{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:31:20Z","timestamp":1790721080174,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128889","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T18:23:34Z","timestamp":1435256614000},"page":"e0128889","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":76,"title":["Effects of Tumour Necrosis Factor Antagonists on Insulin Sensitivity\/Resistance in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Agata N.","family":"Burska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalingham","family":"Sakthiswary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1002\/art.22053","article-title":"Insulin resistance and impaired beta cell function in rheumatoid arthritis","volume":"54","author":"PH Dessein","year":"2006","journal-title":"Arthritis & Rheumatism"},{"issue":"7\u20138","key":"ref2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.clinbiochem.2010.01.012","article-title":"Insulin resistance in early untreated rheumatoid arthritis patients","volume":"43","author":"D Shahin","year":"2010","journal-title":"Clinical biochemistry"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3132\/dvdr.2007.031","article-title":"Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis","volume":"4","author":"G La Montagna","year":"2007","journal-title":"Diabetes and Vascular Disease Research"},{"issue":"4","key":"ref4","first-page":"681","article-title":"Independent role of conventional cardiovascular risk factors as predictors of C-reactive protein concentrations in rheumatoid arthritis","volume":"34","author":"PH Dessein","year":"2007","journal-title":"J Rheumatol"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/art.23600","article-title":"Inflammation-associated insulin resistance: Differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms","volume":"58","author":"CP Chung","year":"2008","journal-title":"Arthritis & Rheumatism"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/acr.20414","article-title":"Diabetes mellitus and insulin resistance in patients with rheumatoid arthritis: Risk reduction in a chronic inflammatory disease","volume":"63","author":"MC Wasko","year":"2011","journal-title":"Arthritis care & research"},{"issue":"12","key":"ref7","first-page":"2447","article-title":"Role of insulin resistance in increased frequency of atherosclerosis detected by carotid ultrasonography in rheumatoid arthritis","volume":"33","author":"ON Pamuk","year":"2006","journal-title":"J Rheumatol"},{"issue":"3","key":"ref8","first-page":"462","article-title":"The acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis","volume":"29","author":"PH Dessein","year":"2002","journal-title":"J Rheumatol"},{"key":"ref9","first-page":"142","article-title":"Beyond the Joints in Rheumatoid Arthritis: Effects of Adalimumab on Hematologic and Lipid Indices","volume":"11","author":"R Sakthiswary","year":"2012","journal-title":"Excli Journal"},{"issue":"5249","key":"ref10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-\u03b1-and obesity-induced insulin resistance","volume":"271","author":"GS Hotamisligil","year":"1996","journal-title":"Science"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"R141","DOI":"10.1186\/ar3874","article-title":"Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance","volume":"14","author":"I Stagakis","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/0026-0495(79)90146-X","article-title":"Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations","volume":"28","author":"R Turner","year":"1979","journal-title":"Metabolism"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"A Katz","year":"2000","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"ref14","first-page":"1","article-title":"Surrogate measures of insulin sensitivity vs the hyperinsulinaemic\u2013euglycaemic clamp: a meta-analysis","author":"J Otten","year":"2014","journal-title":"Diabetologia"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"SP Hozo","year":"2005","journal-title":"BMC medical research methodology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"AR Jadad","year":"1996","journal-title":"Controlled clinical trials"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"R DerSimonian","year":"1986","journal-title":"Controlled clinical trials"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/ar3900","article-title":"Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis","volume":"14","author":"A Stavropoulos-Kalinoglou","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1055\/s-0031-1287783","article-title":"Systemic Blockade of TNF-\u03b1 does not Improve Insulin Resistance in Humans","volume":"43","author":"I Ferraz-Amaro","year":"2011","journal-title":"Hormone and Metabolic Research"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s10067-007-0539-8","article-title":"Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis","volume":"26","author":"S Tam L-","year":"2007","journal-title":"Clin Rheumatol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/03009740601179605","article-title":"Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNF\u03b1 therapy","volume":"36","author":"A Rosenvinge","year":"2007","journal-title":"Scand J Rheumatol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1179\/acb.2007.035","article-title":"The effect of infliximab treatment on insulin resistance in patients with rheumatoid arthritis","volume":"62","author":"F Oguz","year":"2007","journal-title":"Acta Clin Belg"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/ard.2004.026534","article-title":"Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis","volume":"64","author":"DN Kiortsis","year":"2005","journal-title":"Annals of the rheumatic diseases"},{"issue":"2","key":"ref24","first-page":"355","article-title":"Longterm anti-tumor necrosis factor-alpha treatment in patients with refractory rheumatoid arthritis: relationship between insulin resistance and disease activity","volume":"35","author":"B Seriolo","year":"2008","journal-title":"J Rheumatol"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1179\/acb.2007.035","article-title":"The effect of infliximab treatment on insulin resistance in patients with rheumatoid arthritis","volume":"62","author":"FM Oguz","year":"2007","journal-title":"Acta Clin Belg"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/ard.2004.026534","article-title":"Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis","volume":"64","author":"DN Kiortsis","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1055\/s-0031-1287783","article-title":"Systemic Blockade of TNF-\u03b1 does not Improve Insulin Resistance in Humans","volume":"43","author":"I Ferraz-Amaro","year":"2011","journal-title":"Horm Metab Res"},{"issue":"1","key":"ref28","first-page":"159","article-title":"Impact of long-term anti-TNF-alpha treatment on insulin resistance in patients with rheumatoid arthritis","volume":"26","author":"B Seriolo","year":"2008","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"ref29","first-page":"83","article-title":"Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis","volume":"24","author":"M Gonzalez-Gay","year":"2006","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.0954-6820.1983.tb03750.x","article-title":"Glucose intolerance in patients with chronic inflammatory diseases is normalized by glucocorticoids","volume":"213","author":"R H\u00e4llgren","year":"1983","journal-title":"Acta medica Scandinavica"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0026-0495(98)90005-1","article-title":"Impaired glucose handling in active rheumatoid arthritis: relationship to peripheral insulin resistance","volume":"37","author":"KL Svenson","year":"1988","journal-title":"Metabolism"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/0026-0495(91)90064-4","article-title":"Evidence for peripheral impaired glucose handling in patients with connective tissue diseases","volume":"40","author":"G Paolisso","year":"1991","journal-title":"Metabolism"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/acr.20657","article-title":"Diabetes mellitus risk in rheumatoid arthritis: Reduced incidence with anti\u2013tumor necrosis factor \u03b1 therapy","volume":"64","author":"A Bili","year":"2012","journal-title":"Arthritis care & research"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10067-009-1208-x","article-title":"Does TNF-alpha blockade play any role in cardiovascular risk among rheumatoid arthritis (RA) patients?","volume":"28","author":"R Cuchacovich","year":"2009","journal-title":"Clinical rheumatology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4236\/ojra.2013.33026","article-title":"Effect of Anti-TNF Therapy on Resistance to Insulin in Patients with Rheumatoid Arthritis","volume":"3","author":"M P\u00e9rez","year":"2013","journal-title":"Open Journal of Rheumatology and Autoimmune Diseases"},{"key":"ref36","article-title":"Effect of treatment with methotrexate and coal tar on adipokine levels and indices of insulin resistance and sensitivity in patients with psoriasis vulgaris","author":"M Rajappa","year":"2014","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diab.45.7.881","article-title":"Effects of an engineered human anti\u2013TNF-\u03b1 antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM","volume":"45","author":"F Ofei","year":"1996","journal-title":"Diabetes"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1046\/j.1463-1326.2002.00210.x","article-title":"Infliximab does not interfere with insulin secretion, insulin resistance and production of GAD and islet cell antibodies in patients with Crohn's disease","volume":"4","author":"S Gentile","year":"2002","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"3","key":"ref39","first-page":"1316","article-title":"No Increased Insulin Sensitivity after a Single Intravenous Administration of a Recombinant Human Tumor Necrosis Factor Receptor: Fc Fusion Protein in Obese Insulin-Resistant Patients 1","volume":"85","author":"N Paquot","year":"2000","journal-title":"The Journal of Clinical Endocrinology & Metabolism"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T18:31:30Z","timestamp":1566930690000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128889"}},"subtitle":[],"editor":[{"given":"Michael","family":"Nurmohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128889","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}