{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:56:03Z","timestamp":1780433763277,"version":"3.54.1"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128028","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T13:54:46Z","timestamp":1432216486000},"page":"e0128028","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia"],"prefix":"10.1371","volume":"10","author":[{"given":"Henna","family":"Shaikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Boudes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Khoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shevell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Wintermark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"P Carmeliet","year":"2003","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia","volume":"111","author":"Y Sun","year":"2003","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"L Wang","year":"2004","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1172\/JCI200420622","article-title":"Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model","volume":"114","author":"A Taguchi","year":"2004","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1161\/01.STR.25.9.1794","article-title":"Role of angiogenesis in patients with cerebral ischemic stroke","volume":"25","author":"J Krupinski","year":"1994","journal-title":"Stroke"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/08830738010160110201","article-title":"Long-term developmental outcome of asphyxiated term neonates","volume":"16","author":"ME Dilenge","year":"2001","journal-title":"J Child Neurol"},{"key":"ref7","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic-ischemic encephalopathy","volume":"1","author":"SE Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis","volume":"166","author":"MA Tagin","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"ref9","first-page":"298","article-title":"Angiogenesis, neurogenesis and brain recovery of function following injury","volume":"11","author":"Y Xiong","year":"2010","journal-title":"Curr Opin Investig Drugs"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia","volume":"13","author":"MA Yenari","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/jnc.12110","article-title":"Enhanced expression of the Flt-1 and Flk-1 receptor tyrosine kinases in a newborn piglet model of ischemic tolerance","volume":"124","author":"J Ara","year":"2013","journal-title":"J Neurochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00401-008-0339-5","article-title":"The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1 alpha in the developing rat brain after hypoxia-ischemia","volume":"115","author":"L Li","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainres.2007.12.059","article-title":"The involvement of phosphoinositid 3-kinase\/Akt pathway in the activation of hypoxia-inducible factor-1alpha in the developing rat brain after hypoxia-ischemia","volume":"1197","author":"L Li","year":"2008","journal-title":"Brain Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2007.08.059","article-title":"Relationship between HIF-1alpha expression and neuronal apoptosis in neonatal rats with hypoxia-ischemia brain injury","volume":"1180","author":"L Li","year":"2007","journal-title":"Brain Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.nbd.2003.08.020","article-title":"Regulation of hypoxia-inducible factor 1\u03b1 and induction of vascular endothelial growth factor in a rat neonatal stroke model","volume":"14","author":"D Mu","year":"2003","journal-title":"Neurobiol Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"PD Gluckman","year":"2005","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"National Institute of Child Health and Human Development Neonatal Research Network. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"S Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"DV Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.AOG.0000445580.65983.d2","article-title":"Executive summary: Neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Neonatal Encephalopathy","volume":"123","year":"2014","journal-title":"Obstet Gynecol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1482","DOI":"10.1542\/peds.2014-0724","article-title":"Neonatal Encephalopathy and Neurologic Outcome, Second Edition","volume":"133","year":"2014","journal-title":"Pediatrics"},{"key":"ref21","article-title":"Magnetic resonance imaging obtained during versus after hypothermia in asphyxiated Newborns","author":"E Boudes","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref22","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"AJ Barkovich","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources","volume":"4","author":"DW Huang","year":"2009","journal-title":"Nature Protoc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"DW Huang","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/jnen\/61.4.339","article-title":"Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling","volume":"61","author":"H Beck","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00004647-200404000-00005","article-title":"Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat","volume":"24","author":"K Jin","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/01.STR.0000158905.22871.95","article-title":"Adenovirus-mediated gene transfer of heparin-binding epidermal growth factor-like growth factor enhances neurogenesis and angiogenesis after focal cerebral ischemia in rats","volume":"36","author":"S Sugiura","year":"2005","journal-title":"Stroke"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2011.04.034","article-title":"Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury","volume":"185","author":"A Oyagi","year":"2011","journal-title":"Neuroscience"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nbd.2009.12.024","article-title":"Galectin-3 contributes to neonatal hypoxic-ischemic brain injury","volume":"38","author":"C Doverhag","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12975-012-0216-3","article-title":"Microglia\/macrophage-derived inflammatory mediators galectin-3 and quinolinic acid are elevated in cerebrospinal fluid from newborn infants after birth asphyxia","volume":"4","author":"K Savman","year":"2013","journal-title":"Transl Stroke Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.ATV.0000105902.89459.09","article-title":"Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels","volume":"24","author":"P Delafontaine","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1074\/jbc.M111.267732","article-title":"Insulin-like growth factor binding protein-4 differentially inhibits growth factor-induced angiogenesis","volume":"287","author":"LW Contois","year":"2012","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/carcin\/bgn206","article-title":"Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis","volume":"29","author":"SB Rho","year":"2008","journal-title":"Carcinogenesis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000014599","article-title":"Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal rat brain","volume":"8","author":"TF Clawson","year":"1999","journal-title":"Biol Signals Recept"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00004647-199603000-00007","article-title":"Coordinate IGF-I and IGFBP5 gene expression in perinatal rat brain after hypoxia-ischemia","volume":"16","author":"WH Lee","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1203\/00006450-199903000-00005","article-title":"Possible protective role of growth hormone in hypoxia-ischemia in neonatal rats","volume":"45","author":"K Gustafson","year":"1999","journal-title":"Pediatr Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijdevneu.2009.09.002","article-title":"Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia","volume":"28","author":"M Beresewicz","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000074952","article-title":"Serum insulin-like growth factor 1 and growth hormone levels of hypoxic-ischemic newborns","volume":"85","author":"M Satar","year":"2004","journal-title":"Biol Neonate"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/glia.20169","article-title":"Multiple roles for MMPs and TIMPs in cerebral ischemia","volume":"50","author":"LA Cunningham","year":"2005","journal-title":"Glia"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1523\/JNEUROSCI.4391-06.2007","article-title":"Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia","volume":"27","author":"P Svedin","year":"2007","journal-title":"J Neurosci"},{"key":"ref41","first-page":"441","article-title":"Matrix metaloproteinases activity during the evolution of hypoxic-ischemic brain damage in the immature rat. The effect of 1-methylnicotinamide (MNA)","volume":"59","author":"P Dragun","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/pr.2011.3","article-title":"Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia: a potential marker of neonatal encephalopathy","volume":"71","author":"N Bednarek","year":"2012","journal-title":"Pediatr Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.braindev.2008.09.001","article-title":"Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in perinatal asphyxia","volume":"31","author":"S Sunagawa","year":"2009","journal-title":"Brain Dev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1055\/s-0037-1613388","article-title":"Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis","volume":"89","author":"RT Aimes","year":"2003","journal-title":"Thromb Haemost"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pathophys.2004.11.002","article-title":"Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke","volume":"12","author":"L Wei","year":"2005","journal-title":"Pathophysiology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain","volume":"106","author":"ZG Zhang","year":"2000","journal-title":"J Clin Invest"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2005.05.011","article-title":"Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats","volume":"1049","author":"T Abumiya","year":"2005","journal-title":"Brain Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.STR.0000165925.20413.14","article-title":"Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction","volume":"36","author":"R Kimura","year":"2005","journal-title":"Stroke"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00441-012-1401-0","article-title":"Transplantation of human umbilical cord blood cells mediated beneficial effects on apoptosis, angiogenesis and neuronal survival after hypoxic-ischemic brain injury in rats","volume":"348","author":"K Rosenkranz","year":"2012","journal-title":"Cell Tissue Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1203\/PDR.0b013e318180ebe6","article-title":"Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats","volume":"64","author":"Y Feng","year":"2008","journal-title":"Pediatr Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12975-012-0221-6","article-title":"Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke","volume":"4","author":"M Dzietko","year":"2013","journal-title":"Transl Stroke Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.braindev.2008.09.004","article-title":"Vascular endothelial growth factor in neonates with perinatal asphyxia","volume":"31","author":"H Aly","year":"2009","journal-title":"Brain Dev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1442-200X.2010.03290.x","article-title":"New insights into the pathogenesis of perinatal hypoxic-ischemic brain injury","volume":"53","author":"B Vasiljevic","year":"2011","journal-title":"Pediatr Int"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0387-7604(03)00166-9","article-title":"Cerebrospinal fluid and serum vascular endothelial growth factor and nitric oxide levels in newborns with hypoxic ischemic encephalopathy","volume":"26","author":"E Ergenekon","year":"2004","journal-title":"Brain Dev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cyto.2012.08.001","article-title":"Temporal alteration of serum G-CSF and VEGF levels in perinatal asphyxia treated with head cooling","volume":"60","author":"K Okazaki","year":"2012","journal-title":"Cytokine"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/ATVBAHA.109.184549","article-title":"Kallikrein\u2014Kinin System in Neovascularization","volume":"29","author":"M Bader","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3923\/pjbs.2009.1498.1504","article-title":"Cord blood brain derived neurotrophic factor: diagnostic and prognostic marker in fullterm newborns with perinatal asphyxia","volume":"12","author":"SS Imam","year":"2009","journal-title":"Pak J Biol Sci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12013-012-9478-3","article-title":"Dynamic changes of cerebral-specific proteins in full-term newborns with hypoxic-ischemic encephalopathy","volume":"66","author":"F Liu","year":"2013","journal-title":"Cell Biochem Biophys"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(97)00937-3","article-title":"Brain derived neurotrophic factor is increased in cerebrospinal fluid of children suffering from asphyxia","volume":"240","author":"L Korhonen","year":"1998","journal-title":"Neurosci Lett"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/00207454.2012.744755","article-title":"Changes of inflammatory cytokines and neurotrophins emphasized their roles in hypoxic-ischemic brain damage","volume":"123","author":"Y Wang","year":"2013","journal-title":"Int J Neurosci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nbd.2004.05.007","article-title":"Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury","volume":"17","author":"EM Graham","year":"2004","journal-title":"Neurobiol Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1161\/01.STR.28.11.2281","article-title":"Vulnerability to cerebral hypoxic-ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood-brain barrier","volume":"28","author":"K Muramatsu","year":"1997","journal-title":"Stroke"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T07:17:16Z","timestamp":1566717436000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128028"}},"subtitle":[],"editor":[{"given":"Masaki","family":"Mogi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,5,21]]},"references-count":62,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128028","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,21]]}}}