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Saito","year":"2002","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbrc.2007.05.197","article-title":"ATM phosphorylates ZBP-89 at Ser202 to potentiate p21(waf1) induction by butyrate","volume":"359","author":"L Bai","year":"2007","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"EP Rogakou","year":"1998","journal-title":"Journal of Biological Chemistry"},{"issue":"24","key":"ref46","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1158\/0008-5472.CAN-04-2727","article-title":"Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM","volume":"64","author":"I 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mediates its ability to repress activation of a viral lytic cycle late gene by Rta","volume":"78","author":"AS El-Guindy","year":"2004","journal-title":"Journal of Virology"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/JVI.47.1.193-201.1983","article-title":"Identification of polypeptide components of the Epstein-Barr virus early antigen complex with monoclonal antibodies","volume":"47","author":"GR Pearson","year":"1983","journal-title":"J Virol"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/JVI.01995-12","article-title":"Essential role of Rta in lytic DNA replication of Epstein-Barr virus","volume":"87","author":"A El-Guindy","year":"2013","journal-title":"Journal of Virology"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Philpott NJ, Turner AJ, Scopes J, Westby M, Marsh JC, Gordon-Smith EC, et al. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood. 1996(0006\u20134971 (Print)).","DOI":"10.1182\/blood.V87.6.2244.bloodjournal8762244"},{"issue":"11","key":"ref76","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1128\/JVI.02659-10","article-title":"Valproic Acid Antagonizes the Capacity of Other Histone Deacetylase Inhibitors To Activate the Epstein-Barr Virus Lytic Cycle","volume":"85","author":"D Daigle","year":"2011","journal-title":"Journal of Virology"},{"issue":"7","key":"ref77","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1128\/JVI.02445-06","article-title":"Phosphoacceptor site S173 in the regulatory domain of Epstein-Barr virus ZEBRA protein is required for lytic DNA replication but not for activation of viral early genes","volume":"81","author":"A El-Guindy","year":"2007","journal-title":"Journal of Virology"},{"issue":"2","key":"ref78","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1083\/jcb.97.2.562","article-title":"Visualization of longitudinally-oriented intermediate filaments in frozen sections of chicken cardiac muscle by a new staining method","volume":"97","author":"KT Tokuyasu","year":"1983","journal-title":"J Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0126088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T22:57:31Z","timestamp":1599001051000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0126088"}},"subtitle":[],"editor":[{"given":"Maria G.","family":"Masucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":78,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0126088","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]}}}