{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:25:25Z","timestamp":1791221125587,"version":"4.1.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129618","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T18:11:10Z","timestamp":1434651070000},"page":"e0129618","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":96,"title":["Cannabinoid CB2 Receptors in a Mouse Model of A\u03b2 Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation"],"prefix":"10.1371","volume":"10","author":[{"given":"Alena V.","family":"Savonenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Melnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Ravert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Koppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deidre","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pletnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuzhat","family":"Sayyida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hiatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Troncoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Dannals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Pomper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Horti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/NRL.0b013e31826a998d","article-title":"New criteria for Alzheimer disease and mild cognitive impairment: implications for the practicing clinician","volume":"18","author":"AE Budson","year":"2012","journal-title":"Neurologist"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"G McKhann","year":"1984","journal-title":"Neurology"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"GM McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"ref4","article-title":"The Neuropathology of Dementia","author":"GH Morris","year":"2004"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"RA Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"RJ Bateman","year":"2012","journal-title":"N Engl J Med"},{"issue":"7179","key":"ref7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature06616","article-title":"Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease","volume":"451","author":"M Meyer-Luehmann","year":"2008","journal-title":"Nature"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"a006346","DOI":"10.1101\/cshperspect.a006346","article-title":"Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature","volume":"2","author":"T Wyss-Coray","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2013.06.046","article-title":"Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease","volume":"79","author":"KM Lucin","year":"2013","journal-title":"Neuron"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.bjp.0707505","article-title":"Cannabinoid CB2 receptors in human brain inflammation","volume":"153","author":"C Benito","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.expneurol.2010.03.024","article-title":"The endocannabinoid system and amyloid-related diseases","volume":"224","author":"L Ruiz-Valdepenas","year":"2010","journal-title":"Exp Neurol"},{"key":"ref12","first-page":"249","article-title":"PET and SPECT of Neurobiological Systems","author":"AG Horti","year":"2014"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Latta CH, Brothers HM, Wilcock DM. Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy. Neuroscience. 2014. doi: 10.1016\/j.neuroscience.2014.09.061<\/ext-link><\/comment> 25286385<\/object-id>.","DOI":"10.1016\/j.neuroscience.2014.09.061"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.nucmedbio.2011.09.005","article-title":"Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer","volume":"39","author":"N Evens","year":"2012","journal-title":"Nucl Med Biol"},{"issue":"15","key":"ref15","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1016\/j.bmc.2011.06.033","article-title":"Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging","volume":"19","author":"N Evens","year":"2011","journal-title":"Bioorg Med Chem"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2967\/jnumed.110.084426","article-title":"A PET brain reporter gene system based on type 2 cannabinoid receptors","volume":"52","author":"C Vandeputte","year":"2011","journal-title":"J Nucl Med"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11307-013-0626-y","article-title":"Whole-body biodistribution and radiation dosimetry of the cannabinoid type 2 receptor ligand [11C]-NE40 in healthy subjects","volume":"15","author":"R Ahmad","year":"2013","journal-title":"Mol Imaging Biol"},{"issue":"Suppl 2","key":"ref18","first-page":"188","article-title":"Quantification of 11C-NE40, a novel PET radioligand for CB2 receptor imaging","volume":"54","author":"A Postnov","year":"2013","journal-title":"J Nucl Med"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Hortala L, Arnaud J, Roux P, Oustric D, Oury-Donat F, Avenet P, et al. Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor. Bioorg Med Chem Lett. 2013. doi: 10.1016\/j.bmcl.2013.11.023<\/ext-link><\/comment> 24291040<\/object-id>.","DOI":"10.1016\/j.bmcl.2013.11.023"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/jpet.108.145011","article-title":"Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging","volume":"328","author":"BB Yao","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"issue":"14","key":"ref21","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1016\/j.bmc.2010.05.058","article-title":"Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)","volume":"18","author":"AG Horti","year":"2010","journal-title":"Bioorg Med Chem"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"L Qin","year":"2007","journal-title":"Glia"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"JL Jankowsky","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: a comparison of strategies","volume":"17","author":"JL Jankowsky","year":"2001","journal-title":"Biomol Eng"},{"issue":"1\u20132","key":"ref25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2006.08.002","article-title":"Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages","volume":"181","author":"S Mukhopadhyay","year":"2006","journal-title":"J Neuroimmunol"},{"issue":"35","key":"ref26","doi-asserted-by":"crossref","first-page":"11136","DOI":"10.1523\/JNEUROSCI.23-35-11136.2003","article-title":"Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains","volume":"23","author":"C Benito","year":"2003","journal-title":"J Neurosci"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","article-title":"High-level neuronal expression of abeta 1\u201342 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation","volume":"20","author":"L Mucke","year":"2000","journal-title":"J Neurosci"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.96.6.3228","article-title":"Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models","volume":"96","author":"AY Hsia","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","article-title":"Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins","volume":"19","author":"DR Borchelt","year":"1997","journal-title":"Neuron"},{"issue":"51","key":"ref30","doi-asserted-by":"crossref","first-page":"13805","DOI":"10.1523\/JNEUROSCI.4218-08.2008","article-title":"Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease","volume":"28","author":"Y Liu","year":"2008","journal-title":"J Neurosci"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.nbd.2004.10.022","article-title":"Episodic-like memory deficits in the APPswe\/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities","volume":"18","author":"A Savonenko","year":"2005","journal-title":"Neurobiology of disease"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuron.2011.01.002","article-title":"Anti-abeta therapeutics in Alzheimer's disease: the need for a paradigm shift","volume":"69","author":"TE Golde","year":"2011","journal-title":"Neuron"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuropharm.2013.11.015","article-title":"Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage","volume":"79","author":"D Durand","year":"2014","journal-title":"Neuropharmacology"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.neuroscience.2006.05.001","article-title":"Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern","volume":"141","author":"T Melnikova","year":"2006","journal-title":"Neuroscience"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1750-1326-6-45","article-title":"Microglial phagocytosis induced by fibrillar beta-amyloid is attenuated by oligomeric beta-amyloid: implications for Alzheimer's disease","volume":"6","author":"XD Pan","year":"2011","journal-title":"Mol Neurodegener"},{"issue":"25","key":"ref36","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1073\/pnas.0701096104","article-title":"Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors","volume":"104","author":"N Zelcer","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/01.jnen.0000178444.33972.e0","article-title":"Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics","volume":"64","author":"D Morgan","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2\u20133","key":"ref38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(00)00211-9","article-title":"Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor","volume":"396","author":"NE Buckley","year":"2000","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1523\/JNEUROSCI.4251-12.2013","article-title":"Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis","volume":"33","author":"T Melnikova","year":"2013","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1196\/annals.1432.036","article-title":"Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression","volume":"1139","author":"ES Onaivi","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"5746","key":"ref41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.1115740","article-title":"Identification and functional characterization of brainstem cannabinoid CB2 receptors","volume":"310","author":"MD Van Sickle","year":"2005","journal-title":"Science"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00210-013-0930-8","article-title":"Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina","volume":"387","author":"B Cecyre","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1369\/0022155414530995","article-title":"Validating Antibodies to the Cannabinoid CB2 Receptor: Antibody Sensitivity Is Not Evidence of Antibody Specificity","volume":"62","author":"Y Marchalant","year":"2014","journal-title":"J Histochem Cytochem"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Dowie MJ, Grimsey NL, Hoffman T, Faull RL, Glass M. Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain. J Chem Neuroanat. 2014. doi: 10.1016\/j.jchemneu.2014.06.004<\/ext-link><\/comment> 24978314<\/object-id>.","DOI":"10.1016\/j.jchemneu.2014.06.004"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"11","key":"ref46","first-page":"1891","article-title":"Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner","volume":"47","author":"Y Wang","year":"2006","journal-title":"J Nucl Med"},{"issue":"6441","key":"ref47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"S Munro","year":"1993","journal-title":"Nature"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.neuroscience.2005.07.014","article-title":"A three-dimensional digital atlas database of the adult C57BL\/6J mouse brain by magnetic resonance microscopy","volume":"135","author":"Y Ma","year":"2005","journal-title":"Neuroscience"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroimage.2007.06.032","article-title":"A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator","volume":"38","author":"MM Mirrione","year":"2007","journal-title":"Neuroimage"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.11.035","article-title":"Cannabinoid CB2 receptors: immunohistochemical localization in rat brain","volume":"1071","author":"JP Gong","year":"2006","journal-title":"Brain Res"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1476-5381.2010.00729.x","article-title":"CB2: a cannabinoid receptor with an identity crisis","volume":"160","author":"BK Atwood","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"46","key":"ref52","doi-asserted-by":"crossref","first-page":"E5007","DOI":"10.1073\/pnas.1413210111","article-title":"Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice","volume":"111","author":"HY Zhang","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1073\/pnas.1118167109","article-title":"Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors","volume":"109","author":"FS den Boon","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0022-3565(25)38654-4","article-title":"Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids","volume":"268","author":"AB Lynn","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","article-title":"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations","volume":"232","author":"S Galiegue","year":"1995","journal-title":"Eur J Biochem"},{"issue":"1\u20132","key":"ref56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0009-3084(00)00195-X","article-title":"Cannabinoid receptors and the regulation of immune response","volume":"108","author":"EV Berdyshev","year":"2000","journal-title":"Chem Phys Lipids"},{"issue":"1\u20132","key":"ref57","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0009-3084(00)00189-4","article-title":"2-Arachidonoylglycerol and the cannabinoid receptors","volume":"108","author":"T Sugiura","year":"2000","journal-title":"Chem Phys Lipids"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroscience.2007.10.029","article-title":"Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome","volume":"151","author":"E Nunez","year":"2008","journal-title":"Neuroscience"},{"issue":"2\u20133","key":"ref59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-5728(90)90061-Q","article-title":"New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury","volume":"27","author":"MB Graeber","year":"1990","journal-title":"J Neuroimmunol"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hep.1840200208","article-title":"Immunohistochemical phenotyping of liver macrophages in normal and diseased human liver","volume":"20","author":"M Tomita","year":"1994","journal-title":"Hepatology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fncel.2013.00006","article-title":"Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis","volume":"7","author":"A Sierra","year":"2013","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1124\/jpet.107.121566","article-title":"Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence","volume":"322","author":"G Esposito","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/glia.20108","article-title":"Synthetic cannabinoid WIN55,212\u20132 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes","volume":"49","author":"WS Sheng","year":"2005","journal-title":"Glia"},{"issue":"3","key":"ref64","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/sj.bjp.0702351","article-title":"Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630","volume":"126","author":"RA Ross","year":"1999","journal-title":"Br J Pharmacol"},{"issue":"21","key":"ref65","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease","volume":"25","author":"JL Jankowsky","year":"2005","journal-title":"J Neurosci"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/jnr.22266","article-title":"DHA diet reduces AD pathology in young APPswe\/PS1 Delta E9 transgenic mice: possible gender effects","volume":"88","author":"SE Perez","year":"2010","journal-title":"J Neurosci Res"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1172\/JCI66407","article-title":"Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis","volume":"124","author":"D Sepulveda-Falla","year":"2014","journal-title":"J Clin Invest"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2012-120907","article-title":"Phenotypic profile of early-onset familial Alzheimer's disease caused by presenilin-1 E280A mutation","volume":"32","author":"D Sepulveda-Falla","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/sj.bjp.0707584","article-title":"CB2 receptors in the brain: role in central immune function","volume":"153","author":"GA Cabral","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"5","key":"ref70","first-page":"373","article-title":"Cannabinoids for the treatment of inflammation","volume":"8","author":"JC Ashton","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2009.05.098","article-title":"The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages","volume":"1283","author":"RM Tolon","year":"2009","journal-title":"Brain Res"},{"issue":"4","key":"ref72","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions","volume":"11","author":"GW Rebeck","year":"1993","journal-title":"Neuron"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0197-4580(94)00064-6","article-title":"Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: colocalization with amyloid plaques","volume":"15","author":"EJ Mufson","year":"1994","journal-title":"Neurobiology of aging"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/nbdi.1996.0003","article-title":"Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation","volume":"3","author":"CA Lemere","year":"1996","journal-title":"Neurobiol Dis"},{"issue":"7344","key":"ref75","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10071","article-title":"Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'","volume":"472","author":"HS Goodridge","year":"2011","journal-title":"Nature"},{"issue":"7","key":"ref76","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nri3244","article-title":"Information processing during phagocytosis","volume":"12","author":"DM Underhill","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1742-2094-2-29","article-title":"Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation","volume":"2","author":"J Ehrhart","year":"2005","journal-title":"J Neuroinflammation"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3233\/JAD-130137","article-title":"CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AbetaPP\/PS1 mice","volume":"35","author":"E Aso","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-9-8","article-title":"Prolonged oral cannabinoid administration prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in Tg APP 2576 mice","volume":"9","author":"AM Martin-Moreno","year":"2012","journal-title":"J Neuroinflammation"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2119\/molmed.2013.00140","article-title":"CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer's Disease","volume":"19","author":"J Koppel","year":"2013","journal-title":"Mol Med"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.neurobiolaging.2014.09.019","article-title":"Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model","volume":"36","author":"AC Schmole","year":"2015","journal-title":"Neurobiology of aging"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T18:43:55Z","timestamp":1748457835000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129618"}},"subtitle":[],"editor":[{"given":"Joseph","family":"El Khoury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":81,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129618","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]}}}