{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T07:31:47Z","timestamp":1775374307389,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0130401","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T14:36:22Z","timestamp":1434378982000},"page":"e0130401","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice"],"prefix":"10.1371","volume":"10","author":[{"given":"Franziska","family":"Bollmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"J\u00e4ckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Schmidtke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Schrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Jurk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huige","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Erkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Kleinert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pautz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.1.110304.100100","article-title":"Inflammation and atherosclerosis","volume":"1","author":"GK Hansson","year":"2006","journal-title":"Annu Rev Pathol"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"59","author":"JA Avina-Zubieta","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/art.20878","article-title":"Cardiovascular death in rheumatoid arthritis: a population-based study","volume":"52","author":"H Maradit-Kremers","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.7326\/0003-4819-144-4-200602210-00006","article-title":"Preclinical carotid atherosclerosis in patients with rheumatoid arthritis","volume":"144","author":"MJ Roman","year":"2006","journal-title":"Ann Intern Med"},{"issue":"17","key":"ref5","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.3748\/wjg.v20.i17.4857","article-title":"Venous thrombosis and prothrombotic factors in inflammatory bowel disease","volume":"20","author":"F Magro","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/1529-0131(200112)44:12<2737::AID-ART460>3.0.CO;2-#","article-title":"High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors","volume":"44","author":"ID del Rincon","year":"2001","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.021908.132620","article-title":"Immune and inflammatory mechanisms of atherosclerosis (*)","volume":"27","author":"E Galkina","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.immuni.2013.06.009","article-title":"Immune effector mechanisms implicated in atherosclerosis: from mice to humans","volume":"38","author":"P Libby","year":"2013","journal-title":"Immunity"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s10067-007-0803-y","article-title":"TNF-alpha blockade induces a reversible but transient effect on endothelial dysfunction in patients with long-standing severe rheumatoid arthritis","volume":"27","author":"S Bosello","year":"2008","journal-title":"Clin Rheumatol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/ard.2010.129916","article-title":"Tumour necrosis factor antagonist use and associated risk reduction of cardiovascular events among patients with rheumatoid arthritis","volume":"70","author":"JD Greenberg","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.trsl.2010.09.005","article-title":"Tumor necrosis factor-alpha blockade, cardiovascular outcomes, and survival in rheumatoid arthritis","volume":"157","author":"Z Al-Aly","year":"2011","journal-title":"Transl Res"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(00)02115-3","article-title":"Inhibition of interleukin-6 signaling by galiellalactone","volume":"484","author":"M Weidler","year":"2000","journal-title":"FEBS Lett"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxq451","article-title":"Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma","volume":"23","author":"M Hausding","year":"2011","journal-title":"Int Immunol"},{"issue":"23","key":"ref14","doi-asserted-by":"crossref","first-page":"15969","DOI":"10.1074\/jbc.M114.564252","article-title":"Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells","volume":"289","author":"N Don-Doncow","year":"2014","journal-title":"The Journal of biological chemistry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cbi.2014.02.012","article-title":"The fungal metabolite galiellalactone interferes with the nuclear import of NF-kappaB and inhibits HIV-1 replication","volume":"214","author":"M Perez","year":"2014","journal-title":"Chemico-biological interactions"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"P Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"issue":"15","key":"ref17","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/nar\/gki797","article-title":"Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR","volume":"33","author":"K Linker","year":"2005","journal-title":"Nucleic acids research"},{"issue":"20","key":"ref18","doi-asserted-by":"crossref","first-page":"12555","DOI":"10.1093\/nar\/gku1033","article-title":"Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity","volume":"42","author":"F Bollmann","year":"2014","journal-title":"Nucleic acids research"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1084\/jem.20012044","article-title":"A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation","volume":"196","author":"S Massberg","year":"2002","journal-title":"J Exp Med"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","author":"S Massberg","year":"2010","journal-title":"Nat Med"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2004.11.016","article-title":"Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice","volume":"180","author":"H Ohta","year":"2005","journal-title":"Atherosclerosis"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1161\/ATVBAHA.111.227629","article-title":"Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice","volume":"31","author":"MS Madhur","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1124\/jpet.112.192047","article-title":"The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis","volume":"343","author":"N Schmidt","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1172\/JCI200314915","article-title":"Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice","volume":"111","author":"GK Sukhova","year":"2003","journal-title":"J Clin Invest"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/ATVBAHA.107.144824","article-title":"Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease","volume":"27","author":"M Scatena","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20020945","article-title":"A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo","volume":"197","author":"S Massberg","year":"2003","journal-title":"J Exp Med"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1136\/ard.2004.034777","article-title":"Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s","volume":"64","author":"N Goodson","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1074-7613(00)80411-2","article-title":"A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency","volume":"4","author":"GA Taylor","year":"1996","journal-title":"Immunity"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1042\/CS20090488","article-title":"Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications","volume":"118","author":"E McNeill","year":"2010","journal-title":"Clin Sci (Lond)"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/01.STR.0000226901.34927.10","article-title":"Inflammation and atherosclerosis: novel insights into plaque formation and destabilization","volume":"37","author":"G Stoll","year":"2006","journal-title":"Stroke"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.2741\/1669","article-title":"Transcriptional profiling of early onset diet-induced atherosclerosis in apolipoprotein E-deficient mice","volume":"10","author":"C Castro","year":"2005","journal-title":"Front Biosci"},{"issue":"2\u20134","key":"ref33","first-page":"145","article-title":"Antiatherogenic effect of antioxidant polyphenols from Phellinus baumii in apolipoprotein E-deficient mice","volume":"59","author":"JR Noh","year":"2011","journal-title":"Ann Nutr Metab"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11239-013-1026-5","article-title":"Thrombin generation and atherosclerosis","volume":"37","author":"J Kalz","year":"2014","journal-title":"J Thromb Thrombolysis"},{"issue":"3","key":"ref35","first-page":"1110","article-title":"Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation","volume":"118","author":"C Reinhardt","year":"2008","journal-title":"J Clin Invest"},{"issue":"9","key":"ref36","first-page":"967","article-title":"Cytokines and hemostasis","volume":"85","author":"G Grignani","year":"2000","journal-title":"Haematologica"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0130401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:41:40Z","timestamp":1540309300000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0130401"}},"subtitle":[],"editor":[{"given":"Kathleen","family":"Freson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0130401","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}