{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:49:56Z","timestamp":1760906996836},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0126501","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T18:04:42Z","timestamp":1431540282000},"page":"e0126501","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Noninvasive Digital Detection of Fetal DNA in Plasma of 4-Week-Pregnant Women following In Vitro Fertilization and Embryo Transfer"],"prefix":"10.1371","volume":"10","author":[{"given":"Bedri","family":"Karakas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Qubbaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"Al-Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/nm.2829","article-title":"From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges","volume":"18","author":"DW Bianchi","year":"2011","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/pd.2574","article-title":"Prenatal Diagnosis: past, present, and future","volume":"30","author":"MA Ferguson-Smith","year":"2010","journal-title":"Prenat Diagn"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1025616019552","article-title":"The first prenatal diagnosis of a fetal abnormality","volume":"6","author":"RG Resta","year":"1997","journal-title":"J Genet Counsel"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1073\/pnas.76.3.1453","article-title":"Fetal cells in the blood of pregnant women: detection and enrichment by fluorescence-activated cell sorting","volume":"76","author":"LA Herzenberg","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"YMD Lo","year":"1997","journal-title":"The Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/clinchem\/46.11.1832","article-title":"Presence of fetal RNA in maternal plasma","volume":"46","author":"LLM Poon","year":"2000","journal-title":"Clin Chem"},{"issue":"15","key":"ref7","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1073\/pnas.1133470100","article-title":"Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations","volume":"100","author":"D Dressman","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nm.1789","article-title":"Circulating mutant DNA to assess tumor dynamics","volume":"14","author":"F Diehl","year":"2007","journal-title":"Nat Med"},{"issue":"13","key":"ref9","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJMe1301249","article-title":"Circulating Tumor DNA\u2014Ready for Prime Time?","volume":"368","author":"M Lippman","year":"2013","journal-title":"N Eng J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13116","DOI":"10.1073\/pnas.0705765104","article-title":"Digital PCR for the molecular detection of fetal chromosomal aneuploidy","volume":"104","author":"YMD Lo","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/pd.2150","article-title":"Digital PCR: a powerful new tool for noninvasive prenatal diagnosis?","volume":"28","author":"BG Zimmermann","year":"2008","journal-title":"Prenat Diagn"},{"key":"ref12","first-page":"241","article-title":"Les acides nucleiques du plasma sanguine chez I\u2019homme","volume":"142","author":"P Mandel","year":"1948","journal-title":"Comptes Rendus de l\u2019Acad\u00e9mie des Sciences"},{"key":"ref13","first-page":"646","article-title":"Free DNA in the serum of cancer patients and the effect of therapy","volume":"37","author":"SA Leon","year":"1977","journal-title":"Cancer Research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1200\/JCO.1999.17.2.578","article-title":"K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance","volume":"17","author":"A Castells","year":"1999","journal-title":"Journal of Clinical Oncology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.fertnstert.2013.02.012","article-title":"Cell-free fetal DNA and maternal serum analytes for monitoring embryonic and fetal status","volume":"99","author":"SL Simpson","year":"2013","journal-title":"Fertility and Sterility"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/clinchem\/45.2.184","article-title":"Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia","volume":"45","author":"Y Lo","year":"1999","journal-title":"Clinical Chemistry"},{"issue":"136","key":"ref17","doi-asserted-by":"crossref","first-page":"136ra68","DOI":"10.1126\/scitranslmed.3003726","article-title":"Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA","volume":"4","author":"T Forshew","year":"2012","journal-title":"Science Transl Med"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nbt0798-652","article-title":"Man-made cell-like compartments for molecular evolution","volume":"16","author":"DS Tawfik","year":"1998","journal-title":"Nature Biotechnology"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/humrep\/deg320","article-title":"Kinetics of SRY gene appearance in maternal serum: detection by real-time PCR in early pregnancy after assisted reproductive technique","volume":"18","author":"J Guibert","year":"2003","journal-title":"Human Reproduction"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nmeth898","article-title":"BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions","volume":"3","author":"F Diehl","year":"2006","journal-title":"Nat Meth"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/gim.2011.8","article-title":"Noninvasive fetal sex determination in maternal plasma: a prospective feasibility study","volume":"14","author":"FJ Fern\u00e1ndez-Mart\u00ednez","year":"2012","journal-title":"Genet Med"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1158\/1078-0432.CCR-11-2696","article-title":"Detection of tumor PIK3CA status in Metastatic Breast Cancer using Peripheral Blood","volume":"18","author":"MJ Higgins","year":"2012","journal-title":"Clin Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0126501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T04:35:18Z","timestamp":1599021318000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0126501"}},"subtitle":[],"editor":[{"given":"Meni","family":"Wanunu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0126501","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}