{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:55:58Z","timestamp":1791255358764,"version":"4.1.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0126803","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T18:29:18Z","timestamp":1432924158000},"page":"e0126803","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Yang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Side","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"NA Molodecky","year":"2012","journal-title":"Gastroenterology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nri2340","article-title":"The genetics and immunopathogenesis of inflammatory bowel disease","volume":"8","author":"JH Cho","year":"2008","journal-title":"Nature reviews Immunology"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0016-5085(84)80014-1","article-title":"Familial incidence of Crohn's disease in The Netherlands and a review of the literature","volume":"86","author":"IT Weterman","year":"1984","journal-title":"Gastroenterology"},{"issue":"42","key":"ref4","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.3748\/wjg.v13.i42.5560","article-title":"Novel genetic markers in inflammatory bowel disease","volume":"13","author":"L Rodriguez-Bores","year":"2007","journal-title":"World journal of gastroenterology: WJG"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1046\/j.1398-9995.2003.00225.x","article-title":"Toll-like receptors: sensors of the innate immune system","volume":"58","author":"M Seitz","year":"2003","journal-title":"Allergy"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll","volume":"95","author":"FL Rock","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","volume":"11","author":"O Takeuchi","year":"1999","journal-title":"Immunity"},{"issue":"6797","key":"ref8","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/35021228","article-title":"Toll-like receptors in the induction of the innate immune response","volume":"406","author":"A Aderem","year":"2000","journal-title":"Nature"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"G514","DOI":"10.1152\/ajpgi.00377.2004","article-title":"Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis","volume":"288","author":"JC Singh","year":"2005","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1128\/IAI.68.12.7010-7017.2000","article-title":"Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease","volume":"68","author":"E Cario","year":"2000","journal-title":"Infection and immunity"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1084\/jem.20022078","article-title":"Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling","volume":"197","author":"C Erridge","year":"2003","journal-title":"The Journal of experimental medicine"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1053\/gast.2002.33662","article-title":"Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation","volume":"122","author":"M Hausmann","year":"2002","journal-title":"Gastroenterology"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"GR Abecasis","year":"2002","journal-title":"Nature genetics"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1359\/JBMR.0301265","article-title":"Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study","volume":"19","author":"A Thakkinstian","year":"2004","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"issue":"7414","key":"ref15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"BMJ (Clinical research ed)"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/biostatistics\/kxs006","article-title":"A valid formulation of the analysis of noninferiority trials under random effects meta-analysis","volume":"13","author":"EH Brittain","year":"2012","journal-title":"Biostatistics (Oxford, England)"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/sim.4143","article-title":"Meta-analysis and sensitivity analysis for multi-arm trials with selection bias","volume":"30","author":"H Chootrakool","year":"2011","journal-title":"Statistics in medicine"},{"issue":"1","key":"ref18","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"R Siegel","year":"2012","journal-title":"CA: a cancer journal for clinicians"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.psychres.2004.06.011","article-title":"Assessing publication bias in genetic association studies: evidence from a recent meta-analysis","volume":"129","author":"MR Munafo","year":"2004","journal-title":"Psychiatry research"},{"issue":"7129","key":"ref20","first-page":"471","article-title":"Bias in meta-analysis detected by a simple, graphical test. Increase in studies of publication bias coincided with increasing use of meta-analysis","volume":"316","author":"F Song","year":"1998","journal-title":"BMJ (Clinical research ed)"},{"issue":"7109","key":"ref21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ (Clinical research ed)"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"S Duval","year":"2000","journal-title":"Biometrics"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jcla.2075","article-title":"Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness","volume":"16","author":"N Okayama","year":"2002","journal-title":"Journal of clinical laboratory analysis"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.gene.6364111","article-title":"NOD2\/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?","volume":"5","author":"ID Arnott","year":"2004","journal-title":"Genes and immunity"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1136\/gut.2003.030205","article-title":"Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis","volume":"53","author":"D Franchimont","year":"2004","journal-title":"Gut"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/01.MIB.0000168372.94907.d2","article-title":"The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15\/NOD2 mutations in the susceptibility and phenotype of Crohn's disease","volume":"11","author":"S Brand","year":"2005","journal-title":"Inflammatory bowel diseases"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1111\/j.1572-0241.2005.00325.x","article-title":"Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy","volume":"100","author":"W Fries","year":"2005","journal-title":"The American journal of gastroenterology"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3748\/wjg.v11.i5.681","article-title":"Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15\/NOD2 and inflammatory bowel disease in the Greek population","volume":"11","author":"M Gazouli","year":"2005","journal-title":"World journal of gastroenterology: WJG"},{"issue":"3","key":"ref29","first-page":"439","article-title":"The toll-like receptor 4 (TLR4) Asp299Gly polymorphism is associated with colonic localisation of Crohn's disease without a major role for the Saccharomyces cerevisiae mannan-LBP-CD14-TLR4 pathway","volume":"54","author":"S Ouburg","year":"2005","journal-title":"Gut"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clim.2004.03.002","article-title":"Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis","volume":"112","author":"HP Torok","year":"2004","journal-title":"Clinical immunology (Orlando, Fla)"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00109-005-0685-x","article-title":"Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients","volume":"83","author":"H Braat","year":"2005","journal-title":"Journal of molecular medicine (Berlin, Germany)"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/01.MIB.0000161305.81198.0f","article-title":"Association between Toll-like receptor 4 and inflammatory bowel disease","volume":"11","author":"LE Oostenbrug","year":"2005","journal-title":"Inflammatory bowel diseases"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3748\/wjg.v11.i10.1489","article-title":"Toll-like receptor 4 and NOD2\/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations","volume":"11","author":"PL Lakatos","year":"2005","journal-title":"World journal of gastroenterology: WJG"},{"issue":"2","key":"ref34","first-page":"125","article-title":"NOD2\/CARD15 and Toll-like 4 receptor gene polymorphism in Chilean patients with inflammatory bowel disease","volume":"17","author":"C Figueroa","year":"2006","journal-title":"European cytokine network"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.MIB.0000195389.11645.ab","article-title":"Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases","volume":"12","author":"M Pierik","year":"2006","journal-title":"Inflammatory bowel diseases"},{"issue":"2","key":"ref36","first-page":"212","article-title":"No association of TLR4 gene Asp299Gly, TLR2 gene Arg753Glu and Arg677Trp polymorphisms with inflammatiory bowel disease in Chinese Han Population of Hubei Province(Chinese)","volume":"14","author":"F Xiong L-","year":"2006","journal-title":"World Chinese Journal of Digestology"},{"issue":"7","key":"ref37","first-page":"585","article-title":"The association between Toll-like receptor-4 gene Asp299Gly polymorphism and ulcerativecolitis and colorectal adenocarcinoma(Chinese)","volume":"45","author":"YM Yi Jiang X-","year":"2006","journal-title":"Chin J Intern"},{"issue":"10","key":"ref38","first-page":"1226","article-title":"Gene polymorphisms of Toll like receptors in inflammatory bowel disease and their distributionin different populations(Chinese)","volume":"27","author":"Xue P-HN Hui-Ping","year":"2007","journal-title":"Journal of Shanghai Jiaotong University(Medical Science)"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1136\/gut.2007.125468","article-title":"Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease","volume":"56","author":"L Henckaerts","year":"2007","journal-title":"Gut"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1440-1746.2006.04727.x","article-title":"TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort","volume":"22","author":"J Hong","year":"2007","journal-title":"Journal of gastroenterology and hepatology"},{"issue":"3\u20134","key":"ref41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000112646","article-title":"The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease","volume":"76","author":"DC Baumgart","year":"2007","journal-title":"Digestion"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1111\/j.1572-0241.2007.01463.x","article-title":"Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association","volume":"102","author":"BL Browning","year":"2007","journal-title":"The American journal of gastroenterology"},{"issue":"28","key":"ref43","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.3748\/wjg.14.4454","article-title":"Clinical significance of NOD2\/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease","volume":"14","author":"L Rigoli","year":"2008","journal-title":"World journal of gastroenterology: WJG"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ibd.20362","article-title":"Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population","volume":"14","author":"GE Hume","year":"2008","journal-title":"Inflammatory bowel diseases"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"A465","DOI":"10.1016\/S0016-5085(08)62175-7","article-title":"Association between Toll-like 4, cd14 polymorphisms and inflammatory bowel disease in Turkish population","volume":"134","author":"H Akin","year":"2008","journal-title":"Gastroenterology"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/ibd.20431","article-title":"Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population","volume":"14","author":"M Lappalainen","year":"2008","journal-title":"Inflammatory bowel diseases"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4166\/kjg.2009.54.6.377","article-title":"[Association of Toll-like receptor gene with Crohn's disease in Koreans]","volume":"54","author":"BD Ye","year":"2009","journal-title":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-230X-9-62","article-title":"Tolllike receptor 4 (TLR4) polymorphisms in Tunisian patients with Crohn's disease: genotype-phenotype correlation","volume":"9","author":"L Zouiten-Mekki","year":"2009","journal-title":"BMC gastroenterology"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ibd.20757","article-title":"Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis","volume":"15","author":"DM Queiroz","year":"2009","journal-title":"Inflammatory bowel diseases"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00431-008-0798-7","article-title":"Clustering of (auto)immune diseases with early-onset and complicated inflammatory bowel disease","volume":"168","author":"M Bueno de Mesquita","year":"2009","journal-title":"European journal of pediatrics"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"e15376","DOI":"10.1371\/journal.pone.0015376","article-title":"Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort","volume":"5","author":"J Wagner","year":"2010","journal-title":"PloS one"},{"issue":"20","key":"ref52","first-page":"1416","article-title":"Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations","volume":"90","author":"XY Shen","year":"2010","journal-title":"Zhonghua yi xue za zhi"},{"key":"ref53","author":"L Chen","year":"2011"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.humimm.2011.12.006","article-title":"Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis","volume":"73","author":"G Sivaram","year":"2012","journal-title":"Human immunology"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.3390\/ijms13044268","article-title":"CARD15\/NOD2, CD14 and toll-like 4 receptor gene polymorphisms in Saudi patients with Crohn's Disease","volume":"13","author":"N Azzam","year":"2012","journal-title":"International journal of molecular sciences"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3346\/jkms.2012.27.1.72","article-title":"Association between toll-like receptors\/CD14 gene polymorphisms and inflammatory bowel disease in Korean population","volume":"27","author":"EJ Kim","year":"2012","journal-title":"Journal of Korean medical science"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.dld.2012.03.024","article-title":"CARD15 and Toll-like receptor 4 mutations in Italian patients with inflammatory bowel disease","volume":"44","author":"D Guagnozzi","year":"2012","journal-title":"Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver"},{"issue":"2","key":"ref58","first-page":"371","article-title":"Readressing the role of Toll-like receptor-4 alleles in inflammatory bowel disease: colitis, smoking, and seroreactivity","volume":"58","author":"AC Manolakis","year":"2013","journal-title":"Digestive diseases and sciences"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tig.2009.01.001","article-title":"GWA studies: rewriting the story of IBD","volume":"25","author":"ML Budarf","year":"2009","journal-title":"Trends in genetics: TIG"},{"issue":"7422","key":"ref60","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"L Jostins","year":"2012","journal-title":"Nature"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/gutjnl-2013-305193","article-title":"Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations","volume":"63","author":"SK Yang","year":"2014","journal-title":"Gut"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2011.02.046","article-title":"Recent insights into the genetics of inflammatory bowel disease","volume":"140","author":"JH Cho","year":"2011","journal-title":"Gastroenterology"},{"issue":"10","key":"ref63","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1097\/MIB.0000000000000174","article-title":"Immuno-genomic profiling of patients with inflammatory bowel disease: a systematic review of genetic and functional in vivo studies of implicated genes","volume":"20","author":"T Coelho","year":"2014","journal-title":"Inflammatory bowel diseases"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrg2203","article-title":"New links to the pathogenesis of Crohn disease provided by genome-wide association scans","volume":"9","author":"CG Mathew","year":"2008","journal-title":"Nature reviews Genetics"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/ibd.21845","article-title":"Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis","volume":"18","author":"SC Ng","year":"2012","journal-title":"Inflammatory bowel diseases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0126803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T02:35:46Z","timestamp":1652150146000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0126803"}},"subtitle":[],"editor":[{"given":"David L","family":"Boone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,29]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0126803","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,29]]}}}