{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:41:27Z","timestamp":1792856487463,"version":"4.5.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0126312","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T14:17:42Z","timestamp":1431094662000},"page":"e0126312","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":182,"title":["Gut Microbial Dysbiosis May Predict Diarrhea and Fatigue in Patients Undergoing Pelvic Cancer Radiotherapy: A Pilot Study"],"prefix":"10.1371","volume":"10","author":[{"given":"Aiping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxin","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel R.","family":"Kiela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinze","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1200\/JCO.2006.09.0001","article-title":"Patient assessment of bowel function during and after pelvic radiotherapy: results of a prospective phase III North Central Cancer Treatment Group clinical trial","volume":"25","author":"MG Haddock","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1067\/j.cpsurg.2013.04.004","article-title":"Gastrointestinal complications of pelvic radiotherapy: medical and surgical management strategies","volume":"50","author":"NM Hogan","year":"2013","journal-title":"Curr Probl Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1470-2045(10)70026-7","article-title":"Defining pelvic-radiation disease for the survivorship era","volume":"11","author":"HJ Andreyev","year":"2010","journal-title":"Lancet Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijnurstu.2004.07.008","article-title":"The experience of fatigue, other symptoms and global quality of life during radiotherapy for uterine cancer","volume":"42","author":"K Ahlberg","year":"2005","journal-title":"Int J Nurs Stud"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrgastro.2014.46","article-title":"Radiation enteropathy\u2014pathogenesis, treatment and prevention","volume":"11","author":"M Hauer-Jensen","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-277X.2005.00633.x","article-title":"A study to investigate women&apos;s experiences of radiation enteritis following radiotherapy for cervical cancer","volume":"18","author":"J Abayomi","year":"2005","journal-title":"J Hum Nutr Diet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1634\/theoncologist.2010-0097","article-title":"Exploring a link between fatigue and intestinal injury during pelvic radiotherapy","volume":"15","author":"S Jakobsson","year":"2010","journal-title":"Oncologist"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1634\/theoncologist.12-S1-22","article-title":"Mechanisms of cancer-related fatigue","volume":"1","author":"JL Ryan","year":"2007","journal-title":"Oncologist 12 Suppl"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"15490","DOI":"10.1523\/JNEUROSCI.3299-14.2014","article-title":"Gut microbes and the brain: paradigm shift in neuroscience","volume":"34","author":"EA Mayer","year":"2014","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1111\/j.1572-0241.2008.01868.x","article-title":"The gut microbiota predispose to the pathophysiology of acute postradiotherapy diarrhea","volume":"103","author":"C Manichanh","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anaerobe.2015.01.004","article-title":"High-throughput 16S rRNA gene sequencing reveals alterations of mouse intestinal microbiota after radiotherapy","volume":"33C","author":"YS Kim","year":"2015","journal-title":"Anaerobe"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13254","DOI":"10.1073\/pnas.0504830102","article-title":"Microbial regulation of intestinal radiosensitivity","volume":"102","author":"PA Crawford","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1111\/j.1572-0241.2002.05946.x","article-title":"Prevention of radiation-induced diarrhea with the use of VSL#3, a new high-potency probiotic preparation","volume":"97","author":"P Delia","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00042737-200104000-00015","article-title":"Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhoea","volume":"13","author":"H Urbancsek","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/S1470-2045(13)70504-7","article-title":"Microbiota and radiation-induced bowel toxicity: lessons from inflammatory bowel disease for the radiation oncologist","volume":"15","author":"MR Ferreira","year":"2014","journal-title":"Lancet Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbi.2006.11.004","article-title":"The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review","volume":"21","author":"C Schubert","year":"2007","journal-title":"Brain Behav Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0360-3016(99)00559-3","article-title":"Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy","volume":"47","author":"A Trotti","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/02841860601009430","article-title":"The psychometric properties of the Swedish Multidimensional Fatigue Inventory MFI-20 in four different populations","volume":"46","author":"CL Hagelin","year":"2007","journal-title":"Acta Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/1471-2164-14-390","article-title":"Pyrosequencing analysis of the human microbiota of healthy Chinese undergraduates","volume":"14","author":"Z Ling","year":"2013","journal-title":"BMC Genomics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"17994","DOI":"10.1073\/pnas.0807920105","article-title":"The influence of sex, handedness, and washing on the diversity of hand surface bacteria","volume":"105","author":"N Fierer","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1101\/gr.112730.110","article-title":"Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons","volume":"21","author":"BJ Haas","year":"2011","journal-title":"Genome Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","article-title":"SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB","volume":"35","author":"E Pruesse","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"PD Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/bioinformatics\/btq619","article-title":"NBC: the Naive Bayes Classification tool webserver for taxonomic classification of metagenomic reads","volume":"27","author":"GL Rosen","year":"2011","journal-title":"Bioinformatics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2105-7-371","article-title":"UniFrac\u2014an online tool for comparing microbial community diversity in a phylogenetic context","volume":"7","author":"C Lozupone","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1053\/gast.2000.20227","article-title":"Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans","volume":"119","author":"P Crenn","year":"2000","journal-title":"Gastroenterology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijrobp.2004.02.052","article-title":"Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients","volume":"60","author":"LC Lutgens","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00520-012-1648-8","article-title":"Assessment of patient-reported measures of bowel function before and after pelvic radiotherapy: an ancillary study of the North Central Cancer Treatment Group study N00CA","volume":"21","author":"PJ Atherton","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1365-2036.2008.03663.x","article-title":"Can biological markers act as non-invasive, sensitive indicators of radiation-induced effects in the gastrointestinal mucosa?","volume":"27","author":"L Wedlake","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/apt.12878","article-title":"Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis\u2014current evidence and potential clinical applications","volume":"40","author":"Y Touchefeu","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"K Atarashi","year":"2013","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mib.2013.06.003","article-title":"Faecalibacterium prausnitzii and human intestinal health","volume":"16","author":"S Miquel","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4292\/wjgpt.v6.i1.1","article-title":"Prevention of pelvic radiation disease","volume":"6","author":"L Fuccio","year":"2015","journal-title":"World J Gastrointest Pharmacol Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0126312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T17:44:34Z","timestamp":1717868674000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0126312"}},"subtitle":[],"editor":[{"given":"Sergei","family":"Grivennikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0126312","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}