{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:14:29Z","timestamp":1790154869135,"version":"4.0.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0126206","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T17:52:56Z","timestamp":1431107576000},"page":"e0126206","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity"],"prefix":"10.1371","volume":"10","author":[{"given":"Michelle L.","family":"Parker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Boulanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"ref1","year":"2010"},{"issue":"12\u201313","key":"ref2","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"AM Tenter","year":"2000","journal-title":"Int J Parasitol"},{"issue":"3\u20134","key":"ref3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-4017(99)00076-X","article-title":"Important parasites in poultry production systems","volume":"84","author":"MD Ruff","year":"1999","journal-title":"Vet Parasitol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mib.2006.06.017","article-title":"Pulling together: an integrated model of Toxoplasma cell invasion","volume":"10","author":"V Carruthers","year":"2007","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1083\/jcb.77.1.72","article-title":"Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite","volume":"77","author":"M Aikawa","year":"1978","journal-title":"J Cell Biol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"e1001276","DOI":"10.1371\/journal.ppat.1001276","article-title":"The RON2-AMA1 interaction is a critical step in the moving-junction-dependent invasion by Apicomplexa parasites","volume":"7","author":"M Lamarque","year":"2011","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"e1001282","DOI":"10.1371\/journal.ppat.1001282","article-title":"The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex","volume":"7","author":"JS Tyler","year":"2011","journal-title":"PLoS Pathog"},{"issue":"32","key":"ref8","doi-asserted-by":"crossref","first-page":"13275","DOI":"10.1073\/pnas.1110303108","article-title":"Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion","volume":"108","author":"P Srinivasan","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ijpara.2014.08.001","article-title":"Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1","volume":"44","author":"KL Harvey","year":"2014","journal-title":"Int J Parasitol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"e1004670","DOI":"10.1371\/journal.ppat.1004670","article-title":"Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes","volume":"11","author":"GE Weiss","year":"2015","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"e1000309","DOI":"10.1371\/journal.ppat.1000309","article-title":"Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion","volume":"5","author":"S Besteiro","year":"2009","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"e1001276","DOI":"10.1371\/journal.ppat.1001276","article-title":"The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites","volume":"7","author":"M Lamarque","year":"2011","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"e29955","DOI":"10.1371\/journal.pone.0029955","article-title":"Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance","volume":"7","author":"HM Fritz","year":"2012","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1038\/ncomms5098","article-title":"Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites","volume":"5","author":"MH Lamarque","year":"2014","journal-title":"Nat Commun"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"e70637","DOI":"10.1371\/journal.pone.0070637","article-title":"Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1","volume":"8","author":"A Poukchanski","year":"2013","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"D553","DOI":"10.1093\/nar\/gkm981","article-title":"ToxoDB: an integrated Toxoplasma gondii database resource","volume":"36","author":"B Gajria","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/pro.2193","article-title":"Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion","volume":"22","author":"ML Tonkin","year":"2013","journal-title":"Protein Sci"},{"issue":"6041","key":"ref18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1126\/science.1204988","article-title":"Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide","volume":"333","author":"ML Tonkin","year":"2011","journal-title":"Science"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"e1002755","DOI":"10.1371\/journal.ppat.1002755","article-title":"Structural and functional insights into the malaria parasite moving junction complex","volume":"8","author":"B Vulliez-Le Normand","year":"2012","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1371\/journal.ppat.0030138","article-title":"Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody","volume":"3","author":"AM Coley","year":"2007","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"e1000273","DOI":"10.1371\/journal.ppat.1000273","article-title":"An inhibitory antibody blocks interactions between components of the malarial invasion machinery","volume":"5","author":"CR Collins","year":"2009","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"e1004273","DOI":"10.1371\/journal.ppat.1004273","article-title":"Host cell invasion by apicomplexan parasites: the junction conundrum","volume":"10","author":"D Bargieri","year":"2014","journal-title":"PLoS Pathog"},{"issue":"36","key":"ref23","doi-asserted-by":"crossref","first-page":"12736","DOI":"10.1073\/pnas.0501808102","article-title":"Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket","volume":"102","author":"T Bai","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"ref24","doi-asserted-by":"crossref","first-page":"15644","DOI":"10.1074\/jbc.M109.092619","article-title":"Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii","volume":"285","author":"J Crawford","year":"2010","journal-title":"J Biol Chem"},{"issue":"5720","key":"ref25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.1107449","article-title":"Crystal structure of the malaria vaccine candidate apical membrane antigen 1","volume":"308","author":"JC Pizarro","year":"2005","journal-title":"Science"},{"issue":"46","key":"ref26","doi-asserted-by":"crossref","first-page":"7310","DOI":"10.1021\/bi5012089","article-title":"Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO","volume":"53","author":"SS Lim","year":"2014","journal-title":"Biochemistry"},{"issue":"15","key":"ref27","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1021\/jm500390g","article-title":"Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR","volume":"57","author":"X Ge","year":"2014","journal-title":"J Med Chem"},{"key":"ref28","article-title":"Recent changes to the MOSFLM package for processing film and image plate data","volume":"26","author":"AGW Leslie","year":"1992","journal-title":"Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography"},{"issue":"Pt 1","key":"ref29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"P Evans","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"MD Winn","year":"2011","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"AJ McCoy","year":"2007","journal-title":"J Appl Crystallogr"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1107\/S0907444912001308","article-title":"Towards automated crystallographic structure refinement with phenix.refine","volume":"68","author":"PV Afonine","year":"2012","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"VB Chen","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"E Krissinel","year":"2007","journal-title":"J Mol Biol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"e1004539","DOI":"10.1371\/journal.ppat.1004539","article-title":"The shear stress of host cell invasion: exploring the role of biomolecular complexes","volume":"11","author":"ML Tonkin","year":"2015","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm.3073","article-title":"Malaria biology and disease pathogenesis: insights for new treatments","volume":"19","author":"LH Miller","year":"2013","journal-title":"Nat Med"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1517\/17460441.2012.729036","article-title":"Screening for small molecule inhibitors of Toxoplasma gondii","volume":"7","author":"S Kortagere","year":"2012","journal-title":"Expert opinion on drug discovery"},{"issue":"28","key":"ref39","doi-asserted-by":"crossref","first-page":"10311","DOI":"10.1073\/pnas.1409928111","article-title":"Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria","volume":"111","author":"P Srinivasan","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MOH.0000000000000135","article-title":"Host-parasite interactions that guide red blood cell invasion by malaria parasites","volume":"22","author":"AS Paul","year":"2015","journal-title":"Current opinion in hematology"},{"issue":"16","key":"ref41","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2174\/156802611796575885","article-title":"Apical membrane antigen 1 as an anti-malarial drug target","volume":"11","author":"CA Macraild","year":"2011","journal-title":"Current topics in medicinal chemistry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"642391","DOI":"10.1155\/2014\/642391","article-title":"Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1","volume":"2014","author":"A Alam","year":"2014","journal-title":"Malaria research and treatment"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1038\/ncomms3261","article-title":"Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion","volume":"4","author":"P Srinivasan","year":"2013","journal-title":"Nat Commun"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1071\/CH13266","article-title":"Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening","volume":"66","author":"SS Lim","year":"2013","journal-title":"Aust J Chem"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"e109674","DOI":"10.1371\/journal.pone.0109674","article-title":"Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide","volume":"9","author":"G Wang","year":"2014","journal-title":"PLoS One"},{"issue":"4\u20135","key":"ref46","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0264-410X(00)00185-7","article-title":"Plasmodium falciparum AMA-1 erythrocyte binding peptides implicate AMA-1 as erythrocyte binding protein","volume":"19","author":"M Urquiza","year":"2000","journal-title":"Vaccine"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-6851(01)00326-7","article-title":"Erythrocyte-binding activity of Plasmodium yoelii apical membrane antigen-1 expressed on the surface of transfected COS-7 cells","volume":"117","author":"TS Fraser","year":"2001","journal-title":"Mol Biochem Parasitol"},{"issue":"15","key":"ref48","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1073\/pnas.0501594102","article-title":"Domain III of Plasmodium falciparum apical membrane antigen 1 binds to the erythrocyte membrane protein Kx","volume":"102","author":"K Kato","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.biochi.2006.05.005","article-title":"Synthetic peptides from Plasmodium falciparum apical membrane antigen 1 (AMA-1) specifically interacting with human hepatocytes","volume":"88","author":"J Valbuena","year":"2006","journal-title":"Biochimie"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1128\/IAI.00969-08","article-title":"Babesia divergens apical membrane antigen 1 and its interaction with the human red blood cell","volume":"77","author":"E Montero","year":"2009","journal-title":"Infect Immun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/ncomms3552","article-title":"Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion","volume":"4","author":"DY Bargieri","year":"2013","journal-title":"Nat Commun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0126206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T19:59:12Z","timestamp":1566676752000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0126206"}},"subtitle":[],"editor":[{"given":"Ira J","family":"Blader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0126206","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}