{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:58:54Z","timestamp":1778914734946,"version":"3.51.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129291","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T19:11:02Z","timestamp":1433531462000},"page":"e0129291","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Vitamin D Binding Protein Isoforms and Apolipoprotein E in Cerebrospinal Fluid as Prognostic Biomarkers of Multiple Sclerosis"],"prefix":"10.1371","volume":"10","author":[{"given":"Simona","family":"Perga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Giuliano Albo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Lis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Minari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Falvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Marnetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Caldano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Reviglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Berchialla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Capobianco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Malentacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Corpillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Bertolotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1474-4422(13)70233-3","article-title":"Body fluid biomarkers in multiple sclerosis","volume":"13","author":"M Comabella","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ymeth.2013.04.008","article-title":"Recent advances in quantitative neuroproteomics","volume":"61","author":"GE Craft","year":"2013","journal-title":"Methods"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/B978-0-444-52001-2.00029-7","article-title":"Cerebrospinal fluid analysis","volume":"122","author":"G Giovannoni","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1212\/WNL.0b013e3181c47cc2","article-title":"A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking","volume":"73","author":"CE Teunissen","year":"2009","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1177\/1352458513488232","article-title":"Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis","volume":"19","author":"C Teunissen","year":"2013","journal-title":"Mult Scler"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10571-008-9312-z","article-title":"Alteration of DBP levels in CSF of patients with MS by proteomics analysis","volume":"29","author":"Z Qin","year":"2008","journal-title":"Cellular and Molecular Neurobiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1177\/1352458507076406","article-title":"Cerebrospinal fluid proteome profile in multiple sclerosis","volume":"13","author":"V Lehmensiek","year":"2007","journal-title":"Mult Scler"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0012442","article-title":"Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis","volume":"5","author":"MP Stoop","year":"2010","journal-title":"PlosOne"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jprot.2014.04.028","article-title":"Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset","volume":"106","author":"D Chiasserini","year":"2014","journal-title":"J Proteomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neulet.2009.01.057","article-title":"CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis","volume":"452","author":"H Tumani","year":"2009","journal-title":"Neuroscience Letters"},{"key":"ref11","first-page":"9","article-title":"Proteomic profiling in multiple sclerosis clinical courses reveals potential biomarkers of neurodegeneration","volume":"6","author":"M Liguori","year":"2014","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jprot.2010.01.004","article-title":"Multiple sclerosis: identification and clinical evaluation of novel CSF biomarkers","volume":"73","author":"J Ottervald","year":"2010","journal-title":"Journal of Proteomics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1177\/1352458511399614","article-title":"Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometry","volume":"17","author":"CE Teunissen","year":"2011","journal-title":"Mult Scler"},{"key":"ref14","unstructured":"Bertolotto A, Malentacchi M, Capobianco M, Di Sapio A, Malucchi S, Motuzova Y, et al. (2015) Post-dural puncture headache is markedly reduced when 25 Sprotte needles are used. Cephalalgia Epub ahead of print."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"","volume":"58","author":"CH Polman","year":"2005","journal-title":"Ann Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1002\/elps.201000171","article-title":"Acute-phase proteins investigation based on lectins affinity capture prior to 2-DE separation: application to serum from multiple sclerosis patients","volume":"17","author":"A Robotti","year":"2010","journal-title":"Electrophoresis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1002\/pmic.200500021","article-title":"Development of a simplified, economical polyacrylamide gel staining protocol for phosphoproteins","volume":"5","author":"GK Agrawal","year":"2005","journal-title":"Proteomics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2217\/bmm.09.4","article-title":"Lymphocyte proteomics of Parkinson\u2019s disease patients reveals cytoskeletal protein dysregulation and oxidative stress","volume":"3","author":"S Mila","year":"2009","journal-title":"Biomarkers Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"J Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1155\/2006\/158797","article-title":"Protein analysis in human cerebrospinal fluid: physiological aspects, current progress and further challenges","volume":"22","author":"AF H\u00fchmer","year":"2006","journal-title":"Disease markers"},{"key":"ref21","unstructured":"Eriksson B, Franzen B, Ottervald J (2008) Method for diagnosing Multiple Sclerosis. US2008171394."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jprot.2010.11.010","article-title":"Proteomics of human cerebrospinal fluid: discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics","volume":"74","author":"AC Kroksveen","year":"2011","journal-title":"J Proteomics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jneuroim.2013.09.003","article-title":"The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis","volume":"264","author":"M Axelsson","year":"2013","journal-title":"J Neuroimmunol"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1352458513500552","article-title":"Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis","volume":"20","author":"J Smolders","year":"2013","journal-title":"Mult Scler"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1600-0404.2011.01622.x","article-title":"Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: a head-to-head retrospective study","volume":"126","author":"R Lanzillo","year":"2012","journal-title":"Acta Neurol Scand"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1742-1241.2011.02721.x","article-title":"Oral fingolimod for the treatment of patients with relapsing forms of multiple sclerosis","volume":"65","author":"B Singer","year":"2012","journal-title":"Int J Clin Pract"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/cbf.2835","article-title":"New perspectives on the vitamin D binding protein","volume":"30","author":"RF Chun","year":"2012","journal-title":"Cell Biochem Funct"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/ane.12029","article-title":"Cerebrospinal fluid proteome comparison between multiple sclerosis patients and controls","volume":"195","author":"AC Kroksveen","year":"2012","journal-title":"Acta Neurol Scand Suppl"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00415-010-5797-8","article-title":"The emerging role of vitamin D binding protein in multiple sclerosis","volume":"258","author":"G Disanto","year":"2010","journal-title":"J Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell\u2014mediated immune mechanisms in multiple sclerosis","volume":"476","author":"S Sawcer","year":"2011","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1468-1331.2008.02133.x","article-title":"Gelsolin concentration in cerebrospinal fluid from patients with multiple sclerosis and other neurological disorders","volume":"15","author":"A Kulakowska","year":"2009","journal-title":"European Journal of Neurology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-2377-10-107","article-title":"Hypogelsolinemia, a disorder of the extracellular actin scavenger system, in patients with multiple sclerosis","volume":"10","author":"A Kulakowska","year":"2010","journal-title":"BMC Neurology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s12035-012-8387-1","article-title":"Vitamin D-binding protein in cerebrospinal fluid is associated with multiple sclerosis progression","volume":"47","author":"M Yang","year":"2013","journal-title":"Mol Neurobiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/pro.214","article-title":"Glycosylation status of vitamin D binding protein in cancer patients","volume":"18","author":"DS Rehder","year":"2009","journal-title":"Protein Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.bbapap.2009.12.022","article-title":"The glycosylation and characterization of the candidate Gc macrophage activating factor","volume":"1804","author":"T Ravnsborg","year":"2010","journal-title":"Biochimica and Biophysica Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jsbmb.2013.09.012","article-title":"Vitamin D and DBP: the free hormone hypothesis revisited","volume":"144","author":"RF Chun","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1016\/j.jprot.2012.06.024","article-title":"Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis","volume":"75","author":"DS Gibson","year":"2012","journal-title":"J Proteomics"},{"key":"ref38","first-page":"45","article-title":"Effects of vitamin D-binding protein-derived macrophage-activating factor on human breast cancer cells","volume":"32","author":"S Pacini","year":"2012","journal-title":"Anticancer Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00223-004-0227-5","article-title":"Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women","volume":"77","author":"AL Lauridsen","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/clinchem\/47.4.753","article-title":"Mean serum concentration of vitamin D-binding protein (Gc globulin) is related to the Gc phenotype in women","volume":"47","author":"AL Lauridsen","year":"2001","journal-title":"Clin Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3945\/ajcn.113.080309","article-title":"Genome-wide association study of circulating vitamin D-binding protein","volume":"99","author":"KA Moy","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"ref42","first-page":"1122","article-title":"Association of apolipoprotein E genotypes with prognosis in multiple sclerosis","volume":"15","author":"Y Tamam","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T03:01:39Z","timestamp":1599102099000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129291"}},"subtitle":[],"editor":[{"given":"Heinz","family":"Wiendl","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,5]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129291","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,5]]}}}