{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:48:53Z","timestamp":1790416133725,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0128941","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:52:04Z","timestamp":1433206324000},"page":"e0128941","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Breast Tissue Composition and Its Dependence on Demographic Risk Factors for Breast Cancer: Non-Invasive Assessment by Time Domain Diffuse Optical Spectroscopy"],"prefix":"10.1371","volume":"10","author":[{"given":"Paola","family":"Taroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Quarto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pifferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Balestreri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Menna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Cassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaldo","family":"Cubeddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10549-011-1727-4","article-title":"Tissue composition of mammographically dense and non-dense breast tissue","volume":"131","author":"K Ghosh","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1158\/1055-9965.EPI-05-0127","article-title":"The heritability of mammographically dense and nondense breast tissue","volume":"15","author":"J Stone","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa013390","article-title":"Heritability of mammographic density, a risk factor for breast cancer","volume":"347","author":"NF Boyd","year":"2002","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/jnci\/djq239","article-title":"Breast tissue composition and susceptibility to breast cancer","volume":"102","author":"NF Boyd","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1158\/1055-9965.EPI-06-0034","article-title":"Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk : A Meta-analysis","volume":"15","author":"VA Mccormack","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/bcr2942","article-title":"Mammographic density and breast cancer risk: current understanding and future prospects","volume":"13","author":"NF Boyd","year":"2011","journal-title":"Breast Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/bcr1829","article-title":"Mammographic density, breast cancer risk and risk prediction","volume":"9","author":"CM Vachon","year":"2007","journal-title":"Breast Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"076701","DOI":"10.1088\/0034-4885\/73\/7\/076701","article-title":"Diffuse optics for tissue monitoring and tomography","volume":"73","author":"T Durduran","year":"2010","journal-title":"Reports Prog Phys"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0031-9155\/50\/4\/R01","article-title":"Recent advances in diffuse optical imaging","volume":"50","author":"AP Gibson","year":"2005","journal-title":"Phys Med Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1098\/rsta.2009.0080","article-title":"Diffuse optical imaging","volume":"367","author":"A Gibson","year":"2009","journal-title":"Philos Trans A Math Phys Eng Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1117\/1.1695560","article-title":"Spatial variations in optical and physiological properties of healthy breast tissue","volume":"9","author":"N Shah","year":"2004","journal-title":"J Biomed Opt"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1117\/1.1691028","article-title":"Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes","volume":"9","author":"BW Pogue","year":"2004","journal-title":"J Biomed Opt"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1155\/2004\/460797","article-title":"The role of diffuse optical spectroscopy in the clinical management of breast cancer","volume":"19","author":"N Shah","year":"2004","journal-title":"Dis Markers"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"051704","DOI":"10.1117\/1.2098607","article-title":"Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo","volume":"10","author":"X Wang","year":"2005","journal-title":"J Biomed Opt"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1109\/3.328616","article-title":"Time-resolved reflectance: a systematic study for application to the optical characterization of tissues","volume":"30","author":"R Cubeddu","year":"1994","journal-title":"IEEE J Quantum Electron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"053103","DOI":"10.1063\/1.2735567","article-title":"Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media","volume":"78","author":"A Pifferi","year":"2007","journal-title":"Rev Sci Instrum"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1364\/OE.15.014482","article-title":"Portable, large-bandwidth time-resolved system for diffuse optical spectroscopy","volume":"15","author":"A Bassi","year":"2007","journal-title":"Opt Express"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1366\/000370209787169795","article-title":"Bandpass effects in time-resolved diffuse spectroscopy","volume":"63","author":"A Farina","year":"2009","journal-title":"Appl Spectrosc"},{"key":"ref19","first-page":"054030","article-title":"Diffuse optical spectroscopy of breast tissue extended to 1100 nm","volume":"14","author":"P Taroni","year":"2009","journal-title":"J Biomed Opt"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1364\/AO.36.000949","article-title":"Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms","volume":"36","author":"JR Mourant","year":"1997","journal-title":"Appl Opt"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1364\/AO.37.001256","article-title":"Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermotherapy","volume":"37","author":"AM Nilsson","year":"1998","journal-title":"Appl Opt"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"060501","DOI":"10.1117\/1.3506043","article-title":"Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy","volume":"15","author":"P Taroni","year":"2010","journal-title":"J Biomed Opt"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"060507","DOI":"10.1117\/1.JBO.18.6.060507","article-title":"Optical identification of subjects at high risk for developing breast cancer","volume":"18","author":"P Taroni","year":"2013","journal-title":"J Biomed Opt"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1364\/OE.17.015932","article-title":"Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification","volume":"17","author":"P Taroni","year":"2009","journal-title":"Opt Express"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1364\/AO.28.002331","article-title":"Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties","volume":"28","author":"MS Patterson","year":"1989","journal-title":"Appl Opt"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1364\/JOSAA.11.002727","article-title":"Boundary conditions for the diffusion equation in radiative transfer","volume":"11","author":"RC Haskell","year":"1994","journal-title":"J Opt Soc Am A Opt image Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1364\/OE.14.001888","article-title":"Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media","volume":"14","author":"C D\u2019Andrea","year":"2006","journal-title":"Opt Express"},{"key":"ref28","unstructured":"BI-RADS\u2014Mammography 2013\u2014American College of Radiology [Internet]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.acr.org\/quality-safety\/resources\/birads\/mammography\" xlink:type=\"simple\">http:\/\/www.acr.org\/quality-safety\/resources\/birads\/mammography<\/ext-link>. Accessed 2014 Jun 17."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2214\/ajr.167.5.8911192","article-title":"Analysis of parenchymal density on mammograms in 1353 women 25\u201379 years old","volume":"167","author":"PC Stomper","year":"1996","journal-title":"Am J Roentgenol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2214\/ajr.168.2.9016235","article-title":"Fatty and fibroglandular tissue volumes in the breasts of women 20\u201383 years old: comparison of X-ray mammography and computer-assisted MR imaging","volume":"168","author":"NA Lee","year":"1997","journal-title":"AJR Am J Roentgenol"},{"key":"ref31","first-page":"1048","article-title":"A Longitudinal Study of the Effects of Menopause on Mammographic Features","volume":"11","author":"N Boyd","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"W292","DOI":"10.2214\/AJR.10.6049","article-title":"The relationship of mammographic density and age: implications for breast cancer screening","volume":"198","author":"CM Checka","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1158\/1055-9965.EPI-04-0490","article-title":"The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer","volume":"14","author":"T Li","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1007\/s00330-012-2553-8","article-title":"Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI","volume":"22","author":"V King","year":"2012","journal-title":"Eur Radiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/db08-1098","article-title":"Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response","volume":"58","author":"M Pasarica","year":"2008","journal-title":"Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/bcr3228","article-title":"Height, adiposity and body fat distribution and breast density in young women","volume":"14","author":"JF Dorgan","year":"2012","journal-title":"Breast Cancer Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1470-2045(09)70078-6","article-title":"Breast-tissue composition and other risk factors for breast cancer in young women: a cross-sectional study","volume":"10","author":"N Boyd","year":"2009","journal-title":"Lancet Oncol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1006482418082","article-title":"Effects of Oral Contraceptives on Breast Epithelial Proliferation","volume":"65","author":"E Isaksson","year":"2001","journal-title":"Breast Cancer Res Treat"},{"key":"ref39","unstructured":"Anderson GL, Autier P, Beral V, Bosland MC, Fernandez E, Haslam SZ, et al. IWG on the E of CR to H. Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy [Internet]. Lyon; 2007. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/books.google.com\/books?hl=it&lr=&id=aGDU5xibtNgC&pgis=1\" xlink:type=\"simple\">http:\/\/books.google.com\/books?hl=it&amp;lr=&amp;id=aGDU5xibtNgC&amp;pgis=1<\/ext-link>"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2407-13-514","article-title":"Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast","volume":"13","author":"S Ueda","year":"2013","journal-title":"BMC Cancer"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7015-4-38","article-title":"Collagen reorganization at the tumor-stromal interface facilitates local invasion","volume":"4","author":"PP Provenzano","year":"2006","journal-title":"BMC Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1074\/jbc.M112.447631","article-title":"Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells","volume":"288","author":"CE Barcus","year":"2013","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.4172\/2157-2518.S13-007","article-title":"Aspects of Collagen Changes in Breast Cancer","volume":"S13","author":"C Luparello","year":"2013","journal-title":"J Carcinog Mutagen"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e100937","DOI":"10.1371\/journal.pone.0100937","article-title":"Evidence that breast tissue stiffness is associated with risk of breast cancer","volume":"9","author":"NF Boyd","year":"2014","journal-title":"PLoS One"},{"issue":"Suppl 8","key":"ref45","doi-asserted-by":"crossref","first-page":"viii37","DOI":"10.1093\/annonc\/mdt310","article-title":"Mammographic density, MRI background parenchymal enhancement and breast cancer risk","volume":"24","author":"MC Pike","year":"2013","journal-title":"Ann Oncol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1109\/JSTQE.2011.2177963","article-title":"Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy","volume":"18","author":"R Choe","year":"2012","journal-title":"IEEE J Sel Top Quantum Electron"},{"key":"ref47","article-title":"OT2-05-02: ACRIN 6691 Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using Diffuse Optical Spectroscopic Imaging (DOSI)","volume":"71","author":"B Tromberg","year":"2012","journal-title":"Cancer Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.2214\/AJR.07.2533","article-title":"Breast stromal enhancement on MRI is associated with response to neoadjuvant chemotherapy","volume":"190","author":"J Hattangadi","year":"2008","journal-title":"AJR Am J Roentgenol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1038\/bjc.2013.660","article-title":"Can shear-wave elastography predict response to neoadjuvant chemotherapy in women with invasive breast cancer?","volume":"109","author":"A Evans","year":"2013","journal-title":"Br J Cancer"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1186\/bcr3221","article-title":"Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast cancer","volume":"14","author":"J Kim","year":"2012","journal-title":"Breast Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0128941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T22:54:19Z","timestamp":1599087259000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0128941"}},"subtitle":[],"editor":[{"given":"Surinder K.","family":"Batra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,1]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0128941","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,1]]}}}