{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:40:48Z","timestamp":1793122848696,"version":"4.5.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0127109","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T18:10:06Z","timestamp":1432663806000},"page":"e0127109","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues"],"prefix":"10.1371","volume":"10","author":[{"given":"Sureewan","family":"Bumrungthai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tipaya","family":"Ekalaksananan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Francis","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peechanika","family":"Chopjitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thumwadee","family":"Tangsiriwatthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natcha","family":"Patarapadungkit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilaiwan","family":"Kleebkaow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanguanchoke","family":"Luanratanakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunkerd","family":"Kongyingyoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchin","family":"Worawichawong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamsai","family":"Pientong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000214918","article-title":"Molecular mechanisms of human papillomavirus-induced carcinogenesis","volume":"12","author":"M Lehoux","year":"2009","journal-title":"Public Health Genomics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2886","article-title":"Human papillomavirus oncoproteins: pathways to transformation","volume":"10","author":"CA Moody","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.3892\/or.2014.3142","article-title":"Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)","volume":"31","author":"H Jim\u00e9nez-Wences","year":"2014","journal-title":"Oncol Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.4161\/cc.7.16.6453","article-title":"microRNAs and cancer: an overview","volume":"7","author":"PP Medina","year":"2008","journal-title":"Cell Cycle"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1158\/1078-0432.CCR-07-1231","article-title":"Altered MicroRNA expression in cervical carcinomas","volume":"14","author":"JW Lee","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1007\/s12032-011-9830-2","article-title":"Aberrant microRNA expression in human cervical carcinomas","volume":"29","author":"Q Rao","year":"2012","journal-title":"Med Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbrc.2009.08.044","article-title":"MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells","volume":"388","author":"Q Yao","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e2557","DOI":"10.1371\/journal.pone.0002557","article-title":"Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth","volume":"3","author":"X Wang","year":"2008","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1158\/0008-5472.CAN-06-0561","article-title":"Patterns of known and novel small RNAs in human cervical cancer","volume":"67","author":"WO Lui","year":"2007","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ygyno.2012.12.043","article-title":"MicroRNA-182 plays an onco-miRNA role in cervical cancer","volume":"129","author":"T Tang","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1261\/rna.1442309","article-title":"Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6","volume":"15","author":"X Wang","year":"2009","journal-title":"RNA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/onc.2010.613","article-title":"Human papillomavirus type 16 E6 Induces cervical cancer cell migration through the p53\/microRNA-23b\/urokinase-type plasminogen activator pathway","volume":"30","author":"CL Au Yeung","year":"2011","journal-title":"Oncogene"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ygyno.2011.03.032","article-title":"Polymorphism of the pre-<italic>miR-146a<\/italic> is associated with risk of cervical cancer in a Chinese population","volume":"122","author":"C Yue","year":"2011","journal-title":"Gynecol Oncol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10585-010-9355-7","article-title":"High levels of <italic>microRNA-21<\/italic> in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients","volume":"28","author":"BS Nielsen","year":"2011","journal-title":"Clin Exp Metastasis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e10630","DOI":"10.1371\/journal.pone.0010630","article-title":"Identification of <italic>microRNA-21<\/italic> as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer","volume":"5","author":"JH Hwang","year":"2011","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1476-4598-9-12","article-title":"<italic>miR-21<\/italic>: an oncomir on strike in prostate cancer","volume":"9","author":"M Folini","year":"2010","journal-title":"Mol Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1476-4598-9-238","article-title":"Programmed cell death 4 loss increases tumor cell invasion and is regulated by <italic>miR-21<\/italic> in oral squamous cell carcinoma","volume":"9","author":"PP Reis","year":"2010","journal-title":"Mol Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ygyno.2014.01.034","article-title":"The inhibition of <italic>miR-21<\/italic> promotes apoptosis and chemosensitivity in ovarian cancer","volume":"132","author":"JK Chan","year":"2014","journal-title":"Gynecol Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e28423","DOI":"10.1371\/journal.pone.0028423","article-title":"Expression of <italic>mir-21<\/italic> and <italic>mir-143<\/italic> in cervical specimens ranging from histologically normal through to invasive cervical cancer","volume":"6","author":"G Deftereos","year":"2011","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molcel.2010.07.023","article-title":"STAT3 activation of <italic>miR-21<\/italic> and <italic>miR-181b-1<\/italic> via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer","volume":"39","author":"D Iliopoulos","year":"2010","journal-title":"Mol Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1016\/j.ejca.2013.07.140","article-title":"Activation of interleukin-6\/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment","volume":"49","author":"C Ren","year":"2013","journal-title":"Eur J Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1158\/0008-5472.CAN-09-1996","article-title":"<italic>microRNA-21<\/italic> negatively regulates Cdc25A and cell cycle progression in colon cancer cells","volume":"69","author":"P Wang","year":"2009","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1158\/0008-5472.CAN-07-5714","article-title":"Cancer-associated stromal fibroblasts promote pancreatic tumor progression","volume":"68","author":"RF Hwang","year":"2008","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","article-title":"Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion","volume":"121","author":"A Orimo","year":"2005","journal-title":"Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/ijc.25506","article-title":"<italic>Micro-RNA-21<\/italic> regulates TGF-\u03b2-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction","volume":"128","author":"Q Yao","year":"2011","journal-title":"Int J Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e60914","DOI":"10.1371\/journal.pone.0060914","article-title":"Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis","volume":"8","author":"H Kinoshita","year":"2013","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/gyno.2001.6235","article-title":"Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor","volume":"82","author":"LH Wei","year":"2001","journal-title":"Gynecol Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/gyno.1999.5358","article-title":"Increased IL-6 and IL-8 levels in cervicovaginal secretions of patients with cervical cancer","volume":"73","author":"MY Tjiong","year":"1999","journal-title":"Gynecol Oncol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1006\/viro.1999.9722","article-title":"Response to IL-6 of HPV-18 cervical carcinoma cell lines","volume":"258","author":"T Bauknecht","year":"1999","journal-title":"Virology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/gyno.2000.5904","article-title":"A case of cervical cancer with aggressive tumor growth: possible autocrine growth stimulation by G-CSF and Il-6","volume":"78","author":"S Kyo","year":"2000","journal-title":"Gynecol Oncol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/bjc.1997.152","article-title":"Interleukin 1alpha and interleukin 6 promote the in vitro growth of both normal and neoplastic human cervical epithelial cells","volume":"75","author":"G Castrilli","year":"1997","journal-title":"Br J Cancer"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/sj.onc.1206226","article-title":"Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway","volume":"22","author":"LH Wei","year":"2003","journal-title":"Oncogene"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.intimp.2012.01.014","article-title":"Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells","volume":"12","author":"SI Abdelwahab","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"ref34","first-page":"6243","article-title":"Analysis of interleukin 6 gene expression in cervical neoplasia using a quantitative polymerase chain reaction assay: evidence for enhanced interleukin 6 gene expression in invasive carcinoma","volume":"54","author":"E Tartour","year":"1994","journal-title":"Cancer Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1099\/0022-1317-76-4-1057","article-title":"The use of general primers GP5 and GP6 elongated at their 3&apos; ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR","volume":"76","author":"AM de Roda Husman","year":"1995","journal-title":"J Gen Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/clinchem\/46.7.1000","article-title":"Genotyping of HLA-B27 by real-time PCR without hybridization probes","volume":"46","author":"MA Bon","year":"2000","journal-title":"Clin Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/carcin\/bgr213","article-title":"MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4","volume":"32","author":"X Liu","year":"2011","journal-title":"Carcinogenesis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1369\/0022155410397995","article-title":"Cellular expression and localization of estrogen receptor \u03b1 and progesterone receptor mRNA in the bovine oviduct combining laser-assisted microdissection, quantitative PCR, and in situ hybridization","volume":"59","author":"RA Kenngott","year":"2011","journal-title":"J Histochem Cytochem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/002215549804600611","article-title":"Rapid synthesis of biotin-, digoxigenin-, trinitrophenyl-, and fluorochrome-labeled tyramides and their application for in situ hybridization using CARD amplification","volume":"46","author":"AH Hopman","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","article-title":"<italic>MicroRNA-21<\/italic> (<italic>miR-21<\/italic>) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer","volume":"27","author":"IA Asangani","year":"2008","journal-title":"Oncogene"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ni.1828","article-title":"Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA <italic>miR-21<\/italic>","volume":"11","author":"FJ Sheedy","year":"2010","journal-title":"Nat Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.onc.1204137","article-title":"A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation","volume":"20","author":"HS Yang","year":"2001","journal-title":"Oncogene"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e57652","DOI":"10.1371\/journal.pone.0057652","article-title":"Feedback regulations of <italic>miR-21<\/italic> and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation","volume":"8","author":"L Shen","year":"2013","journal-title":"PLoS One"},{"key":"ref44","first-page":"944","article-title":"Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro","volume":"146","author":"M Iglesias","year":"1995","journal-title":"Am J Pathol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0127109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T17:21:34Z","timestamp":1599067294000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0127109"}},"subtitle":[],"editor":[{"given":"Annie NY","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,26]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0127109","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,26]]}}}