{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:50:29Z","timestamp":1790092229783,"version":"4.0.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128423","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T18:01:34Z","timestamp":1433786494000},"page":"e0128423","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Role of Staphylococcus aureus Virulence Factors in Inducing Inflammation and Vascular Permeability in a Mouse Model of Bacterial Endophthalmitis"],"prefix":"10.1371","volume":"10","author":[{"given":"Ajay","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1469-0691.12118","article-title":"Endophthalmitis","volume":"19","author":"ML Durand","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.preteyeres.2006.12.001","article-title":"Bacterial endophthalmitis: therapeutic challenges and host-pathogen interactions","volume":"26","author":"MC Callegan","year":"2007","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1097\/IAE.0b013e318206d176","article-title":"Efficacy of vitrectomy in improving the outcome of Bacillus cereus endophthalmitis","volume":"31","author":"MC Callegan","year":"2011","journal-title":"Retina"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/02713680600976925","article-title":"Acute inflammation and loss of retinal architecture and function during experimental Bacillus endophthalmitis","volume":"31","author":"RT Ramadan","year":"2006","journal-title":"Curr Eye Res"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1086\/649589","article-title":"Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis","volume":"201","author":"A Kumar","year":"2010","journal-title":"J Infect Dis"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1128\/IAI.65.4.1550-1556.1997","article-title":"Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis","volume":"65","author":"MC Booth","year":"1997","journal-title":"Infect Immun"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1128\/IAI.00405-12","article-title":"Increased resistance to Staphylococcus aureus endophthalmitis in BALB\/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance","volume":"81","author":"N Sugi","year":"2013","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.preteyeres.2006.12.001","article-title":"Bacterial endophthalmitis: therapeutic challenges and host-pathogen interactions","volume":"26","author":"M Callegan","year":"2007","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajo.2009.08.023","article-title":"Staphylococcus aureus endophthalmitis: antibiotic susceptibilities, methicillin resistance, and clinical outcomes","volume":"149","author":"JC Major Jr","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000099277","article-title":"Role of bacterial and host factors in infectious endophthalmitis","volume":"92","author":"M Gregory","year":"2007","journal-title":"Chem Immunol Allergy"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02849853","article-title":"Antibacterial activity of the fourth-generation fluoroquinolones gatifloxacin and moxifloxacin against ocular pathogens","volume":"20","author":"MC Callegan","year":"2003","journal-title":"Adv Ther"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/infdis\/165.6.1033","article-title":"beta-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime","volume":"165","author":"JJ Jackson","year":"1992","journal-title":"J Infect Dis"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/AAC.42.4.739","article-title":"Antibiotic-induced lipopolysaccharide (LPS) release from Salmonella typhi: delay between killing by ceftazidime and imipenem and release of LPS","volume":"42","author":"P van Langevelde","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1128\/IAI.67.7.3348-3356.1999","article-title":"Pathogenesis of gram-positive bacterial endophthalmitis","volume":"67","author":"MC Callegan","year":"1999","journal-title":"Infect Immun"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1001\/archopht.1984.01040030857033","article-title":"Experimental uveitis. Elicited by peptidoglycan-polysaccharide complexes, lipopolysaccharide, and muramyl dipeptide","volume":"102","author":"A Fox","year":"1984","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"ref16","first-page":"609","article-title":"Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases","volume":"138","author":"RK Pandey","year":"2013","journal-title":"Indian J Med Res"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1615\/CritRevImmunol.2013006618","article-title":"Muller glia in retinal innate immunity: a perspective on their roles in endophthalmitis","volume":"33","author":"A Kumar","year":"2013","journal-title":"Crit Rev Immunol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1128\/IAI.00149-12","article-title":"Toll-Like Receptor 2 Ligand Pretreatment Attenuates Retinal Microglial Inflammatory Response but Enhances Phagocytic Activity toward Staphylococcus aureus","volume":"80","author":"T Kochan","year":"2012","journal-title":"Infect Immun"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/IAI.66.1.356-360.1998","article-title":"Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis","volume":"66","author":"MC Booth","year":"1998","journal-title":"Infect Immun"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/jb.170.9.4365-4372.1988","article-title":"Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus","volume":"170","author":"HL Peng","year":"1988","journal-title":"J Bacteriol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"e29830","DOI":"10.1371\/journal.pone.0029830","article-title":"Retinal Muller glia initiate innate response to infectious stimuli via toll-like receptor signaling","volume":"7","author":"A Kumar","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1167\/iovs.10-5431","article-title":"In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death","volume":"51","author":"Y Bai","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1167\/iovs.13-13401","article-title":"Pathogenicity of ocular isolates of Acinetobacter baumannii in a mouse model of bacterial endophthalmitis","volume":"55","author":"D Talreja","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1167\/iovs.04-1139","article-title":"Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis","volume":"46","author":"M Engelbert","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1167\/iovs.02-1250","article-title":"Mitigation of neutrophil infiltration in a rat model of early Staphylococcus aureus endophthalmitis","volume":"44","author":"MJ Giese","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1167\/iovs.08-3051","article-title":"Bacillus cereus-induced permeability of the blood-ocular barrier during experimental endophthalmitis","volume":"50","author":"AL Moyer","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0002-9440(10)64982-6","article-title":"Breakdown of the blood-retinal barrier induced by activated T cells of nonneural specificity","volume":"156","author":"P Hu","year":"2000","journal-title":"Am J Pathol"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1128\/AAC.00126-14","article-title":"Intravitreal Injection of the Chimeric Phage Endolysin Ply187 Protects Mice from Staphylococcus aureus Endophthalmitis","volume":"58","author":"PK Singh","year":"2014","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.preteyeres.2012.03.004","article-title":"Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host\u2013microbe interactions in intraocular infection","volume":"31","author":"A Sadaka","year":"2012","journal-title":"Progress in Retinal and Eye Research"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1089\/jop.2011.0107","article-title":"Staphylococcus aureus isolated from endophthalmitis are hospital-acquired based on Panton-Valentine leukocidin and antibiotic susceptibility testing","volume":"28","author":"KA Rarey","year":"2012","journal-title":"J Ocul Pharmacol Ther"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1128\/IAI.01285-07","article-title":"alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis","volume":"76","author":"EA Whiston","year":"2008","journal-title":"Infect Immun"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"799","DOI":"10.5301\/ijao.5000030","article-title":"Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus","volume":"34","author":"G Pietrocola","year":"2011","journal-title":"Int J Artif Organs"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1128\/jb.169.6.2482-2487.1987","article-title":"Structure of the Staphylococcus aureus cell wall determined by the freeze-substitution method","volume":"169","author":"A Umeda","year":"1987","journal-title":"J Bacteriol"},{"key":"ref34","article-title":"In vivo role of TLR2 and MyD88 signaling in eliciting innate immune responses in Staphylococcal endophthalmitis","author":"D Talreja","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.4049\/jimmunol.1100565","article-title":"TLR2 mediates the innate response of retinal Muller glia to Staphylococcus aureus","volume":"186","author":"N Shamsuddin","year":"2011","journal-title":"J Immunol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1742-2094-11-33","article-title":"Antibacterial responses of retinal Muller glia: production of antimicrobial peptides, oxidative burst and phagocytosis","volume":"11","author":"P Singh","year":"2014","journal-title":"Journal of Neuroinflammation"},{"issue":"0","key":"ref37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mib.2013.11.004","article-title":"Staphylococcus aureus toxins","volume":"17","author":"M Otto","year":"2014","journal-title":"Current Opinion in Microbiology"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"e00764","DOI":"10.1128\/mBio.00764-13","article-title":"Staphylococcus aureus protein A promotes immune suppression","volume":"4","author":"SD Kobayashi","year":"2013","journal-title":"MBio"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2180-14-63","article-title":"Prevalence of Staphylococcus aureus protein A (spa) mutants in the community and hospitals in Oxfordshire","volume":"14","author":"AA Votintseva","year":"2014","journal-title":"BMC Microbiol"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.bbrc.2007.01.072","article-title":"Staphylococcus aureus protein A induced inflammatory response in human corneal epithelial cells","volume":"354","author":"A Kumar","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0625.2010.01174.x","article-title":"TNF receptor I on human keratinocytes is a binding partner for staphylococcal protein A resulting in the activation of NF kappa B, AP-1, and downstream gene transcription","volume":"20","author":"A Classen","year":"2011","journal-title":"Exp Dermatol"},{"issue":"8","key":"ref42","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nm1079","article-title":"Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1","volume":"10","author":"MI Gomez","year":"2004","journal-title":"Nat Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens: an update","volume":"55","author":"JK McCormick","year":"2001","journal-title":"Annu Rev Microbiol"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/IAI.73.4.2164-2174.2005","article-title":"The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1","volume":"73","author":"ML Peterson","year":"2005","journal-title":"Infect Immun"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"e32813","DOI":"10.1371\/journal.pone.0032813","article-title":"Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1","volume":"7","author":"MM Schaefers","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1128\/MMBR.55.4.733-751.1991","article-title":"Alpha-toxin of Staphylococcus aureus","volume":"55","author":"S Bhakdi","year":"1991","journal-title":"Microbiol Rev"},{"issue":"8718","key":"ref47","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0140-6736(90)93237-J","article-title":"Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin","volume":"336","author":"M Steinbakk","year":"1990","journal-title":"Lancet"},{"issue":"9","key":"ref48","first-page":"1828","article-title":"Accessory gene regulator controls Staphylococcus aureus virulence in endophthalmitis","volume":"36","author":"MC Booth","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/infdis\/jir846","article-title":"Staphylococcus aureus alpha-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome","volume":"205","author":"C Kebaier","year":"2012","journal-title":"J Infect Dis"},{"issue":"9","key":"ref50","doi-asserted-by":"crossref","first-page":"e74010","DOI":"10.1371\/journal.pone.0074010","article-title":"Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells","volume":"8","author":"VE McGilligan","year":"2013","journal-title":"PLoS One"},{"key":"ref51","article-title":"MMP13 as a target for suppressing corneal ulceration caused by Pseudomonas aeruginosa infection","author":"N Gao","year":"2015","journal-title":"J Infect Dis"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/labinvest.3700251","article-title":"Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier","volume":"85","author":"SJ Giebel","year":"2005","journal-title":"Lab Invest"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1086\/315810","article-title":"Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14)","volume":"182","author":"PG Sohnle","year":"2000","journal-title":"J Infect Dis"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"e2296","DOI":"10.1371\/journal.pone.0002296","article-title":"Early neurodegeneration progresses independently of microglial activation by heparan sulfate in the brain of mucopolysaccharidosis IIIB mice","volume":"3","author":"J Ausseil","year":"2008","journal-title":"PLoS One"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","article-title":"S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules","volume":"81","author":"D Foell","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"14","key":"ref56","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1074\/jbc.272.14.9496","article-title":"Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway","volume":"272","author":"A Rammes","year":"1997","journal-title":"J Biol Chem"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.1104648","article-title":"The cytokine activity of HMGB1","volume":"78","author":"H Yang","year":"2005","journal-title":"J Leukoc Biol"},{"issue":"6","key":"ref58","first-page":"850","article-title":"Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha","volume":"70","author":"L Claudio","year":"1994","journal-title":"Lab Invest"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1167\/iovs.07-1303","article-title":"Toward improving therapeutic regimens for Bacillus endophthalmitis","volume":"49","author":"BJ Wiskur","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T04:47:08Z","timestamp":1599108428000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128423"}},"subtitle":[],"editor":[{"given":"Lbachir","family":"BenMohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128423","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]}}}