{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:46:25Z","timestamp":1782549985103,"version":"3.54.5"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129138","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T18:22:57Z","timestamp":1435256577000},"page":"e0129138","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Doxycycline Induces Apoptosis and Inhibits Proliferation and Invasion of Human Cervical Carcinoma Stem Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Binlie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"issue":"1","key":"ref1","first-page":"9","article-title":"Cancer statistics, 2014","volume":"64","author":"R Siegel","year":"2014","journal-title":"CA: a cancer journal for clinicians"},{"issue":"1","key":"ref2","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"R Siegel","year":"2012","journal-title":"CA: a cancer journal for clinicians"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s13277-013-1321-y","article-title":"Embryonic stem cell-specific signature in cervical cancer","volume":"35","author":"J Organista-Nava","year":"2014","journal-title":"Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"issue":"24","key":"ref4","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1158\/0008-5472.CAN-12-4704","article-title":"ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program","volume":"73","author":"E Charafe-Jauffret","year":"2013","journal-title":"Cancer research"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ccr.2013.02.021","article-title":"ROS links glucose metabolism to breast cancer stem cell and EMT phenotype","volume":"23","author":"MS Schieber","year":"2013","journal-title":"Cancer cell"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.stem.2008.07.012","article-title":"Cancer and stem cell biology: how tightly intertwined?","volume":"3","author":"CF Kim","year":"2008","journal-title":"Cell stem cell"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.stem.2008.03.014","article-title":"Cancer: inappropriate expression of stem cell programs?","volume":"2","author":"Y Wang","year":"2008","journal-title":"Cell stem cell"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/cgt.2011.58","article-title":"Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability","volume":"18","author":"W Gu","year":"2011","journal-title":"Cancer gene therapy"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.stem.2014.02.006","article-title":"Evolution of the cancer stem cell model","volume":"14","author":"A Kreso","year":"2014","journal-title":"Cell stem cell"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ccr.2006.12.007","article-title":"Hit &apos;em where they live: targeting the cancer stem cell niche","volume":"11","author":"ZJ Yang","year":"2007","journal-title":"Cancer cell"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/nat.2013.0423","article-title":"In vitro selection of modified RNA aptamers against CD44 cancer stem cell marker","volume":"23","author":"N Ababneh","year":"2013","journal-title":"Nucleic acid therapeutics"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1177\/030089161309900523","article-title":"Nuclear localization of cancer stem cell marker CD133 in triple-negative breast cancer: a case report","volume":"99","author":"M Cantile","year":"2013","journal-title":"Tumori"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"e357","DOI":"10.5301\/jbm.5000048","article-title":"Stem cell marker aldehyde dehydrogenase 1 (ALDH1)-expressing cells are enriched in triple-negative breast cancer","volume":"28","author":"H Li","year":"2013","journal-title":"The International journal of biological markers"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.3892\/ol.2013.1607","article-title":"Identification of a cancer stem cell-like side population in the HeLa human cervical carcinoma cell line","volume":"6","author":"K Wang","year":"2013","journal-title":"Oncology letters"},{"key":"ref15","article-title":"Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer","author":"Q Wang","year":"2013","journal-title":"Molecular carcinogenesis"},{"issue":"7","key":"ref16","first-page":"578","article-title":"Investigation on biological characteristics of CD133+ cancer stem cells in human laryngeal carcinoma Hep-2 cell line","volume":"48","author":"XD Wei","year":"2013","journal-title":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery"},{"issue":"38","key":"ref17","doi-asserted-by":"crossref","first-page":"16281","DOI":"10.1073\/pnas.0905653106","article-title":"Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment","volume":"106","author":"G Bertolini","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"e83971","DOI":"10.1371\/journal.pone.0083971","article-title":"Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells","volume":"8","author":"SS Chung","year":"2013","journal-title":"PloS one"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"pe12","DOI":"10.1126\/sageke.2006.9.pe12","article-title":"Stem cell aging and cancer","volume":"2006","author":"J Fuller","year":"2006","journal-title":"Science of aging knowledge environment: SAGE KE"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/labinvest.2011.72","article-title":"Functional characterization of osteosarcoma cell lines provides representative models to study the human disease","volume":"91","author":"AB Mohseny","year":"2011","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/bcr1855","article-title":"Brca1 breast tumors contain distinct CD44+\/CD24- and CD133+ cells with cancer stem cell characteristics","volume":"10","author":"MH Wright","year":"2008","journal-title":"Breast Cancer Research"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","article-title":"let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells","volume":"131","author":"F Yu","year":"2007","journal-title":"Cell"},{"issue":"17","key":"ref23","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1200\/JCO.2007.15.1829","article-title":"Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis","volume":"26","author":"CE Eyler","year":"2008","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"19","key":"ref24","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1016\/j.yexcr.2006.08.030","article-title":"SP analysis may be used to identify cancer stem cell populations","volume":"312","author":"A Hadnagy","year":"2006","journal-title":"Experimental Cell Research"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1167\/iovs.04-0288","article-title":"Sphere formation and expression of neural proteins by human corneal stromal cells in vitro","volume":"46","author":"S Uchida","year":"2005","journal-title":"Investigative ophthalmology & visual science"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2174\/187152010793498645","article-title":"Doxycycline in mitochondrial mediated pathway of apoptosis: a systematic review","volume":"10","author":"J Sagar","year":"2010","journal-title":"Anti-cancer agents in medicinal chemistry"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/01480545.2011.621954","article-title":"Genotoxic and cytotoxic effects of doxycycline in cultured human peripheral blood lymphocytes","volume":"35","author":"ZA Sekeroglu","year":"2012","journal-title":"Drug and chemical toxicology"},{"issue":"10","key":"ref28","first-page":"3995","article-title":"Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells","volume":"29","author":"K Son","year":"2009","journal-title":"Anticancer research"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/gt.2012.96","article-title":"Potential for enhanced therapeutic activity of biological cancer therapies with doxycycline combination","volume":"20","author":"H Tang","year":"2013","journal-title":"Gene therapy"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"e89841","DOI":"10.1371\/journal.pone.0089841","article-title":"The inhibitory effect of doxycycline on cisplatin-sensitive and-resistant epithelial ovarian cancer","volume":"9","author":"W Wu","year":"2014","journal-title":"PloS one"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ijc.22303","article-title":"Doxycycline induces caspase-dependent apoptosis in human pancreatic cancer cells","volume":"120","author":"PX Mouratidis","year":"2007","journal-title":"International journal of cancer Journal international du cancer"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1477-7819-7-2","article-title":"Does doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer?","volume":"7","author":"J Sagar","year":"2009","journal-title":"World journal of surgical oncology"},{"issue":"7","key":"ref33","first-page":"500","article-title":"Effects of endostatin and doxycycline on microcirculation patterns in melanoma and their relevant molecular mechanisms","volume":"29","author":"BC Sun","year":"2007","journal-title":"Zhonghua zhong liu za zhi [Chinese journal of oncology]"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0134201","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:31:58Z","timestamp":1589002318000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129138"}},"subtitle":[],"editor":[{"given":"Ruby John","family":"Anto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129138","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0134201","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}