dermatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/S0140-6736(13)60020-3","article-title":"Chediak-Higashi syndrome: pathognomonic feature","volume":"382","author":"H Antunes","year":"2013","journal-title":"Lancet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nbt852","article-title":"Chemical discovery and global gene expression analysis in zebrafish","volume":"21","author":"FB Pichler","year":"2003","journal-title":"Nat Biotechnol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0125980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T13:13:04Z","timestamp":1651929184000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0125980"}},"subtitle":[],"editor":[{"given":"Zhiyuan","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0125980","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}