{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:06:16Z","timestamp":1773770776809,"version":"3.50.1"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129270","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T18:34:03Z","timestamp":1434393243000},"page":"e0129270","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Reciprocal Relationship between Head Size, an Autism Endophenotype, and Gene Dosage at 19p13.12 Points to AKAP8 and AKAP8L"],"prefix":"10.1371","volume":"10","author":[{"given":"Rebecca A.","family":"Nebel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Kirschen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Jae","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshi","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett S.","family":"Abrahams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"issue":"2","key":"ref1","first-page":"1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years\u2014autism and developmental disabilities monitoring network, 11 sites, United States, 2010","volume":"63","year":"2014","journal-title":"MMWR Surveill Summ"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"BS Abrahams","year":"2013","journal-title":"Mol Autism"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrg3585","article-title":"The role of de novo mutations in the genetics of autism spectrum disorders","volume":"15","author":"M Ronemus","year":"2014","journal-title":"Nat Rev Genet"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/archgenpsychiatry.2009.80","article-title":"Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation","volume":"66","author":"A Guilmatre","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/mp.2011.155","article-title":"QTL replication and targeted association highlight the nerve growth factor gene for nonverbal communication deficits in autism spectrum disorders","volume":"18","author":"AT-H Lu","year":"2013","journal-title":"Molecular Psychiatry"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1073\/pnas.1302985111","article-title":"Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills","volume":"111","author":"DH Skuse","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1601-183X.2011.00684.x","article-title":"CNTNAP2 variants affect early language development in the general population","volume":"10","author":"AJO Whitehouse","year":"2011","journal-title":"Genes, Brain and Behavior"},{"issue":"22","key":"ref8","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1056\/NEJMoa0802828","article-title":"A functional genetic link between distinct developmental language disorders","volume":"359","author":"SC Vernes","year":"2008","journal-title":"N Engl J Med"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajhg.2007.09.005","article-title":"Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene","volume":"82","author":"M Alarc\u00f3n","year":"2008","journal-title":"The American Journal of Human Genetics"},{"key":"ref10","first-page":"217","article-title":"Library of the History of Autism Research, Behaviorism &amp; Psychiatry","volume":"2","author":"L Kanner","year":"1943","journal-title":"Nervous Child"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1022903913547","article-title":"Brief report: cognitive correlates of enlarged head circumference in children with autism","volume":"33","author":"CK Deutsch","year":"2003","journal-title":"J Autism Dev Disord"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.biopsych.2013.04.018","article-title":"Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait","volume":"74","author":"P Chaste","year":"2013","journal-title":"Biological Psychiatry"},{"issue":"9067","key":"ref13","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0140-6736(05)62956-X","article-title":"Autism and macrocephaly","volume":"349","author":"RE Stevenson","year":"1997","journal-title":"Lancet"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/1096-8628(20001211)95:4<339::AID-AJMG9>3.0.CO;2-B","article-title":"Head circumference is an independent clinical finding associated with autism","volume":"95","author":"JH Miles","year":"2000","journal-title":"Am J Med Genet"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1023036509476","article-title":"Microcephaly and macrocephaly in autism","volume":"29","author":"E Fombonne","year":"1999","journal-title":"J Autism Dev Disord"},{"issue":"21","key":"ref16","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/ajmg.a.31465","article-title":"Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism","volume":"140","author":"JE Lainhart","year":"2006","journal-title":"Am J Med Genet"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.biopsych.2007.04.039","article-title":"Clinical, morphological, and biochemical correlates of head circumference in autism","volume":"62","author":"R Sacco","year":"2007","journal-title":"Biological Psychiatry"},{"issue":"1\u20132","key":"ref18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pneurobio.2005.10.005","article-title":"Macrocephaly and the control of brain growth in autistic disorders","volume":"77","author":"P McCaffery","year":"2005","journal-title":"Progress in Neurobiology"},{"issue":"11","key":"ref19","first-page":"923","article-title":"News and views","volume":"42","author":"B Wollnik","year":"2010","journal-title":"Nature Publishing Group. Nature Publishing Group"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/jmg.2004.024646","article-title":"Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations","volume":"42","author":"MG Butler","year":"2005","journal-title":"Journal of Medical Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/gim.2013.32","article-title":"Professional Practice and Guidelines Committee. Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: 2013 guideline revisions","author":"GB Schaefer","year":"2013","journal-title":"Genetics in medicine: official journal of the American College of Medical Genetics"},{"issue":"13","key":"ref22","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMoa052773","article-title":"Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2","volume":"354","author":"KA Strauss","year":"2006","journal-title":"N Engl J Med"},{"issue":"2","key":"ref23","first-page":"263","article-title":"Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development","volume":"158","author":"R Bernier","year":"2014","journal-title":"Cell. Elsevier Inc"},{"issue":"3","key":"ref24","first-page":"343","article-title":"Detection of copy-number variation in AUTS2gene by targeted exonic array CGH in patients with developmental delay and autistic spectrum disorders","volume":"21","author":"SCS Nagamani","year":"2012","journal-title":"Nature Publishing Group"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"e1003221","DOI":"10.1371\/journal.pgen.1003221","article-title":"Function and Regulation of AUTS2, a Gene Implicated in Autism and Human Evolution","volume":"9","author":"N Oksenberg","year":"2013","journal-title":"PLoS Genet"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/jmg.35.7.558","article-title":"Smith-Lemli-Opitz syndrome: a variable clinical and biochemical phenotype","volume":"35","author":"AK Ryan","year":"1998","journal-title":"Journal of Medical Genetics"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/jmg.2009.073015","article-title":"Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size","volume":"47","author":"M Shinawi","year":"2010","journal-title":"Journal of Medical Genetics"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/ng.279","article-title":"Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities","volume":"40","author":"N Brunetti-Pierri","year":"2008","journal-title":"Nat Genet"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ajhg.2010.10.004","article-title":"AR TICLEDeletion 17q12 Is a Recurrent Copy Number Variant that Confers High Risk of Autism and Schizophrenia","volume":"87","author":"D Moreno-De-Luca","year":"2010","journal-title":"The American Journal of Human Genetics. The American Society of Human Genetics"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/gim.2013.144","article-title":"22q13.2q13.32 genomic regions associated with severity of speech delay, developmental delay, and physical features in Phelan\u2013McDermid syndrome","volume":"16","author":"SM Sarasua","year":"2013","journal-title":"Genet Med"},{"issue":"14","key":"ref31","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"H Li","year":"2010","journal-title":"Bioinformatics"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"A McKenna","year":"2010","journal-title":"Genome Res"},{"issue":"5","key":"ref34","first-page":"491","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"MA DePristo","year":"2011","journal-title":"Nature Publishing Group"},{"key":"ref35","article-title":"A method and server for predicting damaging missense mutations","author":"IA Adzhubei","year":"2010","journal-title":"Nature"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nbt0804-1035","article-title":"Where did the BLOSUM62 alignment score matrix come from?","volume":"22","author":"SR Eddy","year":"2004","journal-title":"Nat Biotechnol"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1101\/gr.212802","article-title":"Accounting for human polymorphisms predicted to affect protein function","volume":"12","author":"PC Ng","year":"2002","journal-title":"Genome Res"},{"key":"ref38","article-title":"Prediction of deleterious human alleles","author":"S Sunyaev","year":"2001","journal-title":"Human molecular"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"e1003671","DOI":"10.1371\/journal.pgen.1003671","article-title":"Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes","volume":"9","author":"X He","year":"2013","journal-title":"PLoS Genet"},{"key":"ref40","article-title":"Head circumference reference data: birth to 18 years","author":"AF Roche","year":"1987","journal-title":"Head circumference reference data: birth to 18 years"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/adc.67.10.1286","article-title":"Centiles for adult head circumference","volume":"67","author":"KM Bushby","year":"1992","journal-title":"Archives of Disease in Childhood"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00001665-200401000-00042","article-title":"Development of a new three-dimensional cranial imaging system","volume":"15","author":"TR Littlefield","year":"2004","journal-title":"J Craniofac Surg"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1109\/TMI.2003.814784","article-title":"Estimating average growth trajectories in shape-space using kernel smoothing","volume":"22","author":"TJ Hutton","year":"2003","journal-title":"IEEE Trans Med Imaging"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1002\/ajmg.a.34286","article-title":"Pontocerebellar hypoplasia in association with de novo 19p13.11p13.12 microdeletion","volume":"155","author":"NM Gallant","year":"2011","journal-title":"Am J Med Genet"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1212\/01.wnl.0000256367.70365.e0","article-title":"DNA microarray analysis identifies candidate regions and genes in unexplained mental retardation","volume":"68","author":"H Engels","year":"2007","journal-title":"Neurology"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/ejhg.2010.115","article-title":"Genotype-phenotype relationship in three cases with overlapping 19p13.12 microdeletions","volume":"18","author":"MC Bonaglia","year":"2010","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejmg.2010.05.006","article-title":"A boy with mental retardation, obesity and hypertrichosis caused by a microdeletion of 19p13.12","volume":"53","author":"N Van der Aa","year":"2010","journal-title":"European Journal of Medical Genetics. Elsevier Masson SAS"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ejmg.2012.06.009","article-title":"A case of microdeletion of 19p13 with intellectual disability, hypertrichosis, synophrys, and protruding front teeth","volume":"55","author":"AM Jelsig","year":"2012","journal-title":"European Journal of Medical Genetics"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1002\/ajmg.a.33908","article-title":"Branchial arch defects and 19p13.12 microdeletion: Defining the critical region into a 0.8 M base interval","volume":"155","author":"K Kosaki","year":"2011","journal-title":"Am J Med Genet"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neuron.2011.05.002","article-title":"Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism","volume":"70","author":"SJ Sanders","year":"2011","journal-title":"Neuron. Elsevier Inc"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ajhg.2009.03.010","article-title":"DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources","volume":"84","author":"HV Firth","year":"2009","journal-title":"The American Journal of Human Genetics"},{"issue":"Database issue","key":"ref52","doi-asserted-by":"crossref","first-page":"D986","DOI":"10.1093\/nar\/gkt958","article-title":"The Database of Genomic Variants: a curated collection of structural variation in the human genome","volume":"42","author":"JR MacDonald","year":"2014","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ng.2250","article-title":"Identification of common variants associated with human hippocampal and intracranial volumes","volume":"44","author":"JL Stein","year":"2012","journal-title":"Nat Genet. Nature Publishing Group"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ng.2245","article-title":"Common variants at 6q22 and 17q21 are associated with intracranial volume","volume":"44","author":"MA Ikram","year":"2012","journal-title":"Nat Genet"},{"issue":"6679","key":"ref55","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/31940","article-title":"Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation","volume":"392","author":"P Billuart","year":"1998","journal-title":"Nature"},{"issue":"18","key":"ref56","doi-asserted-by":"crossref","first-page":"11754","DOI":"10.1073\/pnas.162241099","article-title":"The novel Rho-GTPase activating gene MEGAP\/srGAP3 has a putative role in severe mental retardation","volume":"99","author":"V Endris","year":"2002","journal-title":"Proc Natl Acad Sci USA. National Acad Sciences"},{"issue":"7304","key":"ref57","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09146","article-title":"Functional impact of global rare copy number variation in autism spectrum disorders","volume":"466","author":"D Pinto","year":"2010","journal-title":"Nature"},{"issue":"86","key":"ref58","doi-asserted-by":"crossref","first-page":"86ra49","DOI":"10.1126\/scitranslmed.3002166","article-title":"Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders","volume":"3","author":"Y Sakai","year":"2011","journal-title":"Science Translational Medicine"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2346","article-title":"Advances in autism genetics: on the threshold of a new neurobiology","volume":"9","author":"BS Abrahams","year":"2008","journal-title":"Nat Rev Genet"},{"key":"ref60","first-page":"699","article-title":"Genetics of autism","author":"BS Abrahams","year":"2010"},{"key":"ref61","unstructured":"Exome Aggregation Consortium (ExAC), Cambridge, MA (URL: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/exac.broadinstitute.org\" xlink:type=\"simple\">http:\/\/exac.broadinstitute.org<\/ext-link>) [9 December 2014]."},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00019052-200104000-00003","article-title":"Molecular genetics of human microcephaly","volume":"14","author":"GH Mochida","year":"2001","journal-title":"Current Opinion in Neurology"},{"key":"ref63","article-title":"Genetic disorders associated with macrocephaly","author":"CA Williams","year":"2008","journal-title":"Journal of Medical Genetics"},{"key":"ref64","article-title":"Genes that control the size of the cerebral cortex","author":"TH Chae","year":"2007","journal-title":"Cortical development: genes and genetic \u2026"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1083\/jcb.147.6.1167","article-title":"The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis","volume":"147","author":"P Collas","year":"1999","journal-title":"The Journal of Cell Biology"},{"issue":"Pt 21","key":"ref66","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1242\/jcs.113.21.3703","article-title":"HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics","volume":"113","author":"SB Martins","year":"2000","journal-title":"Journal of Cell Science"},{"issue":"Pt 2","key":"ref67","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1042\/bj20031765","article-title":"A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95","volume":"378","author":"T Arsenijevic","year":"2004","journal-title":"Biochem J"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.4161\/cc.5.11.2802","article-title":"G1\/S Cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95","volume":"5","author":"T Arsenijevic","year":"2006","journal-title":"Cell Cycle"},{"issue":"29","key":"ref69","doi-asserted-by":"crossref","first-page":"26750","DOI":"10.1074\/jbc.M300765200","article-title":"Protein Kinase A-anchoring Protein AKAP95 Interacts with MCM2, a Regulator of DNA Replication","volume":"278","author":"T Eide","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"18","key":"ref70","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1101\/gad.1455006","article-title":"A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity","volume":"20","author":"Y Li","year":"2006","journal-title":"Genes & Development"},{"key":"ref71","unstructured":"BrainSpan: Atlas of the Developing Human Brain [Internet]. Funded by ARRA Awards 1RC2MH089921-01, 1RC2MH090047-01, and 1RC2MH089929-01. \u00a9 2011. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/developinghumanbrain.org\" xlink:type=\"simple\">http:\/\/developinghumanbrain.org<\/ext-link>."},{"issue":"18","key":"ref72","doi-asserted-by":"crossref","first-page":"14644","DOI":"10.1074\/jbc.M111.261875","article-title":"Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity","volume":"287","author":"A Al-Tawashi","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1038\/tp.2013.48","article-title":"AKAPs integrate genetic findings for autism spectrum disorders","volume":"3","author":"G Poelmans","year":"2013","journal-title":"Transl Psychiatry"},{"issue":"5","key":"ref74","first-page":"399","article-title":"A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. Hum Genet","volume":"105","author":"H Chen","year":"1999","journal-title":"A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. Hum Genet"},{"issue":"24","key":"ref75","doi-asserted-by":"crossref","first-page":"21745","DOI":"10.1074\/jbc.M101480200","article-title":"PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase","volume":"276","author":"Y Wu","year":"2001","journal-title":"J Biol Chem"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81663-3","article-title":"Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association","volume":"99","author":"JO Lee","year":"1999","journal-title":"Cell"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T09:33:01Z","timestamp":1652434381000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129270"}},"subtitle":[],"editor":[{"given":"Masako","family":"Taniike","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129270","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}