{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:25:14Z","timestamp":1779139514164,"version":"3.51.4"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129432","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T18:18:17Z","timestamp":1434392297000},"page":"e0129432","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differentially Expressed Genes in EEC and LMS Syndromes"],"prefix":"10.1371","volume":"10","author":[{"given":"Wei","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangge","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuan","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1525-1470.2009.00976.x","article-title":"A case of ankyloblepharon, ectodermal dysplasia, and cleft lip\/palate syndrome with ectrodactyly: are the p63 syndromes distinct after all?","volume":"28","author":"YE Chiu","year":"2011","journal-title":"Pediatr Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2133.2010.09859.x","article-title":"Rapp-Hodgkin and Hay-Wells ectodermal dysplasia syndromes represent a variable spectrum of the same genetic disorder","volume":"163","author":"SE Clements","year":"2010","journal-title":"Br J Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1525-1470.2010.01131.x","article-title":"ADULT syndrome caused by a mutation previously associated with EEC syndrome","volume":"27","author":"E Avitan-Hersh","year":"2010","journal-title":"Pediatr Dermatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e35337","DOI":"10.1371\/journal.pone.0035337","article-title":"Analysis of large phenotypic variability of EEC and SHFM4 syndromes caused by K193E mutation of the TP63 gene","volume":"7","author":"J Wei","year":"2012","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.0009-9163.2004.00278.x","article-title":"Molecular evidence that AEC syndrome and Rapp\u2013Hodgkin syndrome are variable expression of a single genetic disorder","volume":"66","author":"DR Bertola","year":"2004","journal-title":"Clin Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jmg.39.6.377","article-title":"The TP63 gene in EEC and other syndromes","volume":"39","author":"HG Brunner","year":"2002","journal-title":"J Med Genet"},{"key":"ref7","unstructured":"The National Center for Biotechnology Information. TP63 tumor protein p63 [Homo sapiens<\/italic> (human)]. 2015. Available: http:\/\/www.ncbi.nlm.nih.gov\/gene?cmd=retrieve&dopt=full_report&list_uids=8626<\/ext-link>."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/ajmg.a.32793","article-title":"Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon\u2013ectodermal defects\u2013cleft lip \u2044 palate syndrome (AEC)","volume":"149","author":"T Rinne","year":"2009","journal-title":"Am J Med Genet A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1136\/jmg.40.12.e133","article-title":"Rapp\u2013Hodgkin and AEC syndromes due to a new frameshift mutation in the TP63 gene","volume":"40","author":"I Dianzani","year":"2003","journal-title":"J Med Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1525-1470.2005.00105.x","article-title":"Spectrum of phenotypic manifestations from a single point mutation of the p63 gene, including new cutaneous and immunologic findings","volume":"22","author":"JA Steele","year":"2005","journal-title":"Pediatr Dermatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/ajmg.a.31187","article-title":"Rapp-Hodgkin ectodermal dysplasia syndrome: the clinical and molecular overlap with Hay-Wells syndrome","volume":"149A","author":"P Kannu","year":"2006","journal-title":"Am J Med Genet A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2133.1994.tb06891.x","article-title":"Rapp\u2013Hodgkin and AEC syndrome: are they the same entity?","volume":"130","author":"S Cambiaghi","year":"1994","journal-title":"Br J Dermatol"},{"key":"ref13","first-page":"397","article-title":"An intermediate phenotype between Hay\u2013Wells and Rapp\u2013Hodgkin syndromes in a patient with a novel P63 mutation: confirmation of a variable phenotypic spectrum with a common aetiology","volume":"19","author":"P Prontera","year":"2008","journal-title":"Genet Couns"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/0022034510366804","article-title":"TP63 gene mutations in Chinese P63 syndrome patients","volume":"89","author":"W Yin","year":"2010","journal-title":"J Dent Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10549-006-9385-7","article-title":"Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients","volume":"103","author":"Y Feng","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e35337","DOI":"10.1371\/journal.pone.0035337","article-title":"Analysis of Large Phenotypic Variability of EEC and SHFM4 Syndromes Caused by K193E Mutation of the TP63 Gene","volume":"7","author":"J Wei","year":"2012","journal-title":"PLoS One"},{"key":"ref17","first-page":"57","article-title":"Role of p63 in cancer development","volume":"1816","author":"V Graziano","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00432-012-1200-8","article-title":"Overexpression and ratio disruption of \u0394Np63 and TAp63 isoform equilibrium in endometrialadenocarcinoma: correlation with obesity, menopause, and grade I\/II tumors","volume":"138","author":"E Vakonaki","year":"2012","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref19","first-page":"2351","article-title":"DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development","volume":"63","author":"G Wu","year":"2003","journal-title":"Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:51:55Z","timestamp":1589046715000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129432"}},"subtitle":[],"editor":[{"given":"Tao","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129432","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}