{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:57:14Z","timestamp":1791176234133,"version":"4.1.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128219","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T17:59:56Z","timestamp":1433440796000},"page":"e0128219","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Elevated Serum Level of IL-35 Associated with the Maintenance of Maternal-Fetal Immune Tolerance in Normal Pregnancy"],"prefix":"10.1371","volume":"10","author":[{"given":"Chao-yan","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-mei","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/aji.12067","article-title":"Regulatory T cells are baby&apos;s best friends","volume":"69","author":"A Teles","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nm.3160","article-title":"Fetomaternal immune cross-talk and its consequences for maternal and offspring&apos;s health","volume":"19","author":"PC Arck","year":"2013","journal-title":"Nat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-065X.2001.1820102.x","article-title":"Immunologic tolerance maintained by CD25+CD4+regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance","volume":"182","author":"S Sakaguchi","year":"2001","journal-title":"Immunol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e96723","DOI":"10.1371\/journal.pone.0096723","article-title":"Normal human pregnancy results in maternal immune activation in the periphery and at the uteroplacental interface","volume":"9","author":"AI Loewendorf","year":"2014","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus","volume":"5","author":"VR Aluvihare","year":"2004","journal-title":"Nat Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2249.2004.02441.x","article-title":"Phenotypic characterization of regulatory T cells in the human decidua","volume":"136","author":"J Heikkinen","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jri.2005.01.004","article-title":"CD4 (+) CD25 high regulatory T cells in human pregnancy","volume":"65","author":"S Saito","year":"2005","journal-title":"J Reprod Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4 + CD25 + T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"AC Zenclussen","year":"2005","journal-title":"Am J Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1095\/biolreprod.109.081208","article-title":"FOXP3<sup>+<\/sup> regulatory T cells and T helper1, T helper2, and T helper17 cells in human early pregnancy decidua","volume":"82","author":"J Mjosberg","year":"2010","journal-title":"Biol Reprod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2567.2004.01869.x","article-title":"Normal human pregnancy is associated with an elevation in the immune suppressive CD25 + CD4 + regulatory T-cell subset","volume":"112","author":"DA Somerset","year":"2004","journal-title":"Immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/molehr\/gah044","article-title":"Decidual and peripheral blood CD4 + CD25 + regulatory T cells in early pregnancy subjects and spontaneous abortion cases","volume":"10","author":"Y Sasaki","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.placenta.2005.11.008","article-title":"Differential distribution of CD4(+)CD25(bright) and CD8(+)CD28(-) T-cells in decidua and maternal blood during human pregnancy","volume":"27","author":"T Tilburgs","year":"2006","journal-title":"Placenta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jri.2007.06.052","article-title":"Fetal alloantigen is responsible for the expansion of the CD4 (+) CD25 (+) regulatory T cell pool during pregnancy","volume":"75","author":"JX Zhao","year":"2007","journal-title":"J Reprod Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1600-0897.2007.00538.x","article-title":"Kinetics of regulatory T cells during murine pregnancy","volume":"58","author":"C Thuere","year":"2007","journal-title":"Am J Reprod Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.clim.2009.08.009","article-title":"The CD4<sup>+<\/sup> CD25<sup>bright<\/sup> regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage","volume":"133","author":"LP Jin","year":"2009","journal-title":"Clin Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nature06306","article-title":"The inhibitory cytokine IL-35 contributes to regulatory T-cell function","volume":"450","author":"LW Collison","year":"2007","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.1952","article-title":"IL-35-mediated induction of a potent regulatory T cell population","volume":"11","author":"LW Collison","year":"2010","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/eji.200939527","article-title":"Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC","volume":"40","author":"M Seyerl","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref19","article-title":"Eur J Immunol","author":"KO Dixon","year":"2015"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nrrheum.2014.95","article-title":"Autoimmunity: regulatory B cells\u2014IL-35 and IL-21 regulate the regulators","volume":"10","author":"TF Tedder","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature12979","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"P Shen","year":"2014","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ni.2406","article-title":"From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines","volume":"13","author":"J Banchereau","year":"2013","journal-title":"Nat Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e96120","DOI":"10.1371\/journal.pone.0096120","article-title":"Contribution of IL-12\/IL-35 common subunit p35 to maintaining the testicular immune privilege","volume":"9","author":"H Terayama","year":"2014","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"DA Vignali","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00018-009-0026-2","article-title":"The development and function of regulatory T cells","volume":"66","author":"CJ Workman","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref26","first-page":"258391","article-title":"Immunologic regulation in pregnancy: from mechanism to therapeutic strategy for immunomodulation","volume":"2012","author":"SJ Chen","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/10408360601003143","article-title":"Tumor markers in biological fluids associated with pregnancy","volume":"44","author":"A Sarandakou","year":"2007","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.mayocp.2014.01.006","article-title":"Immunomodulatory Effects of Sex Hormones: Requirements for Pregnancy and Relevance in Melanoma","volume":"89","author":"EA Enninga","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.4049\/jimmunol.0803177","article-title":"Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy","volume":"182","author":"A Schumacher","year":"2009","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.fertnstert.2009.11.020","article-title":"Changes of CD4 + CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients","volume":"94","author":"S Mei","year":"2010","journal-title":"Fertil Steril"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/humrep\/der301","article-title":"An imbalance in interleukin-17-producing T and Foxp3 regulatory T cells in women with idiopathic recurrent pregnancy loss","volume":"26","author":"SK Lee","year":"2011","journal-title":"Hum Reprod"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejogrb.2010.11.007","article-title":"Decidual CD4<sup>+<\/sup> CD25<sup>+<\/sup> CD127<sup>dim\/-<\/sup> regulatory T cells in patients with unexplained recurrent spontaneous miscarriage","volume":"155","author":"SH Bao","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.humimm.2013.04.010","article-title":"Human placental trophoblasts express the immunosuppressive cytokine IL-35","volume":"74","author":"H Mao","year":"2013","journal-title":"Hum Immunol"},{"key":"ref34","first-page":"1353","article-title":"The regular distribution and expression pattern of immunosuppressive cytokine IL-35 in mouse uterus during early pregnancy","volume":"55","author":"E Jin","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"ref35","first-page":"1","article-title":"What is the impact of SOCS3, IL-35 and IL17 in immune pathogenesis of recurrent pregnancy loss?","volume":"22","author":"ZS Ozkan","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3109\/14767058.2013.861415","article-title":"Plasma IL-17, IL-35, interferon-\u03b3, SOCS3 and TGF-\u03b2 levels in pregnant women with preeclampsia, and their relation with severity of disease","volume":"27","author":"ZS Ozkan","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1600-0897.2010.00852.x","article-title":"Th1\/Th2\/Th17 and regulatory T-cell paradigm in pregnancy","volume":"63","author":"S Saito","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1600-0897.2008.00582.x","article-title":"Prevention of spontaneous abortion in the CBA x DBA\/2 mouse model by intravaginal TGF-beta and local recruitment of CD4 + 8 + FOXP3+cells","volume":"59","author":"DA Clark","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jri.2010.02.006","article-title":"Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice","volume":"85","author":"T Shima","year":"2010","journal-title":"J Reprod Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0165-0378(01)00065-1","article-title":"The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice","volume":"51","author":"L Svensson","year":"2001","journal-title":"J Reprod Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.4049\/jimmunol.1100315","article-title":"Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance","volume":"186","author":"V Chaturvedi","year":"2001","journal-title":"J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.4049\/jimmunol.180.7.5109","article-title":"Human CD4+ T cells recognize an epitope within a-fetoprotein sequence and develop into TGF-b-producing CD4+ T cell","volume":"180","author":"A Alisa","year":"2008","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1134\/S0012496611050024","article-title":"Influence of reproductive hormones on the induction of CD4(+)CD25 (bright)Foxp (3+) regulatory T cells","volume":"440","author":"SV Shirshev","year":"2011","journal-title":"Dokl Biol Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2567.2006.02339.x","article-title":"Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation","volume":"118","author":"GA Prieto","year":"2006","journal-title":"Immunology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jcp.21221","article-title":"Induction of regulatory T cells by physiological level estrogen","volume":"214","author":"P Tai","year":"2008","journal-title":"J Cell Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1210\/en.2010-0426","article-title":"Progesterone increases systemic and local uterine proportions of CD4+CD25+Treg cells during midterm pregnancy in mice","volume":"151","author":"G Mao","year":"2010","journal-title":"Endocrinology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2362.2010.02414.x","article-title":"Estradiol-dependent perforin expression by human regulatory T cells","volume":"41","author":"L Valor","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jneuroim.2005.08.023","article-title":"Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice","volume":"170","author":"MJ Polanczyk","year":"2005","journal-title":"J Neuroimmunol"},{"key":"ref49","first-page":"2593","article-title":"Pregnancy estrogen drives the changes of T-lymphocyte subsets and cytokines and prolongs the survival of H-Y skin graft in murine model","volume":"123","author":"X Lin","year":"2010","journal-title":"Chin Med J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/eji.200737810","article-title":"IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells","volume":"37","author":"W Niedbala","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref51","article-title":"Clin Rev Allergy Immunol","author":"J Choi","year":"2015"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.3554","article-title":"Interleukin-35 Induces Regulatory B Cells that Suppress CNS Autoimmune Disease","volume":"20","author":"RX Wang","year":"2014","journal-title":"Nat Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T02:44:47Z","timestamp":1540349087000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128219"}},"subtitle":[],"editor":[{"given":"Sing Sing","family":"Way","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,4]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128219","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,4]]}}}