{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:50:20Z","timestamp":1791647420442,"version":"4.3.4"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128822","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T14:16:56Z","timestamp":1433945816000},"page":"e0128822","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Impaired Cellular Immunity in the Murine Neural Crest Conditional Deletion of Endothelin Receptor-B Model of Hirschsprung\u2019s Disease"],"prefix":"10.1371","volume":"10","author":[{"given":"Ankush","family":"Gosain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Barlow-Anacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris S.","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron F.","family":"Heneghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles L.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Kudsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"J Amiel","year":"2008","journal-title":"J Med Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jpedsurg.2014.01.060","article-title":"Intestinal dysbiosis and bacterial enteroinvasion in a murine model of Hirschsprung's disease","volume":"49","author":"JF Pierre","year":"2014","journal-title":"J Pediatr Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ydbio.2012.01.012","article-title":"The enteric nervous system","volume":"366","author":"V Sasselli","year":"2012","journal-title":"Dev Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1365-2982.2012.01937.x","article-title":"Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome","volume":"24","author":"NL Ward","year":"2012","journal-title":"Neurogastroenterology & Motility"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.sempedsurg.2012.07.006","article-title":"The pathogenesis of Hirschsprung\u2019s disease-associated enterocolitis","volume":"21","author":"KM Austin","year":"2012","journal-title":"Semin Pediatr Surg. Elsevier Inc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1053\/j.sempedsurg.2012.07.007","article-title":"Hirschsprung-associated enterocolitis: prevention and therapy","volume":"21","author":"PK Frykman","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/j.sempedsurg.2009.11.015","article-title":"Genetics of Hirschsprung disease and anorectal malformations","volume":"19","author":"E Mundt","year":"2010","journal-title":"Semin Pediatr Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ng868","article-title":"Segregation at three loci explains familial and population risk in Hirschsprung disease","volume":"31","author":"SB Gabriel","year":"2002","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/GIM.0b013e3181c371b0","article-title":"New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease","volume":"12","author":"A S\u00e1nchez-Mej\u00edas","year":"2010","journal-title":"Genet Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0022-3468(97)90616-3","article-title":"Mutation analysis of the RET, the endothelin-B receptor, and the endothelin-3 genes in sporadic cases of Hirschsprung's disease","volume":"32","author":"T Kusafuka","year":"1997","journal-title":"J Pediatr Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/hmg\/5.3.347","article-title":"Novel mutations of the endothelin-B receptor gene in isolated patients with Hirschsprung's disease","volume":"5","author":"T Kusafuka","year":"1996","journal-title":"Human Molecular Genetics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/hmg\/5.3.351","article-title":"Endothelin-B receptor mutations in patients with isolated Hirschsprung disease from a non-inbred population","volume":"5","author":"A Auricchio","year":"1996","journal-title":"Human Molecular Genetics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0092-8674(94)90016-7","article-title":"A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease","volume":"79","author":"EG Puffenberger","year":"1994","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00383-010-2848-2","article-title":"Hirschsprung's disease: what about mortality?","volume":"27","author":"A Pini-Prato","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tins.2010.06.002","article-title":"Developmental determinants of the independence and complexity of the enteric nervous system","volume":"33","author":"MD Gershon","year":"2010","journal-title":"Trends Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/bdra.23016","article-title":"Hirschsprung's disease in the North of England: prevalence, associated anomalies, and survival","volume":"94","author":"KE Best","year":"2012","journal-title":"Birth Defects Res Part A Clin Mol Teratol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0022-3468(95)90682-7","article-title":"Gastrointestinal function after surgical correction of Hirschsprung's disease: long-term follow-up in 135 patients","volume":"30","author":"TL Marty","year":"1995","journal-title":"J Pediatr Surg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature05597","article-title":"Tyrosine kinase receptor RET is a key regulator of Peyer\u2019s Patch organogenesis","volume":"446","author":"H Veiga-Fernandes","year":"2007","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00000658-198509000-00012","article-title":"A ten-year experience with ninety-two cases of Hirschsprung's disease. Including sixty-seven consecutive endorectal pull-through procedures","volume":"202","author":"TZ Polley","year":"1985","journal-title":"Ann Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jpedsurg.2009.10.035","article-title":"Murine model of Hirschsprung-associated enterocolitis II: Surgical correction of aganglionosis does not eliminate enterocolitis","volume":"45","author":"L Zhao","year":"2010","journal-title":"J Pediatr Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pedneo.2012.01.011","article-title":"Clinical Impacts of Delayed Diagnosis of Hirschsprung\u2019s Disease in Newborn Infants","volume":"53","author":"C-C Lee","year":"2012","journal-title":"Pediatrics and Neonatology. Elsevier Taiwan LLC"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-3083.2009.02319.x","article-title":"Mucosal immunity: induction, dissemination, and effector functions","volume":"70","author":"P Brandtzaeg","year":"2009","journal-title":"Scand J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00383-005-1551-1","article-title":"New insights into the pathogenesis of Hirschsprung's associated enterocolitis","volume":"21","author":"F Murphy","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/eji.201444737","article-title":"Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis","volume":"45","author":"PK Frykman","year":"2015","journal-title":"Eur J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret","volume":"367","author":"A Schuchardt","year":"1994","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e99944","DOI":"10.1371\/journal.pone.0099944","article-title":"Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease","volume":"9","author":"JR Thiagarajah","year":"2014","journal-title":"PLoS ONE"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0002-9610(62)90016-8","article-title":"The enterocolitis of Hirschsprung's disease: its natural history and treatment","volume":"43","author":"AH Bill","year":"1962","journal-title":"Am J Surg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0022-3468(89)80566-4","article-title":"The pathophysiology of Hirschsprung's-associated enterocolitis: importance of histologic correlates","volume":"24","author":"DH Teitelbaum","year":"1989","journal-title":"J Pediatr Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1242\/dev.02375","article-title":"Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling","volume":"133","author":"N Bondurand","year":"2006","journal-title":"Development"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ydbio.2006.01.032","article-title":"Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system","volume":"293","author":"N Nagy","year":"2006","journal-title":"Dev Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archsurg.1966.01320190003001","article-title":"Experimental obstructive colitis","volume":"92","author":"DJ Glotzer","year":"1966","journal-title":"Arch Surg"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0092-8674(94)90017-5","article-title":"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice","volume":"79","author":"K Hosoda","year":"1994","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0092-8674(94)90018-3","article-title":"Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons","volume":"79","author":"AG Baynash","year":"1994","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12519-009-0038-x","article-title":"Detection of intestinal bifidobacteria and lactobacilli in patients with Hirschsprung's disease associated enterocolitis","volume":"5","author":"D-H Shen","year":"2009","journal-title":"World J Pediatr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1172\/JCI3702","article-title":"Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease","volume":"102","author":"CE Gariepy","year":"1998","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00383-010-2586-5","article-title":"Genomics approach to the analysis of bacterial communities dynamics in Hirschsprung's disease-associated enterocolitis: a pilot study","volume":"26","author":"C De Filippo","year":"2010","journal-title":"Pediatr Surg Int"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/dvg.20415","article-title":"Targeting of endothelin receptor-B to the neural crest","volume":"46","author":"NR Druckenbrod","year":"2008","journal-title":"Genesis"},{"key":"ref38","article-title":"Sacral neural crest-derived cells enter the aganglionic colon of Ednrb(-\/-) mice along extrinsic nerve fibers","author":"CS Erickson","year":"2011","journal-title":"J Comp Neurol"},{"key":"ref39","article-title":"Altered neuronal density and neurotransmitter expression in the ganglionated region of Ednrb null mice: implications for Hirschsprung's disease","author":"I Zaitoun","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jpedsurg.2009.06.009","article-title":"Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system","volume":"45","author":"Z Cheng","year":"2010","journal-title":"J Pediatr Surg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1203\/00006450-198808000-00002","article-title":"Inflammatory response in enterocolitis in the piebald lethal mouse model of Hirschsprung's disease","volume":"24","author":"T Fujimoto","year":"1988","journal-title":"Pediatr Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1877-1173(10)92008-5","article-title":"Cellular and molecular requirements in lymph node and Peyer's patch development","volume":"92","author":"M Coles","year":"2010","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/mi.2007.6","article-title":"The immune geography of IgA induction and function","volume":"1","author":"AJ Macpherson","year":"2008","journal-title":"Mucosal Immunology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/gut.33.6.801","article-title":"Mucosal immune defence mechanisms in enterocolitis complicating Hirschsprung's disease","volume":"33","author":"A Imamura","year":"1992","journal-title":"Gut"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/mi.2009.15","article-title":"From the fetal liver to spleen and gut: the highway to natural antibody","volume":"2","author":"MM Rosado","year":"2009","journal-title":"Mucosal Immunology. Nature Publishing Group"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.4049\/jimmunol.177.9.6256","article-title":"Mechanisms of neonatal mucosal antibody protection","volume":"177","author":"NL Harris","year":"2006","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00383-010-2787-y","article-title":"Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis","volume":"27","author":"Z Cheng","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.20112422","article-title":"Essential role of EBF1 in the generation and function of distinct mature B cell types","volume":"209","author":"B Vilagos","year":"2012","journal-title":"Journal of Experimental Medicine"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/366695a0","article-title":"L-selectin-mediated lymphocyte rolling on MAdCAM-1","volume":"366","author":"EL Berg","year":"1993","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.190.1.75","article-title":"B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals","volume":"190","author":"F Loder","year":"1999","journal-title":"J Exp Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jneuroim.2007.01.014","article-title":"Anatomical evidence for enteric neuroimmune interactions in Peyer's patches","volume":"185","author":"L Vulchanova","year":"2007","journal-title":"J Neuroimmunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00302732","article-title":"Topography of the enteric nervous system in Peyer's patches of the porcine small intestine","volume":"272","author":"HJ Krammer","year":"1993","journal-title":"Cell Tissue Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00441-008-0583-y","article-title":"Anatomical evidence for ileal Peyer's patches innervation by enteric nervous system: a potential route for prion neuroinvasion?","volume":"332","author":"R Chiocchetti","year":"2008","journal-title":"Cell Tissue Res"},{"issue":"Pt 1","key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.1999.19510001.x","article-title":"The topography, architecture and structure of the enteric nervous system in the jejunum and ileum of cattle","volume":"195","author":"OB Balemba","year":"1999","journal-title":"J Anat"},{"issue":"Pt 2","key":"ref55","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1469-7580.1998.19220257.x","article-title":"The organisation of the enteric nervous system in the submucous and mucous layers of the small intestine of the pig studied by VIP and neurofilament protein immunohistochemistry","volume":"192","author":"OB Balemba","year":"1998","journal-title":"J Anat"},{"key":"ref56","article-title":"Characterization of Autonomic Nerve Markers and Lymphocyte Subsets in the Ileal Peyer's Patch of Pigs Infected Experimentally with Brachyspira hyodysenteriae","author":"J Kaleczyc","year":"2010","journal-title":"Journal of comparative pathology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0165-5728(03)00225-X","article-title":"Neuromodulation of enteropathogen internalization in Peyer's patches from porcine jejunum","volume":"141","author":"BT Green","year":"2003","journal-title":"J Neuroimmunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/immu.1994.1038","article-title":"The enteric nervous and immune systems: interactions for mucosal immunity and inflammation","volume":"5","author":"DW Pascual","year":"1994","journal-title":"Immunomethods"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/092986609787601642","article-title":"Uptake and dynamics of infectious prion protein in the intestine","volume":"16","author":"Y Ano","year":"2009","journal-title":"Protein Pept Lett"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"ra55","DOI":"10.1126\/scisignal.2002734","article-title":"Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems","volume":"5","author":"A Patel","year":"2012","journal-title":"Science Signaling"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.cellsig.2010.05.002","article-title":"Endothelin\u2014Biology and disease","volume":"22","author":"A-K Khimji","year":"2010","journal-title":"Cellular Signalling. Elsevier B.V"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1158\/1078-0432.CCR-08-0543","article-title":"Endothelin B Receptor, a New Target in Cancer Immune Therapy","volume":"15","author":"LE Kandalaft","year":"2009","journal-title":"Clinical Cancer Research"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1440-1746.2006.04822.x","article-title":"Experimental investigation of the role of endothelin-1 in idiopathic portal hypertension","volume":"22","author":"E Yamaguchi","year":"2007","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s000110050577","article-title":"Participation of endogenous endothelins in delayed eosinophil and neutrophil recruitment in mouse pleurisy","volume":"49","author":"AL Sampaio","year":"2000","journal-title":"Inflamm Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0024-3205(98)00165-9","article-title":"Endothelin-1, acting via the A receptor subtype, stimulates thymocyte proliferation in the rat","volume":"62","author":"LK Malendowicz","year":"1998","journal-title":"Life Sci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1182\/blood-2003-10-3559","article-title":"Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops","volume":"104","author":"G Guruli","year":"2004","journal-title":"Blood"},{"key":"ref67","first-page":"266","article-title":"Plasma levels of endothelin-1 in patients with Crohn's disease and ulcerative colitis","volume":"30","author":"C Letizia","year":"1998","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0140-6736(92)90077-G","article-title":"High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis","volume":"339","author":"SH Murch","year":"1992","journal-title":"The Lancet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0014-2999(96)00276-2","article-title":"An orally active non-selective endothelin receptor antagonist, bosentan, markedly reduces injury in a rat model of colitis","volume":"309","author":"CM Hogaboam","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00384-005-0015-3","article-title":"Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease","volume":"21","author":"C Anthoni","year":"2006","journal-title":"Int J Colorectal Dis"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.surg.2004.08.003","article-title":"l-selectin and alpha4beta7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice","volume":"137","author":"SR Reese","year":"2005","journal-title":"Surgery"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(93)90305-A","article-title":"Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1","volume":"74","author":"C Berlin","year":"1993","journal-title":"Cell"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nm1699","article-title":"Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy","volume":"14","author":"RJ Buckanovich","year":"2008","journal-title":"Nature Medicine"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0022-3468(97)90683-7","article-title":"Children with Hirschsprung's disease have an abnormal colonic mucus defensive barrier independent of the bowel innervation status","volume":"32","author":"A Aslam","year":"1997","journal-title":"J Pediatr Surg"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.coi.2004.03.005","article-title":"Regulation of IgA synthesis at mucosal surfaces","volume":"16","author":"S Fagarasan","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1309\/RV6E9BMC9954A2WU","article-title":"Spleen depletion in neonatal sepsis and chorioamnionitis","volume":"122","author":"P Toti","year":"2004","journal-title":"Am J Clin Pathol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:05:19Z","timestamp":1588964719000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128822"}},"subtitle":[],"editor":[{"given":"Anatoly V.","family":"Grishin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128822","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}