{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:49:29Z","timestamp":1792684169270,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0129725","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T17:33:22Z","timestamp":1434130402000},"page":"e0129725","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cellular Changes during Renal Failure-Induced Inflammatory Aortic Valve Disease"],"prefix":"10.1371","volume":"10","author":[{"given":"Mony","family":"Shuvy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Abedat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitsan","family":"Duvdevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Meir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Beeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim","family":"Lotan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/CIRCULATIONAHA.106.657759","article-title":"Calcific aortic stenosis: a disease ready for prime time","volume":"114","author":"NM Rajamannan","year":"2006","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","article-title":"Human aortic valve calcification is associated with an osteoblast phenotype","volume":"107","author":"NM Rajamannan","year":"2003","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1161\/01.ATV.0000228824.01604.63","article-title":"Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves","volume":"26","author":"S Helske","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/eurheartj\/ehq237","article-title":"Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation","volume":"31","author":"J Hjortnaes","year":"2010","journal-title":"Eur Heart J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.echo.2006.01.026","article-title":"Rate of Progression of Valvular Aortic Stenosis in Patients Undergoing Dialysis","volume":"19","author":"T Kume","year":"2006","journal-title":"J Am Soc Echocardiogr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/cvr\/cvn088","article-title":"Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats","volume":"79","author":"M Shuvy","year":"2008","journal-title":"Cardiovasc Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"H1829","DOI":"10.1152\/ajpheart.00240.2010","article-title":"Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure","volume":"300","author":"M Shuvy","year":"2011","journal-title":"Am J Physiol Heart Circ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.etp.2010.02.002","article-title":"Histopathology and apoptosis in an animal model of reversible renal injury","volume":"63","author":"M Shuvy","year":"2011","journal-title":"Exp Toxicol Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1161\/01.CIR.0000017435.87463.72","article-title":"Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve","volume":"105","author":"NM Rajamannan","year":"2002","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/hrt.2003.029785","article-title":"Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve","volume":"91","author":"NM Rajamannan","year":"2005","journal-title":"Heart"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJMoa0804602","article-title":"Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis","volume":"359","author":"AB Rosseb\u00f8","year":"2008","journal-title":"N Engl J. Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/CIRCULATIONAHA.109.900027","article-title":"Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis: Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial","volume":"121","author":"KL Chan","year":"2010","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0735-1097(01)01422-X","article-title":"Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study","volume":"38","author":"Y Agmon","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"18C","DOI":"10.1016\/S0002-9149(99)80466-4","article-title":"Pathogenesis of atherosclerosis","volume":"76","author":"M Navab","year":"1995","journal-title":"Am J Cardiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/ATVBAHA.107.156752","article-title":"Calcific aortic stenosis: lessons learned from experimental and clinical studies","volume":"29","author":"NM Rajamannan","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","article-title":"Human aortic valve calcification is associated with an osteoblast phenotype","volume":"107","author":"NM Rajamannan","year":"2003","journal-title":"Circulation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","article-title":"Bone formation and inflammation in cardiac valves","volume":"103","author":"ER Mohler 3rd","year":"2001","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2008.09.052","article-title":"Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2","volume":"53","author":"X Yang","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1161\/CIRCULATIONAHA.104.473165","article-title":"Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation","volume":"111","author":"NM Rajamannan","year":"2005","journal-title":"Circulation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/10454411920030030501","article-title":"Concepts of Osteoblast Growth and Differentiation: Basis for Modulation of Bone Cell Development and Tissue Formation","volume":"3","author":"JB Lian","year":"1992","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/CIRCRESAHA.110.234237","article-title":"Cell\u2013Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease: Critical Roles for Matricellular, Matricrine, and Matrix Mechanics Cues","volume":"108","author":"J-H Chen","year":"2011","journal-title":"Circ Res"},{"key":"ref22","first-page":"218","article-title":"Localization and pattern of expression of extracellular matrix components in human heart valves","volume":"14","author":"N Latif","year":"2005","journal-title":"J Heart Valve Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.90.2.844","article-title":"Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies","volume":"90","author":"CM Otto","year":"1994","journal-title":"Circulation"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/eurheartj\/ehi248","article-title":"Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors","volume":"26","author":"O Fondard","year":"2005","journal-title":"Eur Heart J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0003-4975(03)00529-0","article-title":"Evidence for an altered balance between matrix metalloproteinase-9 and its inhibitors in calcific aortic stenosis","volume":"76","author":"J Satta","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/hc4601.099489","article-title":"Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves","volume":"104","author":"E Rabkin","year":"2001","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.ph.53.030191.001113","article-title":"Control of Growth and Differentiation of Vascular Cells by Extracellular Matrix Proteins","volume":"53","author":"DJ Carey","year":"1991","journal-title":"Annu Rev Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.2000.tb06299.x","article-title":"The Extracellular Matrix Dynamically Regulates Smooth Muscle Cell Responsiveness to PDGFa","volume":"902","author":"EW Raines","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/01.ATV.18.12.1964","article-title":"Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory","volume":"18","author":"KE Watson","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/386078a0","article-title":"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein","volume":"386","author":"G Luo","year":"1997","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0129725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T17:11:38Z","timestamp":1566839498000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0129725"}},"subtitle":[],"editor":[{"given":"Elena","family":"Aikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0129725","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]}}}