{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:12:37Z","timestamp":1773976357258,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128410","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T18:00:17Z","timestamp":1433959217000},"page":"e0128410","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["High Incidences of Invasive Fungal Infections in Acute Myeloid Leukemia Patients Receiving Induction Chemotherapy without Systemic Antifungal Prophylaxis: A Prospective Observational Study in Taiwan"],"prefix":"10.1371","volume":"10","author":[{"given":"Jih-Luh","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Chi","family":"Kung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weng-Chi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Un-In","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Chun","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Ju","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-An","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chien","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woei","family":"Tsay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Chwen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor-Sheng","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwei-Fang","family":"Tien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1086\/513943","article-title":"Invasive aspergillosis","volume":"26","author":"DW Denning","year":"1998","journal-title":"Clin Infect Dis"},{"key":"ref2","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study","volume":"91","author":"L Pagano","year":"2006","journal-title":"Haematologica"},{"key":"ref3","first-page":"862","article-title":"Infections caused by filamentous fungi in patients with hematologic malignancies. A report of 391 cases by GIMEMA Infection Program","volume":"86","author":"L Pagano","year":"2001","journal-title":"Haematologica"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3324\/haematol.2011.051995","article-title":"Comparative clinical effectiveness of prophylactic voriconazole\/posaconazole to fluconazole\/itraconazole in patients with acute myeloid leukemia\/myelodysplastic syndrome undergoing cytotoxic chemotherapy over a 12-year period","volume":"97","author":"MR Ananda-Rajah","year":"2012","journal-title":"Haematologica"},{"key":"ref5","first-page":"986","article-title":"Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989\u20132003)","volume":"91","author":"G Chamilos","year":"2006","journal-title":"Haematologica"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/AAC.01525-13","article-title":"Incidence density of invasive fungal infections during primary antifungal prophylaxis in newly diagnosed acute myeloid leukemia patients in a tertiary cancer center, 2009 to 2011","volume":"58","author":"MZ Gomes","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/jac\/dkp507","article-title":"Overall survival and fungal infection-related mortality in patients with invasive fungal infection and neutropenia after myelosuppressive chemotherapy in a tertiary care centre from 1995 to 2006","volume":"65","author":"C Hahn-Ast","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ajh.21776","article-title":"Invasive fungal disease in patients treated for newly diagnosed acute leukemia","volume":"85","author":"SP Hammond","year":"2010","journal-title":"Am J Hematol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s12185-012-1210-y","article-title":"Epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies","volume":"96","author":"M Kurosawa","year":"2012","journal-title":"Int J Hematol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1600-0609.2008.01122.x","article-title":"Incidence of bacterial and fungal infections in newly diagnosed acute myeloid leukaemia patients younger than 65 yr treated with induction regimens including fludarabine: retrospective analysis of 224 cases","volume":"81","author":"M Malagola","year":"2008","journal-title":"Eur J Haematol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.diagmicrobio.2012.10.001","article-title":"Epidemiology, outcomes, and risk factors of invasive fungal infections in adult patients with acute myelogenous leukemia after induction chemotherapy","volume":"75","author":"D Neofytos","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3324\/haematol.2014.113399","article-title":"Pre-chemotherapy risk factors for invasive fungal diseases: prospective analysis of 1,192 patients with newly diagnosed acute myeloid leukemia (SEIFEM 2010-a multicenter study)","volume":"100","author":"M Caira","year":"2015","journal-title":"Haematologica"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1365-2141.2000.02014.x","article-title":"Towards a targeted, risk-based, antifungal strategy in neutropenic patients","volume":"110","author":"HG Prentice","year":"2000","journal-title":"Br J Haematol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e27163","DOI":"10.1371\/journal.pone.0027163","article-title":"Effectiveness and limitations of hand hygiene promotion on decreasing healthcare-associated infections","volume":"6","author":"YC Chen","year":"2011","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2009-07-235358","article-title":"Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet","volume":"115","author":"H Dohner","year":"2010","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"46","author":"B De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3324\/haematol.2012.061952","article-title":"The role of antifungal treatment in hematology","volume":"97","author":"JA Maertens","year":"2012","journal-title":"Haematologica"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/323335","article-title":"Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus","volume":"34","author":"S Ascioglu","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/1469-0691.12002","article-title":"Invasive fungal diseases in haematopoietic cell transplant recipients and in patients with acute myeloid leukaemia or myelodysplasia in Brazil","volume":"19","author":"M Nucci","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00001432-200012000-00006","article-title":"The changing spectrum of candidemia in oncology patients: therapeutic implications","volume":"13","author":"KA Marr","year":"2000","journal-title":"Curr Opin Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1086\/649879","article-title":"Fungal infections in leukemia patients: how do we prevent and treat them","volume":"50","author":"K Leventakos","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1086\/323895","article-title":"Trends in the epidemiology of opportunistic fungal infections: predisposing factors and the impact of antimicrobial use practices","volume":"33","author":"N Singh","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1002\/cncr.24507","article-title":"Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001\u20132007): stable incidence but changing epidemiology of a still frequently lethal infection","volume":"115","author":"NV Sipsas","year":"2009","journal-title":"Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0929-6646(09)60091-7","article-title":"Invasive candidiasis: an overview from Taiwan","volume":"108","author":"SY Ruan","year":"2009","journal-title":"J Formos Med Assoc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3109\/13693780903154070","article-title":"The distribution of species and susceptibility of amphotericin B and fluconazole of yeast pathogens isolated from sterile sites in Taiwan","volume":"48","author":"YL Yang","year":"2010","journal-title":"Med Mycol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jmii.2010.08.010","article-title":"Candida albicans versus non-albicans bloodstream infections: the comparison of risk factors and outcome","volume":"44","author":"HW Chi","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00277-002-0588-7","article-title":"Hepatosplenic fungal infection in patients with acute leukemia in Taiwan: incidence, treatment, and prognosis","volume":"82","author":"CY Chen","year":"2003","journal-title":"Ann Hematol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.leukres.2014.01.007","article-title":"Invasive fungal diseases during first induction chemotherapy affect complete remission achievement and long-term survival of patients with acute myeloid leukemia","volume":"38","author":"C Girmenia","year":"2014","journal-title":"Leuk Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s10096-011-1397-5","article-title":"Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients","volume":"31","author":"M Michallet","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3324\/haematol.2010.030825","article-title":"Impact of invasive fungal disease on the chemotherapy schedule and event-free survival in acute leukemia patients who survived fungal disease: a case-control study","volume":"96","author":"C Even","year":"2011","journal-title":"Haematologica"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1002\/cncr.10610","article-title":"Antifungal prophylaxis for severely neutropenic chemotherapy recipients: a meta analysis of randomized-controlled clinical trials","volume":"94","author":"EJ Bow","year":"2002","journal-title":"Cancer"},{"issue":"Suppl 2","key":"ref32","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1007\/s00277-003-0773-3","article-title":"Prophylaxis of invasive fungal infections in patients with hematological malignancies and solid tumors\u2014guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)","volume":"82","author":"OA Cornely","year":"2003","journal-title":"Ann Hematol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJMoa061094","article-title":"Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia","volume":"356","author":"OA Cornely","year":"2007","journal-title":"N Engl J Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T12:08:02Z","timestamp":1717934882000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128410"}},"subtitle":[],"editor":[{"given":"Patrick CY","family":"Woo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128410","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}