{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:21:40Z","timestamp":1765887700020},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128373","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T18:28:26Z","timestamp":1435170506000},"page":"e0128373","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide"],"prefix":"10.1371","volume":"10","author":[{"given":"Martijn J. C.","family":"van Herwijnen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruurd","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"van Eden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Broere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"S Sakaguchi","year":"1995","journal-title":"J Immunol"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.immuni.2009.05.002","article-title":"Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?","volume":"30","author":"MA Curotto de Lafaille","year":"2009","journal-title":"Immunity"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.autrev.2011.05.004","article-title":"Human FoxP3+ regulatory T cells in systemic autoimmune diseases","volume":"10","author":"M Miyara","year":"2011","journal-title":"Autoimmun Rev"},{"key":"ref4","first-page":"733","article-title":"Induced CD4+Foxp3+ regulatory T cells in immune tolerance","author":"AM Bilate","year":"2011","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1517\/14728222.2012.706605","article-title":"Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions","volume":"16","author":"C Keijzer","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.semarthrit.2007.10.002","article-title":"Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis","volume":"38","author":"SR Satpute","year":"2008","journal-title":"Semin Arthritis Rheum"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri2153","article-title":"Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease","volume":"7","author":"SD Miller","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/eji.200838819","article-title":"Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects","volume":"39","author":"SA Long","year":"2009","journal-title":"Eur J Immunol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1172\/JCI2465","article-title":"Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs","volume":"102","author":"G Schett","year":"1998","journal-title":"J Clin Invest"},{"issue":"35","key":"ref10","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.1206803109","article-title":"Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis","volume":"109","author":"MJ Van Herwijnen","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"e4186","DOI":"10.1371\/journal.pone.0004186","article-title":"IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis","volume":"4","author":"L Wieten","year":"2009","journal-title":"PLoS One"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/art.20180","article-title":"Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype","volume":"50","author":"A Hanyecz","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.4049\/jimmunol.163.10.5560","article-title":"Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis","volume":"163","author":"S Tanaka","year":"1999","journal-title":"J Immunol"},{"issue":"9295","key":"ref14","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(01)06801-5","article-title":"Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial","volume":"358","author":"I Raz","year":"2001","journal-title":"Lancet"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1073\/pnas.0400061101","article-title":"Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis","volume":"101","author":"BJ Prakken","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6152","key":"ref16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/331171a0","article-title":"Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis","volume":"331","author":"W1 Van Eden","year":"1988","journal-title":"Nature"},{"key":"ref17","first-page":"145","article-title":"Heat shock proteins as antigens of bacterial and parasitic pathogens","author":"TM Shinnick","year":"1991","journal-title":"Curr Top Microbiol Immunol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1084\/jem.175.6.1805","article-title":"Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis","volume":"175","author":"CJ Boog","year":"1992","journal-title":"J Exp Med"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/ar144","article-title":"The stressed synovium","volume":"3","author":"G Schett","year":"2001","journal-title":"Arthritis Res"},{"issue":"Suppl 2","key":"ref20","doi-asserted-by":"crossref","first-page":"14622","DOI":"10.1073\/pnas.0405234101","article-title":"Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells","volume":"101","author":"JA Bluestone","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"45","key":"ref21","doi-asserted-by":"crossref","first-page":"19078","DOI":"10.1073\/pnas.0907396106","article-title":"Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis","volume":"106","author":"GP Wright","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ni1318","article-title":"An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires","volume":"7","author":"CS Hsieh","year":"2006","journal-title":"Nat Immunol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1084\/jem.20011288","article-title":"Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis","volume":"195","author":"P McGuirk","year":"2002","journal-title":"J Exp Med"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.immuni.2011.03.029","article-title":"A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity","volume":"35","author":"D Haribhai","year":"2011","journal-title":"Immunity"},{"issue":"22","key":"ref25","doi-asserted-by":"crossref","first-page":"7922","DOI":"10.1073\/pnas.0501190102","article-title":"Autophagy promotes MHC class II presentation of peptides from intracellular source proteins","volume":"102","author":"J Dengjel","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.4049\/jimmunol.173.2.1085","article-title":"Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: strong influence of invariant chain and HLA-DM expression on the nature of ligands","volume":"173","author":"A1 Muntasell","year":"2004","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1749-6632.2002.tb02995.x","article-title":"Molecular modeling of eluted peptides from DQ6 molecules (DQB1*0602 and DQB1*0604) negatively and positively associated with type 1 diabetes","volume":"958","author":"CB Sanjeevi","year":"2002","journal-title":"Ann N Y Acad Sci"},{"issue":"15","key":"ref28","first-page":"3238","article-title":"Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3","volume":"57","author":"T Halder","year":"1997","journal-title":"Cancer Res"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"S Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"C1018","DOI":"10.1152\/ajpcell.00131.2005","article-title":"Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells","volume":"290","author":"Y Tao","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1593","article-title":"Heat-shock proteins induce T-cell regulation of chronic inflammation","volume":"5","author":"W van Eden","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/eji.200939613","article-title":"In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes","volume":"40","author":"YY Setiady","year":"2010","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1574-695X.2011.00805.x","article-title":"Depletion with PC61 mAb before Toxoplasma gondii infection eliminates mainly Tregs in BALB\/c mice, but activated cells in C57BL\/6J mice","volume":"62","author":"EP Tenorio","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1002\/art.34513","article-title":"Antigen-specific transforming growth factor beta-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17\/Treg cell balance from Th17 predominance to Treg cell predominance","volume":"64","author":"N Kong","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.4049\/jimmunol.177.12.8338","article-title":"Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients","volume":"177","author":"M Battaglia","year":"2006","journal-title":"J Immunol"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"e5994","DOI":"10.1371\/journal.pone.0005994","article-title":"Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin","volume":"4","author":"L Strauss","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.4049\/jimmunol.178.7.4022","article-title":"Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells","volume":"178","author":"TS Davidson","year":"2007","journal-title":"J Immunol"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1182\/blood-2010-10-313684","article-title":"Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells","volume":"118","author":"HJ Shin","year":"2011","journal-title":"Blood"},{"issue":"22","key":"ref39","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1056\/NEJMoa012864","article-title":"Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus","volume":"346","author":"KC Herold","year":"2002","journal-title":"N Engl J Med"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"e24226","DOI":"10.1371\/journal.pone.0024226","article-title":"Helios expression is a marker of T cell activation and proliferation","volume":"6","author":"T Akimova","year":"2011","journal-title":"PLoS One"},{"issue":"18","key":"ref41","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1182\/blood-2009-05-219584","article-title":"Epigenetic mechanisms of regulation of Foxp3 expression","volume":"114","author":"G Lal","year":"2009","journal-title":"Blood"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.1203473","article-title":"Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus","volume":"190","author":"A Toker","year":"2013","journal-title":"J Immunol"},{"issue":"158","key":"ref43","doi-asserted-by":"crossref","first-page":"pe4","DOI":"10.1126\/scisignal.2001783","article-title":"To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms","volume":"4","author":"A Toker","year":"2011","journal-title":"Sci Signal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T19:28:10Z","timestamp":1691782090000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128373"}},"subtitle":[],"editor":[{"given":"Lucienne","family":"Chatenoud","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128373","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,24]]}}}