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Prevalence and characteristics of ESBL-producing E. coli in Dutch recreational waters influenced by wastewater treatment plants. 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NEN-EN-ISO 19458. Water quality\u2014Sampling for microbiological analysis.2007."},{"key":"ref31","unstructured":"Anonymous. NEN-EN-ISO 9308\u20131 Water\u2014Detectie en enumeratie van <italic>Escherichia coli<\/italic> en bacteri\u00ebn van de coligroep\u2014Deel 1: Methode met membraanfiltratie. 2000."},{"key":"ref32","unstructured":"Anonymous. ISO 16649\u20132 Microbiology of food and animal feeding stuffs\u2014Horizontal method for the enumeration of beta-glucuronidase-positive <italic>Escherichia coli\u2014<\/italic>part 2: Colony count technique at 44\u00b0C using 5-bromo-4-chloro-3-indolyl beta-D-glucuronide. 2001."},{"key":"ref33","year":"2010"},{"key":"ref34","unstructured":"EUCAST.2014. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eucast.org\/\" xlink:type=\"simple\">http:\/\/www.eucast.org\/<\/ext-link>. Accessed February 2015."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"AP Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref36","unstructured":"MARAN. Monitoring of antimicrobial resistance and antibiotic usage in animals in the Netherlands in 2010\/2011. 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.wageningenur.nl\/nl\/Expertises-Dienstverlening\/Onderzoeksinstituten\/Central-Veterinary-Institute\/Publicaties-CVI\/MARAN-Rapporten.htm\" xlink:type=\"simple\">http:\/\/www.wageningenur.nl\/nl\/Expertises-Dienstverlening\/Onderzoeksinstituten\/Central-Veterinary-Institute\/Publicaties-CVI\/MARAN-Rapporten.htm<\/ext-link>."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CMR.00036-08","article-title":"AmpC \u00df-lactamases","volume":"22","author":"GA Jacoby","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jac\/dkp498","article-title":"Development of a set of multiplex PCR assays for the detection of genes encoding important \u03b2-lactamases in Enterobacteriaceae","volume":"65","author":"C Dallenne","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1128\/AEM.66.10.4555-4558.2000","article-title":"Rapid and simple determination of the <italic>Escherichia coli<\/italic> phylogenetic group","volume":"66","author":"O Clermont","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1111\/j.1462-2920.2006.01077.x","article-title":"Identification of forces shaping the commensal <italic>Escherichia coli<\/italic> genetic structure by comparing animal and human isolates","volume":"8","author":"P Escobar-P\u00e1ramo","year":"2006","journal-title":"Environ Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1365-2958.2006.05172.x","article-title":"Sex and virulence in <italic>Escherichia coli<\/italic>: an evolutionary perspective","volume":"60","author":"T Wirth","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1017\/S0950268811002676","article-title":"Source attribution of human campylobacteriosis using a meta-analysis of case-control studies of sporadic infections","volume":"140","author":"AR Domingues","year":"2012","journal-title":"Epidemiol Infect"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S0950268811002172","article-title":"Source attribution of human salmonellosis using a meta-analysis of case-control studies of sporadic infections","volume":"140","author":"AR Domingues","year":"2012","journal-title":"Epidemiol Infect"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1504\/IJRAM.2008.016151","article-title":"Campylobacter source attribution by exposure assessment","volume":"8","author":"EG Evers","year":"2008","journal-title":"Int J Risk Assessment and Managment"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3201\/eid1104.040739","article-title":"Epidemiology of <italic>Escherichia coli<\/italic> O157:H7 outbreaks, United States, 1982\u20132002","volume":"11","author":"JM Rangel","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10408410802357432","article-title":"Ecology of <italic>E<\/italic>. <italic>coli<\/italic> O157:H7 and <italic>Salmonella enterica<\/italic> in the primary vegetable production chain","volume":"34","author":"E Franz","year":"2008","journal-title":"Crit Rev Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/AEM.68.1.397-400.2002","article-title":"Transmission of <italic>Escherichia coli<\/italic> O157:H7 from contaminated manure and irrigation water to lettuce plant tissue and its subsequent internalization","volume":"68","author":"EB 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quantitative microbial risk assessment from surface water to potable water","volume":"45","author":"JF Schijven","year":"2011","journal-title":"Water Res"},{"key":"ref52","unstructured":"NETHMAP. Consumption of antimicrobial agents and antimicrobial resistance among medically important bacteria in the Netherlands. 2013. 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