{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:53:19Z","timestamp":1792511599757,"version":"4.5.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129305","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T17:37:04Z","timestamp":1438623424000},"page":"e0129305","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":252,"title":["Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Tomer","family":"Avni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Lador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaul","family":"Lev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Leibovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mical","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1164\/rccm.2201087","article-title":"Current epidemiology of septic shock: the CUB-Rea Network","volume":"168","author":"D Annane","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"DC Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1097\/00003246-199812000-00045","article-title":"Has the mortality of septic shock changed with time","volume":"26","author":"G Friedman","year":"1998","journal-title":"Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","article-title":"definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"20","year":"1992","journal-title":"Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"E Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/SHK.0b013e3181971d47","article-title":"Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis","volume":"32","author":"RC Arnold","year":"2009","journal-title":"Shock"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1097\/01.CCM.0000139761.05492.D6","article-title":"Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update","volume":"32","author":"SM Hollenberg","year":"2004","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.CCM.0000117317.18092.E4","article-title":"Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock","volume":"32","author":"RP Dellinger","year":"2004","journal-title":"Crit Care Med"},{"key":"ref9","article-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]","author":"JPT Higgins","year":"2008"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"SP Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/1658-354X.82784","article-title":"Comparative study of dopamine and norepinephrine in the management of septic shock","volume":"5","author":"A Agrawal","year":"2011","journal-title":"Saudi J Anaesth"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1097\/01.CCM.0000178182.37639.D6","article-title":"Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study","volume":"33","author":"J Albanese","year":"2005","journal-title":"Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0140-6736(07)61344-0","article-title":"Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial","volume":"370","author":"D Annane","year":"2007","journal-title":"Lancet"},{"key":"ref14","first-page":"565","article-title":"Comparisom of the effect and complication between dopaimne and norepinephrine on treatment of the septic shock","volume":"47","author":"H Chen","year":"2012","journal-title":"Jiangxi Medical Journal"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1056\/NEJMoa0907118","article-title":"Comparison of dopamine and norepinephrine in the treatment of shock","volume":"362","author":"D De Backer","year":"2010","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/01.CCM.0000063045.77339.B6","article-title":"Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?","volume":"31","author":"D De Backer","year":"2003","journal-title":"Crit Care Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/00003246-199905000-00021","article-title":"Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock","volume":"27","author":"J Duranteau","year":"1999","journal-title":"Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.shk.0000150549.45338.6c","article-title":"Effects of dopamine and norepinephrine on systemic and hepatosplanchnic hemodynamics, oxygen exchange, and energy balance in vasoplegic septic patients","volume":"23","author":"JP Guerin","year":"2005","journal-title":"Shock"},{"key":"ref19","first-page":"1188","article-title":"Impact of Dopamine and norepinephrine on renal perfusion in patients with septic shock","volume":"30","author":"K High","year":"2008","journal-title":"Journal of Hebei Medicine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/0972-5229.63033","article-title":"Comparison of phenylephrine and norepinephrine in the management of dopamine-resistant septic shock","volume":"14","author":"G Jain","year":"2010","journal-title":"Indian J Crit Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s00134-006-0378-0","article-title":"Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial","volume":"32","author":"F Lauzier","year":"2006","journal-title":"Intensive Care Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s001340050329","article-title":"Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study","volume":"23","author":"B Levy","year":"1997","journal-title":"Intensive Care Med"},{"key":"ref23","first-page":"265","article-title":"Comparison evaluation of resuscitation effect of norepinephrine and dopamine on the treatment of septic shock","volume":"8","author":"P Liu","year":"2010","journal-title":"Clinical Education of General Practice"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00005373-199910000-00014","article-title":"Low-dose vasopressin in the treatment of vasodilatory septic shock","volume":"47","author":"MB Malay","year":"1999","journal-title":"J Trauma"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1001\/jama.1994.03520170064037","article-title":"The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis","volume":"272","author":"PE Marik","year":"1994","journal-title":"JAMA"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/0972-5229.37713","article-title":"Comparison of norepinephrine and dopamine in the management of septic shock using impedance cardiography","volume":"11","author":"K Marthur","year":"2007","journal-title":"Indian J Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1378\/chest.103.6.1826","article-title":"Norepinephrine or dopamine for the treatment of hyperdynamic septic shock?","volume":"103","author":"C Martin","year":"1993","journal-title":"Chest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"R217","DOI":"10.1186\/cc10453","article-title":"Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock","volume":"15","author":"A Morelli","year":"2011","journal-title":"Crit Care"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"R130","DOI":"10.1186\/cc7990","article-title":"Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study","volume":"13","author":"A Morelli","year":"2009","journal-title":"Crit Care"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1186\/cc7121","article-title":"Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial","volume":"12","author":"A Morelli","year":"2008","journal-title":"Crit Care"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1007\/s00134-008-1219-0","article-title":"A comparison of epinephrine and norepinephrine in critically ill patients","volume":"34","author":"JA Myburgh","year":"2008","journal-title":"Intensive Care Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000542-200203000-00011","article-title":"Beneficial effects of short-term vasopressin infusion during severe septic shock","volume":"96","author":"BM Patel","year":"2002","journal-title":"Anesthesiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/SHK.0b013e3181c6ba6f","article-title":"Efficacy and safety of dopamine versus norepinephrine in the management of septic shock","volume":"33","author":"GP Patel","year":"2010","journal-title":"Shock"},{"key":"ref34","first-page":"47","article-title":"Use of vasopressin to correct hemodynamic disorders in patients with abdominal sepsis","author":"LL Plotkin","year":"2007","journal-title":"Anesteziol Reanimatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1097\/00003246-199309000-00011","article-title":"Regional blood flow and oxygen transport in septic shock","volume":"21","author":"E Ruokonen","year":"1993","journal-title":"Crit Care Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa067373","article-title":"Vasopressin versus norepinephrine infusion in patients with septic shock","volume":"358","author":"JA Russell","year":"2008","journal-title":"N Engl J Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1378\/chest.95.6.1282","article-title":"Effect of dopamine vs norepinephrine on hemodynamics in septic shock. Emphasis on right ventricular performance","volume":"95","author":"WO Schreuder","year":"1989","journal-title":"Chest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1067\/mcp.2002.122471","article-title":"Effects of epinephrine compared with the combination of dobutamine and norepinephrine on gastric perfusion in septic shock","volume":"71","author":"P Seguin","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"ref39","first-page":"1043","article-title":"Terlipressin in the treatment of late phase catecholamine-resistant septic shock","volume":"59","author":"P Svoboda","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"ref40","first-page":"117","article-title":"Effect of dopamine and norepinephrine on hemodynamics and oxygen metabolism of tissue in patients with septic shock","volume":"4","author":"J Wu","year":"2010","journal-title":"Chin Arch Gen Surg (Electronic Edition)"},{"key":"ref41","first-page":"654","article-title":"Effects of norepinephrine, epinephrine, and norepinephrine-dobutamine on systemic and gastric mucosal oxygenation in septic shock","volume":"23","author":"SX Zhou","year":"2002","journal-title":"Acta Pharmacol Sin"},{"key":"ref42","first-page":"93","article-title":"Affect of norepinephrine and dopamine on infectious tissue oxygen metabolism and hemodynamics in patients with shock","volume":"51","author":"Y Zhuangyu","year":"2011","journal-title":"Shandong Medicine Journal"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock","volume":"370","author":"CI Pro","year":"2014","journal-title":"N Engl J Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1097\/01.CCM.0000063046.82359.4A","article-title":"Circulating vasopressin levels in septic shock","volume":"31","author":"T Sharshar","year":"2003","journal-title":"Crit Care Med"},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003709.pub3","article-title":"Vasopressors for hypotensive shock","volume":"5","author":"C Havel","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/CCM.0b013e31823778ee","article-title":"Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*","volume":"40","author":"D De Backer","year":"2012","journal-title":"Crit Care Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/0885066610396312","article-title":"Norephinephrine or Dopamine for Septic Shock: A Systematic Review of Randomized Clinical Trials","volume":"27","author":"TS Vasu","year":"2011","journal-title":"J Intensive Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T17:36:38Z","timestamp":1540229798000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129305"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Landoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,3]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129305","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,3]]}}}