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Nephrol Dial Transplant. 2013. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1093\/ndt\/gfs590.\" xlink:type=\"simple\">10.1093\/ndt\/gfs590.<\/ext-link><\/comment> PubMed <object-id pub-id-type=\"pmid\">23355629<\/object-id>.","DOI":"10.1093\/ndt\/gfs590"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2215\/CJN.07831109","article-title":"Cardiovascular effects of angiotensin converting enzyme inhibition or angiotensin receptor blockade in hemodialysis: a meta-analysis","volume":"5","author":"D Tai","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MAJ.0b013e318249d387","article-title":"Angiotensin receptor blockers reduce left ventricular hypertrophy in dialysis patients: a meta-analysis","volume":"345","author":"LY Yang","year":"2013","journal-title":"Am J Med Sci"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0002-9343(01)01068-3","article-title":"Renin-angiotensin system blockade and the risk of hyperkalemia in chronic hemodialysis patients","volume":"112","author":"GA Knoll","year":"2002","journal-title":"Am J Med"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/ndt\/gft515","article-title":"Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial","volume":"29","author":"R Agarwal","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"ref25","first-page":"A4602","article-title":"Renal and cardiovascular effects of irbesartan in dialysis patients\u2014a randomized controlled trial protocol (SAFIR study)","volume":"60","author":"CD Peters","year":"2013","journal-title":"Dan Med J"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ki.2014.69","article-title":"No significant effect of angiotensin II receptor blockade on intermediate cardiovascular end points in hemodialysis patients","volume":"86","author":"CD Peters","year":"2014","journal-title":"Kidney Int"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Kjaergaard KD, Peters CD, Jespersen B, Tietze IN, Madsen JK, Pedersen BB, et al. 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Sherman","year":"1990","journal-title":"ASAIO Trans"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"c65","DOI":"10.1159\/000139991","article-title":"Blood pressure control and symptomatic intradialytic hypotension in diabetic haemodialysis patients: a cross-sectional survey","volume":"109","author":"A Davenport","year":"2008","journal-title":"Nephron Clin Pract"},{"issue":"6210","key":"ref44","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/bmj.280.6210.288","article-title":"Effects of an angiotensin-converting enzyme inhibitor (captopril) on blood pressure in anephric subjects","volume":"280","author":"Veld AJ Man in 't","year":"1980","journal-title":"Br Med J"},{"issue":"Suppl 2","key":"ref45","first-page":"ii22","article-title":"EBPG guideline on haemodynamic instability","volume":"22","author":"J Kooman","year":"2007","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"ref46","first-page":"425","article-title":"Efficacy, safety and 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