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Brodmann&apos;s Interactive Atlas Miami: Miami Children&apos;s Hospital, Department of Radiology \/ Brain Institute; 2008 [cited 2008]. An interactive atlas which displays functional properties of areas you can select]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fmriconsulting.com\/brodmann\/index.html\" xlink:type=\"simple\">http:\/\/www.fmriconsulting.com\/brodmann\/index.html<\/ext-link>."},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00415-014-7545-y","article-title":"Frontostriatal dysexecutive syndrome: a core cognitive feature of myotonic dystrophy type 2","volume":"262","author":"S Peric","year":"2015","journal-title":"Journal of neurology"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11065-010-9142-x","article-title":"The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy","volume":"20","author":"JD Schmahmann","year":"2010","journal-title":"Neuropsychology review"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)00912-6","article-title":"The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer&apos;s disease","volume":"172","author":"KA Michelsen","year":"2008","journal-title":"Progress in brain research"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1468-1331.2011.03352.x","article-title":"Sleep disorders in adult-onset myotonic dystrophy type 1: a controlled polysomnographic study","volume":"18","author":"A Romigi","year":"2011","journal-title":"European journal of neurology: the official journal of the European Federation of Neurological Societies"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.sleep.2007.03.006","article-title":"Neuroimaging in sleep medicine","volume":"8","author":"TT Dang-Vu","year":"2007","journal-title":"Sleep medicine"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1523\/JNEUROSCI.2030-12.2013","article-title":"Individual differences in white matter diffusion affect sleep oscillations","volume":"33","author":"G Piantoni","year":"2013","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.nmd.2014.01.013","article-title":"Consensus on cerebral involvement in myotonic dystrophy: workshop report: May 24\u201327, 2013, Ferrere (AT), Italy","volume":"24","author":"E Bugiardini","year":"2014","journal-title":"Neuromuscular disorders: NMD"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0130352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T15:13:31Z","timestamp":1566918811000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0130352"}},"subtitle":[],"editor":[{"given":"Ralf","family":"Krahe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0130352","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}