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Lindauer","year":"2004","journal-title":"BiolPsychiatry"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1176\/appi.ajp.160.5.924","article-title":"MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder","volume":"160","author":"JD Bremner","year":"2003","journal-title":"Am J Psychiatry"},{"key":"ref17","unstructured":"Defense and Veterans Brain Injury Center. DoD Worldwide Numbers for TBI 2014 [cited 2014 September 9]. Available: http:\/\/dvbic.dcoe.mil\/dod-worldwide-numbers-tbi<\/ext-link>."},{"key":"ref18","unstructured":"Fischer H. U.S. Military Casualty Statistics: Operation New Dawn, Operation Iraqi Freedom, and Operation Enduring Freedom 2014 Nov. 20, 2014. Congressional Research Service."},{"key":"ref19","unstructured":"National Institute of Mental Health. Post-Traumatic Stress Disorder (PTSD) [cited 2014 September 9]. Available from: http:\/\/www.nimh.nih.gov\/health\/topics\/post-traumatic-stress-disorder-ptsd\/index.shtml<\/ext-link>."},{"key":"ref20","unstructured":"Centers for Disease Control and Prevention. Injury Prevention and Control: Traumatic Brain Injury [cited 2014 September 9]. Available: http:\/\/www.cdc.gov\/TraumaticBrainInjury\/<\/ext-link>"},{"issue":"2","key":"ref21","first-page":"211","article-title":"Viewing the functional consequences of traumatic brain injury by using brain SPECT","volume":"60","author":"D Pavel","year":"2006","journal-title":"Brain and Cogn"},{"issue":"2","key":"ref22","first-page":"447","article-title":"Technetium Tc-99m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study","volume":"27","author":"NK Gowda","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00006231-200404000-00004","article-title":"Role of brain perfusion single-photon emission tomography in traumatic head injury","volume":"25","author":"K Kinuya","year":"2004","journal-title":"Nucl Med Commun"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.61.2.168","article-title":"Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD","volume":"61","author":"LM Shin","year":"2004","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0006-3223(03)00525-0","article-title":"Resting regional cerebral perfusion in recent posttraumatic stress disorder","volume":"54","author":"O Bonne","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/da.20208","article-title":"Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings","volume":"24","author":"V Francati","year":"2007","journal-title":"Depress and Anxiety"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.biopsych.2004.08.003","article-title":"Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder","volume":"56","author":"RJ Lindauer","year":"2004","journal-title":"Biol Psychiatry"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/milmed\/165.6.473","article-title":"Increased regional cerebral perfusion by 99mTc hexamethyl propylene amine oxime single photon emission computed tomography in post-traumatic stress disorder","volume":"165","author":"N Sachinvala","year":"2000","journal-title":"Mil Med"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0327(03)00047-8","article-title":"Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor","volume":"80","author":"S Seedat","year":"2004","journal-title":"J Affect Disord"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-3956(98)00060-0","article-title":"Medial frontal cortex involvement in PTSD symptoms: a SPECT study","volume":"33","author":"JK Zubieta","year":"1999","journal-title":"J Psychiatr Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1192\/bjp.171.4.346","article-title":"Brain blood flow in anxiety disorders. 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Web-based Injury Statistics Query and Reporting System (WISQUARS). Available at http:\/\/www.cdc.gov\/injury\/wisqars\/LeadingCauses.html<\/ext-link>. Assessed via National Vital Statistics System- 2007."},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1089\/neu.2012.2399","article-title":"Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability","volume":"30","author":"ML Prins","year":"2013","journal-title":"J Neurotrauma"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.csm.2010.09.001","article-title":"The molecular pathophysiology of concussive brain injury","volume":"30","author":"G Barkhoudarian","year":"2011","journal-title":"Clin Sports Med"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/jcbfm.2009.203","article-title":"Traumatic brain injury: an overview of pathobiology with emphasis on military populations","volume":"30","author":"I Cernak","year":"2010","journal-title":"J Cereb Blood Flow 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Psychiatry"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archpsyc.61.1.42","article-title":"Major depression following traumatic brain injury","volume":"61","author":"RE Jorge","year":"2004","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.apmr.2007.12.029","article-title":"Neuropsychologic and functional outcome after complicated mild traumatic brain injury","volume":"89","author":"S Kashluba","year":"2008","journal-title":"Arch Phys Med Rehabil"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1176\/ajp.152.10.1493","article-title":"Psychiatric disorders and functional disability in outpatients with traumatic brain injuries","volume":"152","author":"JR Fann","year":"1995","journal-title":"Am J Psychiatry"},{"issue":"19","key":"ref50","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1001\/jama.2010.599","article-title":"Rates of major depressive disorder and clinical outcomes following traumatic brain injury","volume":"303","author":"CH Bombardier","year":"2010","journal-title":"JAMA"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1177\/0363546512456193","article-title":"Nine-year risk of depression diagnosis increases with increasing self-reported concussions in retired professional football players","volume":"40","author":"ZY Kerr","year":"2012","journal-title":"Am J Sports Med"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1176\/jnp.2006.18.4.501","article-title":"Posttraumatic stress disorder symptoms during the first six months after traumatic brain injury","volume":"18","author":"CH Bombardier","year":"2006","journal-title":"Neuropsychiatry Clin 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(PTSD)","volume":"8","author":"G Sartory","year":"2013","journal-title":"PloS One"},{"issue":"Suppl 1","key":"ref76","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.neuroimage.2010.04.008","article-title":"Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms","volume":"54","author":"ER Peskind","year":"2011","journal-title":"NeuroImage"},{"issue":"6","key":"ref77","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/070674371405900602","article-title":"Resting-state neuroimaging studies: a new way of identifying differences and similarities among the anxiety disorders?","volume":"59","author":"A Peterson","year":"2014","journal-title":"Can J Psychiatry"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0447.2009.01391.x","article-title":"Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects","volume":"121","author":"RA Lanius","year":"2010","journal-title":"Acta Psychiatr Scand"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"RL Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"ref80","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pscychresns.2011.08.007","article-title":"Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault","volume":"201","author":"SY Kim","year":"2012","journal-title":"Psychiatry Res"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.clinph.2005.10.020","article-title":"Alterations in cerebral perfusion in posttraumatic stress disorder patients 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Krystal","year":"2014","journal-title":"Cell"},{"issue":"7872","key":"ref85","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness. A practical scale","volume":"2","author":"G Teasdale","year":"1974","journal-title":"Lancet"},{"key":"ref86","unstructured":"DOD\/VA COMMON DEFINITION OF TBI 2008. Available: http:\/\/www.cdc.gov\/nchs\/data\/icd\/Sep08TBI.pdf<\/ext-link>."},{"issue":"2","key":"ref87","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/02791072.2008.10400622","article-title":"Predicting positive and negative treatment responses to stimulants with brain SPECT imaging","volume":"40","author":"DG Amen","year":"2008","journal-title":"J Psychoactive Drugs"},{"issue":"2","key":"ref88","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/02791072.2008.10400623","article-title":"Preliminary evidence differentiating ADHD using brain SPECT imaging in older patients","volume":"40","author":"DG Amen","year":"2008","journal-title":"J Psychoactive Drugs"},{"issue":"7","key":"ref89","first-page":"788","article-title":"The sources of overestimation in the quantification by SPECT of uptakes in a myocardial phantom: concise communication","volume":"25","author":"W Chang","year":"1984","journal-title":"J Nucl Med"},{"issue":"1","key":"ref90","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"ref91","first-page":"852","article-title":"A note on the estimation of the location parameters of the Cauchy distribution","volume":"61","author":"JT Thomas","year":"1964","journal-title":"J Am Stat Assoc"},{"key":"ref92","article-title":"Atlas of the Human Brain","author":"JK Mai","year":"1997"},{"key":"ref93","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21606-5","article-title":"The elements of statistical learning: Data mining, inference, and prediction","author":"TT Hastie","year":"2001"},{"issue":"3","key":"ref94","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/archpsyc.1997.01830150070011","article-title":"Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder","volume":"54","author":"JD Bremner","year":"1997","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"ref95","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S0033291707001432","article-title":"Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial","volume":"38","author":"RJ Lindauer","year":"2008","journal-title":"Psychol Med"},{"issue":"2","key":"ref96","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1076\/1385-4046(200005)14:2;1-Z;FT223","article-title":"Comparison of time and error rates on the trail making test among patients with head injuries, experimental malingerers, patients with suspect effort on testing, and normal controls","volume":"14","author":"LF Ruffolo","year":"2000","journal-title":"Clin Neuropsychol"},{"issue":"18","key":"ref97","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1001\/jama.298.18.2141","article-title":"Longitudinal assessment of mental health problems among active and reserve component soldiers returning from the Iraq war","volume":"298","author":"CS Milliken","year":"2007","journal-title":"JAMA"},{"issue":"7640","key":"ref98","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/bmj.39430.638241.AE","article-title":"New onset and persistent symptoms of post-traumatic stress disorder self reported after deployment and combat exposures: prospective population based US military cohort study","volume":"336","author":"TC Smith","year":"2008","journal-title":"BMJ"},{"issue":"6","key":"ref99","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1682\/JRRD.2009.01.0008","article-title":"Veterans with history of mild traumatic brain injury and posttraumatic stress disorder: challenges from provider perspective","volume":"46","author":"NA Sayer","year":"2009","journal-title":"J Rehabil Res Dev"},{"issue":"8","key":"ref100","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1682\/JRRD.2011.07.0131","article-title":"Postdeployment symptom changes and traumatic brain injury and\/or posttraumatic stress disorder in men","volume":"49","author":"CA Macera","year":"2012","journal-title":"J Rehabil Res Dev"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1176\/appi.ps.201100199","article-title":"Concordance between psychotropic prescribing for veterans with PTSD and clinical practice guidelines","volume":"63","author":"S Jain","year":"2012","journal-title":"Psychiatr Serv"},{"issue":"6","key":"ref102","doi-asserted-by":"crossref","first-page":"e541","DOI":"10.4088\/JCP.12r08225","article-title":"Meta-analysis of the efficacy of treatments for posttraumatic stress disorder","volume":"74","author":"BV Watts","year":"2013","journal-title":"J Clin Psychiatry"},{"issue":"2","key":"ref103","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1176\/appi.ps.201000531","article-title":"Pharmacotherapy regimens among patients with posttraumatic stress disorder and mild traumatic brain injury","volume":"63","author":"M Morgan","year":"2012","journal-title":"Psychiatr Serv"},{"key":"ref104","first-page":"609","article-title":"Textbook of Traumatic Brain Injury","author":"JM Silver","year":"2011"},{"issue":"3","key":"ref105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S2045796013000449","article-title":"The use of second generation antipsychotics for post-traumatic stress disorder in a US Veterans Health Administration Medical Center","volume":"23","author":"E Hermes","year":"2014","journal-title":"Epidemiol Psychiatr Sci"},{"issue":"5","key":"ref106","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/jama.2011.1080","article-title":"Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial","volume":"306","author":"JH Krystal","year":"2011","journal-title":"JAMA"},{"issue":"6","key":"ref107","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/WNF.0b013e3182aa365f","article-title":"Atypical antipsychotics in the treatment of posttraumatic stress disorder","volume":"36","author":"HR Wang","year":"2013","journal-title":"Clin Neuropharmacol"},{"issue":"3","key":"ref108","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neulet.2008.10.076","article-title":"Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury","volume":"448","author":"AE Kline","year":"2008","journal-title":"Neurosci Lett"},{"issue":"8","key":"ref109","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1089\/neu.2014.3711","article-title":"Divergent long-term consequences of chronic treatment with haloperidol, risperidone, and bromocriptine on traumatic brain injury-induced cognitive deficits","volume":"32","author":"TI Phelps","year":"2015","journal-title":"J Neurotrauma"},{"issue":"9","key":"ref110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/070674371405900905","article-title":"Repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex for treating posttraumatic stress disorder: an exploratory meta-analysis of randomized, double-blind and sham-controlled trials","volume":"59","author":"MT Berlim","year":"2014","journal-title":"Can J Psychiatry"},{"issue":"2","key":"ref111","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.annfar.2013.11.006","article-title":"Transcranial magnetic stimulation in brain injury","volume":"33","author":"E Castel-Lacanal","year":"2014","journal-title":"Ann Fr Anesth Reanim"},{"issue":"6","key":"ref112","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/1941738110383963","article-title":"Twelve years of national football league concussion data","volume":"2","author":"IR Casson","year":"2010","journal-title":"Sports Health"},{"issue":"1","key":"ref113","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1941738110391413","article-title":"Repeat concussions in the national football league","volume":"3","author":"IR Casson","year":"2011","journal-title":"Sports Health"},{"issue":"12","key":"ref114","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.annepidem.2013.07.022","article-title":"Incidence of sport-related traumatic brain injury 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