{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:38:11Z","timestamp":1775165891697,"version":"3.50.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0130175","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T21:54:00Z","timestamp":1434146040000},"page":"e0130175","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Microcystic Inner Nuclear Layer Changes and Retinal Nerve Fiber Layer Defects in Eyes with Glaucoma"],"prefix":"10.1371","volume":"10","author":[{"given":"Tomoko","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadamichi","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munemitsu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Suda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Unoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanako Ohashi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagahisa","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.ophtha.2009.05.025","article-title":"Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography","volume":"116","author":"O Tan","year":"2009","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0002-9394(89)90488-1","article-title":"Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma","volume":"107","author":"HA Quigley","year":"1989","journal-title":"Am J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.ophtha.2011.06.015","article-title":"Macular ganglion cell layer imaging in preperimetric glaucoma with speckle noise-reduced spectral domain optical coherence tomography","volume":"118","author":"N Nakano","year":"2011","journal-title":"Ophthalmology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ajo.2013.06.029","article-title":"Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma","volume":"156","author":"Y Kimura","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1167\/iovs.10-5572","article-title":"Three-dimensional imaging of macular inner structures in glaucoma by using spectral-domain optical coherence tomography","volume":"52","author":"Y Kotera","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1167\/iovs.11-7962","article-title":"Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma","volume":"52","author":"JC Mwanza","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1167\/iovs.12-10210","article-title":"A novel method to detect local ganglion cell loss in early glaucoma using spectral-domain optical coherence tomography","volume":"53","author":"K Takayama","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.ophtha.2010.01.026","article-title":"Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection","volume":"117","author":"CK Leung","year":"2010","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.ophtha.2012.03.044","article-title":"Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: patterns of retinal nerve fiber layer progression","volume":"119","author":"CK Leung","year":"2012","journal-title":"Ophthalmology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ajo.2013.04.028","article-title":"Macular imaging in highly myopic eyes with and without glaucoma","volume":"156","author":"N Nakano","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/bjo.2010.183756","article-title":"Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging","volume":"95","author":"SS Choi","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1167\/iovs.07-0980","article-title":"Changes in cellular structures revealed by ultra-high resolution retinal imaging in optic neuropathies","volume":"49","author":"SS Choi","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","first-page":"264803","article-title":"Measurement of photoreceptor layer in glaucoma: a spectral-domain optical coherence tomography study","volume":"2011","author":"N Fan","year":"2011","journal-title":"J Ophthalmol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1167\/iovs.10-5551","article-title":"Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT","volume":"51","author":"L Guo","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/archopht.118.2.235","article-title":"Swelling and Loss of Photoreceptorsin Chronic Human and Experimental Glaucomas","volume":"118","author":"TM Nork","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/eye.2010.218","article-title":"Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathies","volume":"25","author":"JS Werner","year":"2011","journal-title":"Eye (Lond)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00153011","article-title":"The electroretinogram in advanced open-angle glaucoma","volume":"63","author":"DT Fazio","year":"1986","journal-title":"Doc Ophthalmol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/brain\/aws098","article-title":"Microcystic macular oedema in multiple sclerosis is associated with disease severity","volume":"135","author":"JM Gelfand","year":"2012","journal-title":"Brain"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1097\/IAE.0b013e31828e68d0","article-title":"Retinal inner nuclear layer microcystic changes in optic nerve atrophy: a novel spectral-domain OCT finding","volume":"33","author":"B Wolff","year":"2013","journal-title":"Retina"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e78341","DOI":"10.1371\/journal.pone.0078341","article-title":"Inner nuclear layer thickening is inversley proportional to retinal ganglion cell loss in optic neuritis","volume":"8","author":"M Kaushik","year":"2013","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1093\/brain\/aws216","article-title":"Microcystic macular oedema confirmed, but not specific for multiple sclerosis","volume":"135","author":"LJ Balk","year":"2012","journal-title":"Brain"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/jamaneurol.2013.1832","article-title":"Microcystic inner nuclear layer abnormalities and neuromyelitis optica","volume":"70","author":"JM Gelfand","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e71145","DOI":"10.1371\/journal.pone.0071145","article-title":"Optic neuritis is associated with inner nuclear layer thickening and microcystic macular edema independently of multiple sclerosis","volume":"8","author":"F Kaufhold","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1212\/WNL.0b013e31828c2f7a","article-title":"In vivo identification of morphologic retinal abnormalities in neuromyelitis optica","volume":"80","author":"ES Sotirchos","year":"2013","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1093\/brain\/aws215","article-title":"Microcystic macular degeneration from optic neuropathy","volume":"135","author":"M Abegg","year":"2012","journal-title":"Brain"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1093\/brain\/awt014","article-title":"Microcystic macular degeneration from optic neuropathy: not inflammatory, not trans-synaptic degeneration","volume":"136","author":"P Barboni","year":"2013","journal-title":"Brain"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S1474-4422(12)70213-2","article-title":"Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study","volume":"11","author":"S Saidha","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1001\/archopht.1985.01050120030015","article-title":"Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1","volume":"103","year":"1985","journal-title":"Arch Ophthalmol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/A:1002192829817","article-title":"Mechanisms of fluid accumulation in retinal edema","volume":"97","author":"MF Marmor","year":"1999","journal-title":"Doc Ophthalmol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ajo.2011.05.028","article-title":"Identifying a clinically meaningful threshold for change in uveitic macular edema evaluated by optical coherence tomography","volume":"152","author":"EA Sugar","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"ref31","first-page":"537","article-title":"Perifoveal vitreous detachment and its macular complications","volume":"103","author":"MW Johnson","year":"2005","journal-title":"Trans Am Ophthalmol Soc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00006982-200504000-00007","article-title":"Removal of adherent cortical vitreous plaques without removing the internal limiting membrane in the repair of macular detachments in highly myopic eyes","volume":"25","author":"RF Spaide","year":"2005","journal-title":"Retina"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ajo.2011.06.016","article-title":"The diversity of traction mechanisms in myopic traction maculopathy","volume":"153","author":"BL VanderBeek","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ophtha.2013.08.045","article-title":"Microcystic macular edema: retrograde maculopathy caused by optic neuropathy","volume":"121","author":"M Abegg","year":"2014","journal-title":"Ophthalmology"},{"key":"ref35","article-title":"Clinical decisions in glaucoma","author":"E PR Hodapp","year":"1993"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e34823","DOI":"10.1371\/journal.pone.0034823","article-title":"The OSCAR-IB consensus criteria for retinal OCT quality assessment","volume":"7","author":"P Tewarie","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.ajo.2014.08.040","article-title":"Asymmetry Analysis of Macular Inner Retinal Layers for Glaucoma Diagnosis","volume":"158","author":"H Yamada","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1001\/jamaophthalmol.2013.4578","article-title":"Evolution of vitreomacular detachment in healthy subjects","volume":"131","author":"H Itakura","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1167\/iovs.09-5067","article-title":"Spatial pattern of glaucomatous visual field loss obtained with regionally condensed stimulus arrangements","volume":"51","author":"U Schiefer","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e260","DOI":"10.1093\/brain\/awt154","article-title":"Microcysts in the inner nuclear layer from optic atrophy are caused by retrograde trans-synaptic degeneration combined with vitreous traction on the retinal surface","volume":"136","author":"BJ Lujan","year":"2013","journal-title":"Brain"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1167\/iovs.11-7716","article-title":"Hypodense regions (holes) in the retinal nerve fiber layer in frequency-domain OCT scans of glaucoma patients and suspects","volume":"52","author":"D Xin","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1212\/WNL.0000000000000545","article-title":"Dynamic formation of macular microcysts independent of vitreous traction changes","volume":"83","author":"AU Brandt","year":"2014","journal-title":"Neurology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1093\/brain\/awt155","article-title":"Reply: Microcysts in the inner nuclear layer from optic atrophy are caused by retrograde trans-synaptic degeneration combined with vitreous traction on the retinal surface","volume":"136","author":"AJ Green","year":"2013","journal-title":"Brain"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00417-012-2253-8","article-title":"Delayed onset inner nuclear layer cystic changes following internal limiting membrane removal for epimacular membrane","volume":"251","author":"EJ Sigler","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jnnp-2014-308189","article-title":"Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis","volume":"86","author":"LJ Balk","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1136\/jnnp.26.5.402","article-title":"Trans-synaptic retrograde degeneration in the visual system of primates","volume":"26","author":"JM Vanburen","year":"1963","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/brain\/awq080","article-title":"Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration","volume":"133","author":"AJ Green","year":"2010","journal-title":"Brain"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11910-008-0066-2","article-title":"Neuromyelitis optica: diagnosis, pathogenesis, and treatment","volume":"8","author":"B Cree","year":"2008","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jneuroim.2007.04.009","article-title":"Neuromyelitis optica: changing concepts","volume":"187","author":"A Jacob","year":"2007","journal-title":"J Neuroimmunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/jnnp.2008.166207","article-title":"Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica following optic neuritis","volume":"80","author":"AJ Green","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0130175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:45:06Z","timestamp":1540309506000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0130175"}},"subtitle":[],"editor":[{"given":"Friedemann","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,12]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0130175","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,12]]}}}