{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:53:44Z","timestamp":1785927224394,"version":"3.56.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129246","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T17:39:47Z","timestamp":1434130787000},"page":"e0129246","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study"],"prefix":"10.1371","volume":"10","author":[{"given":"Ming-ming","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-ning","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-de","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-guo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-chen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-zhi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-min","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-chuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-guo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-hai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-tang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-lou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-guang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-shu","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-dan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-juan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-miao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-zhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-xiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-bing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-gang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"ref1","first-page":"9","article-title":"Cancer statistics","volume":"64","author":"R Siegel","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1016\/S1470-2045(13)70567-9","article-title":"Breast cancer in China","volume":"15","author":"L Fan","year":"2014","journal-title":"Lancet Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1186\/1471-2407-14-788","article-title":"Obesity is a significant risk factor for breast cancer in Arab women","volume":"14","author":"N Elkum","year":"2014","journal-title":"BMC Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e37784","DOI":"10.1371\/journal.pone.0037784","article-title":"The prevalence and correlates of breast cancer among women in Eastern China","volume":"7","author":"ZG Yu","year":"2012","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"s858","DOI":"10.1093\/ajcn\/86.3.858S","article-title":"Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence","volume":"86","author":"D Barb","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"258S","DOI":"10.3945\/ajcn.2009.28449C","article-title":"Adiponectin in insulin resistance: lessons from translational research","volume":"91","author":"F Ziemke","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11154-013-9265-5","article-title":"The role of adiponectin signaling in metabolic syndrome and cancer","volume":"15","author":"MP Scheid","year":"2014","journal-title":"Rev Endocr Metab Disord"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1210\/er.2011-1015","article-title":"The role of adiponectin in cancer: a review of current evidence","volume":"33","author":"M Dalamaga","year":"2012","journal-title":"Endocr Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1373\/clinchem.2007.085654","article-title":"Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid","volume":"53","author":"H Ebinuma","year":"2007","journal-title":"Clin Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1161\/01.RES.0000119921.86460.37","article-title":"Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin","volume":"94","author":"H Kobayashi","year":"2004","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"29359","DOI":"10.1074\/jbc.C200312200","article-title":"Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30)","volume":"277","author":"TS Tsao","year":"2002","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"T Kadowaki","year":"2005","journal-title":"Endocr Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1210\/jc.2004-0518","article-title":"Adiponectin: A novel adipokine linking adipocytes and vascular function","volume":"89","author":"BJ Goldstein","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1158\/0008-5472.CAN-07-2953","article-title":"T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model","volume":"68","author":"LW Hebbard","year":"2008","journal-title":"Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/ije\/dyu088","article-title":"Circulating adiponectin and breast cancer risk: a systematic review and meta-analysis","volume":"43","author":"D Macis","year":"2014","journal-title":"Int J Epidemiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e73183","DOI":"10.1371\/journal.pone.0073183","article-title":"The role of adiponectin in breast cancer: a meta-analysis","volume":"8","author":"LY Liu","year":"2013","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/CEJ.0b013e328364f293","article-title":"Circulating adiponectin levels and the risk of breast cancer: a meta-analysis","volume":"23","author":"J Ye","year":"2014","journal-title":"Eur J Cancer Prev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1074\/jbc.M310389200","article-title":"Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells","volume":"279","author":"N Ouchi","year":"2004","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/1097-0258(20000830)19:16<2115::AID-SIM529>3.0.CO;2-M","article-title":"Measuring the effectiveness of diagnostic markers in the presence of measurement error through the use of ROC curves","volume":"19","author":"B Reiser","year":"2000","journal-title":"Stat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.5551\/jat.No885","article-title":"Adiponectin and adiponectin receptors in human pheochromocytoma","volume":"16","author":"K Isobe","year":"2009","journal-title":"J Atheroscler Thromb"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"40352","DOI":"10.1074\/jbc.M300365200","article-title":"Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin","volume":"278","author":"H Waki","year":"2003","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"H Tilg","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e26840","DOI":"10.1371\/journal.pone.0026840","article-title":"Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection","volume":"6","author":"S Sumie","year":"2011","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.eururo.2008.02.044","article-title":"Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney","volume":"54","author":"JH Pinthus","year":"2008","journal-title":"Eur Urol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1210\/jc.2006-1858","article-title":"Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies","volume":"92","author":"A Korner","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s00125-005-1758-7","article-title":"Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males","volume":"48","author":"FM Fisher","year":"2005","journal-title":"Diabetologia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1074\/jbc.M311113200","article-title":"Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity","volume":"279","author":"UB Pajvani","year":"2004","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1210\/jc.2010-0716","article-title":"High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study","volume":"95","author":"N Zhu","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1210\/jc.2013-3222","article-title":"Effects of tomato and soy on serum adipokine concentrations in postmenopausal women at increased breast cancer risk: a cross-over dietary intervention trial","volume":"99","author":"AA Llanos","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/oby.2007.627","article-title":"Effects of pronounced weight loss on adiponectin oligomer composition and metabolic parameters","volume":"15","author":"J Engl","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s10552-009-9358-3","article-title":"Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors","volume":"20","author":"JA Ligibel","year":"2009","journal-title":"Cancer Causes Control"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T17:12:19Z","timestamp":1566839539000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129246"}},"subtitle":[],"editor":[{"given":"Seema","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129246","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]}}}